Daniel R. Kapusta
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View article: Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female <i>Npr1</i> haplotype mice
Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female <i>Npr1</i> haplotype mice Open
We determined the epigenetic mechanisms regulating mean arterial pressure (MAP) and renal dysfunction in guanylyl cyclase/natriuretic peptide receptor‐A (GC‐A/NPRA) gene‐targeted mice. The Npr1 (encoding NPRA) gene‐targeted mice were treat…
View article: Podocyte cell-specific <i>Npr1</i> is required for blood pressure and renal homeostasis in male and female mice: role of sex-specific differences
Podocyte cell-specific <i>Npr1</i> is required for blood pressure and renal homeostasis in male and female mice: role of sex-specific differences Open
Our results demonstrate that the podocyte-specific deletion of Npr1 showed increased blood pressure (BP) and altered biomarkers of renal functions, with greater magnitudes in animals fed a high-salt diet in a sex-dependent manner. The resu…
View article: Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction
Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction Open
Background The renal sympathetic nervous system modulates systemic blood pressure, cardiac performance, and renal function. Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with pre…
View article: 364 Beneficial Actions of SGLT2 Inhibition and H2S Therapy in Heart Failure with Preserved Ejection Fraction
364 Beneficial Actions of SGLT2 Inhibition and H2S Therapy in Heart Failure with Preserved Ejection Fraction Open
OBJECTIVES/GOALS: SGLT2i therapy is currently a cornerstone in heart failure with preserved ejection fraction (HFpEF) therapy. Similarly, H2S has been shown to be beneficial in preclinical models of heart failure. With this in mind, we sou…
View article: Cardiovascular and renal effects of novel nonpeptide nociceptin opioid peptide receptor agonists
Cardiovascular and renal effects of novel nonpeptide nociceptin opioid peptide receptor agonists Open
Background and Purpose Partial agonists of the nociceptin opioid peptide (NOP) receptor have potential therapeutic use as antihypertensive and water diuretics (aquaretics). To date, peptide NOP receptor ligands have failed to progress in c…
View article: Hypothalamic Paraventricular Nucleus Gαi <sub>2</sub> (Guanine Nucleotide–Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein–Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure
Hypothalamic Paraventricular Nucleus Gαi <sub>2</sub> (Guanine Nucleotide–Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein–Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure Open
We have previously reported that in salt-resistant rat phenotypes brain, Gαi 2 (guanine nucleotide–binding protein alpha inhibiting activity polypeptide 2) proteins are required to maintain blood pressure and sodium balance. However, the i…
View article: Complete atrioventricular block due to timolol eye drops: a case report and literature review
Complete atrioventricular block due to timolol eye drops: a case report and literature review Open
Background Timolol Maleate is a non-selective beta-adrenergic blocker that is commonly used to treat open-angle glaucoma. Despite its topical administration, ophthalmic timolol enters systemic circulation and produces a systemic beta-adren…
View article: Downregulation of Brain Gα12 Attenuates Angiotensin II-Dependent Hypertension
Downregulation of Brain Gα12 Attenuates Angiotensin II-Dependent Hypertension Open
BACKGROUND Angiotensin II (Ang II) activates central Angiotensin II type 1 receptors to increase blood pressure via multiple pathways. However, whether central Gα proteins contribute to Ang II-induced hypertension remains unknown. We hypot…
View article: 3326 Radiofrequency Renal Denervation Prevents Further Progression of Hypertension and Decreases Renal Medullary Fibrosis in One-year-old Spontaneously Hypertensive Rats (SHR)
3326 Radiofrequency Renal Denervation Prevents Further Progression of Hypertension and Decreases Renal Medullary Fibrosis in One-year-old Spontaneously Hypertensive Rats (SHR) Open
OBJECTIVES/SPECIFIC AIMS: We have reported that radiofrequency renal denervation (RF-RDN) in SHR at 20-weeks of age, decreased blood pressure (BP) and fibrosis in kidney cortex and medulla when rats were sacrificed at 6 months. However, wh…
View article: 2267 Radiofrequency renal denervation attenuates kidney fibrosis in spontaneously hypertensive rats
2267 Radiofrequency renal denervation attenuates kidney fibrosis in spontaneously hypertensive rats Open
OBJECTIVES/SPECIFIC AIMS: The goal of this study was to investigate whether RF-RDN attenuates renal fibrosis and inflammation in SHR with established hypertension. METHODS/STUDY POPULATION: Twenty-two-week-old SHR received bilateral RF-RDN…
View article: Sympathoinhibitory Effect of Radiofrequency Renal Denervation in Spontaneously Hypertensive Rats With Established Hypertension
Sympathoinhibitory Effect of Radiofrequency Renal Denervation in Spontaneously Hypertensive Rats With Established Hypertension Open
BACKGROUND Radiofrequency ablation of the renal arteries (RF-ABL) has been shown to decrease blood pressure (BP) in drug-resistant hypertensive patients who receive antihypertensive drug therapy. However, there remain questions regarding h…
View article: Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling
Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling Open
Rationale: Catheter-based renal denervation (RDN) is currently under development for the treatment of resistant hypertension and is thought to reduce blood pressure via interruption of sympathetic pathways that modulate cardiovascular func…