Daniel R. Kuritzkes
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View article: Doravirine Resistance Patterns Identified through Week 192 in the DRIVE-FORWARD and DRIVE-AHEAD Phase 3 Clinical Trials
Doravirine Resistance Patterns Identified through Week 192 in the DRIVE-FORWARD and DRIVE-AHEAD Phase 3 Clinical Trials Open
Background: Doravirine is a non-nucleoside reverse-transcriptase inhibitor (NNRTI) designed to address the limitations of other NNRTIs, particularly resistance due to common RT substitutions including K103N, Y181C, and G190A. Methods: This…
View article: Suspected Immune-Related Adverse Events With an Anti-PD-1 Inhibitor in Otherwise Healthy People With HIV
Suspected Immune-Related Adverse Events With an Anti-PD-1 Inhibitor in Otherwise Healthy People With HIV Open
To the Editors: Reversing T-cell exhaustion using antibodies to immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy. Because T-cell exhaustion, mediated by programmed death-1/programmed death ligand-1 (PD-1/PD-L1), may be…
View article: Establishing shared definitions of virological failure and discontinuation for long-acting injectable cabotegravir and rilpivirine therapy (the CONSENSUS-LAI Study): an international survey and Delphi process
Establishing shared definitions of virological failure and discontinuation for long-acting injectable cabotegravir and rilpivirine therapy (the CONSENSUS-LAI Study): an international survey and Delphi process Open
ViiV Healthcare.
View article: Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV
Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV Open
View article: Determination of RNA structural diversity and its role in HIV-1 RNA splicing
Determination of RNA structural diversity and its role in HIV-1 RNA splicing Open
View article: Author Correction: Determination of RNA structural diversity and its role in HIV-1 RNA splicing
Author Correction: Determination of RNA structural diversity and its role in HIV-1 RNA splicing Open
View article: Clinical Management of Hospitalized Coronavirus Disease 2019 Patients in the United States
Clinical Management of Hospitalized Coronavirus Disease 2019 Patients in the United States Open
BACKGROUND: The objective of this study was to characterize hospitalized coronavirus disease 2019 (COVID-19) patients and describe their real-world treatment patterns and outcomes over time. METHODS: Adult patients hospitalized on May 1, 2…
View article: Remdesivir Treatment in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19): A Comparative Analysis of In-hospital All-cause Mortality in a Large Multicenter Observational Cohort
Remdesivir Treatment in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19): A Comparative Analysis of In-hospital All-cause Mortality in a Large Multicenter Observational Cohort Open
BACKGROUND: Remdesivir (RDV) improved clinical outcomes among hospitalized patients with coronavirus disease 2019 (COVID-19) in randomized trials, but data from clinical practice are limited. METHODS: We examined survival outcomes for US p…
View article: Automated, Deep Learning‐Enabled Immunoassay Microfluidic Cartridge for Viral Pathogen Detection
Automated, Deep Learning‐Enabled Immunoassay Microfluidic Cartridge for Viral Pathogen Detection Open
Enzyme‐linked immunosorbent assays (ELISA) are recognized for their accuracy and versatility in disease diagnostics. However, conventional ELISA protocols rely on laboratory equipment, trained personnel, and established infrastructure, res…
View article: International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak
International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak Open
In May 2022, the most widespread outbreak of sustained transmission of mpox outside of countries historically affected countries in Western and Central Africa occurred. We aimed to examine the personal and clinical experiences of internati…
View article: Safety and Immune Responses Following Anti-PD-1 Monoclonal Antibody Infusions in Healthy Persons With Human Immunodeficiency Virus on Antiretroviral Therapy
Safety and Immune Responses Following Anti-PD-1 Monoclonal Antibody Infusions in Healthy Persons With Human Immunodeficiency Virus on Antiretroviral Therapy Open
Background: T cells in people with human immunodeficiency virus (HIV) demonstrate an exhausted phenotype, and HIV-specific CD4+ T cells expressing programmed cell death 1 (PD-1) are enriched for latent HIV, making antibody to PD…
View article: Increased insulin resistance following switch from efavirenz to cobicistat-boosted elvitegravir
Increased insulin resistance following switch from efavirenz to cobicistat-boosted elvitegravir Open
Background Integrase strand transfer inhibitors (INSTIs) have been associated with excess weight gain in people living with HIV compared to other antiretroviral agents. The mechanisms that underlie these effects are not well defined. Thus,…
View article: The CONSENSUS-LAI Study: Establishing Shared Definitions of Virological Failure and Discontinuation for Long-Acting Injectable Cabotegravir and Rilpivirine Therapy
The CONSENSUS-LAI Study: Establishing Shared Definitions of Virological Failure and Discontinuation for Long-Acting Injectable Cabotegravir and Rilpivirine Therapy Open
View article: Remdesivir for Patients Hospitalized With COVID-19: Evidence of Effectiveness From Cohort Studies in the Omicron Era
Remdesivir for Patients Hospitalized With COVID-19: Evidence of Effectiveness From Cohort Studies in the Omicron Era Open
Remdesivir is the only antiviral approved for treatment of persons hospitalized for coronavirus disease 2019 (COVID-19). This supplement presents new information from real-world cohort studies that report reduced mortality in at-risk popul…
View article: Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV
Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV Open
Key HIV cure strategies involve reversing immune dysfunction and limiting the proliferation of infected T cells. We evaluate the safety of sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in people with HIV (PWH) and study the …
View article: A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?
A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”? Open
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at findin…
View article: International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak
International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak Open
In May 2022, the most widespread outbreak of sustained transmission of mpox outside of countries historically affected countries in Western and Central Africa occurred. We aimed to examine the personal and clinical experiences of internati…
View article: Willingness to trade-off years of life for an HIV cure – an experimental exploration of affective forecasting
Willingness to trade-off years of life for an HIV cure – an experimental exploration of affective forecasting Open
These negative findings suggest that either these biases are difficult to overcome in the settings of HIV curative medication or other factors beyond affective forecasting biases influence willingness to participate in HIV curative studies…
View article: Correction: Caregivers of children with HIV in Botswana prefer monthly IV Broadly Neutralizing Antibodies (bNAbs) to daily oral ART
Correction: Caregivers of children with HIV in Botswana prefer monthly IV Broadly Neutralizing Antibodies (bNAbs) to daily oral ART Open
[This corrects the article DOI: 10.1371/journal.pone.0299942.].
View article: Depression: an individual-level early warning indicator of virologic failure in HIV patients in South Africa
Depression: an individual-level early warning indicator of virologic failure in HIV patients in South Africa Open
OBJECTIVETo identify individual-level early warning indicators of virologic failure in HIV patients receiving antiretroviral therapy (ART) in South Africa.DESIGNA matched case–control study of individuals with and without virologic failure…
View article: High Rates of Missed HIV Testing Among Oral PrEP Users in the United States From 2018–2021: A National Assessment on Compliance With HIV Testing Recommendations of the CDC PrEP Guidelines
High Rates of Missed HIV Testing Among Oral PrEP Users in the United States From 2018–2021: A National Assessment on Compliance With HIV Testing Recommendations of the CDC PrEP Guidelines Open
Background The US Centers for Disease Control and Prevention recommends HIV testing every 3 months in oral PrEP users. We performed a national assessment of HIV testing compliance among oral PrEP users. Methods We analyzed 408 910 PrEP pre…
View article: AMPLON: Amplifying DNA with Multiarm Priming and Looping Optimization of Nucleic Acid
AMPLON: Amplifying DNA with Multiarm Priming and Looping Optimization of Nucleic Acid Open
Nucleic acid amplification, the bedrock of biotechnology and molecular diagnostics, surges in applications—especially isothermal approaches—heightening the demand for advanced and precisely engineered methods. Here, a novel approach for am…
View article: Caregivers of children with HIV in Botswana prefer monthly IV Broadly Neutralizing Antibodies (bNAbs) to daily oral ART
Caregivers of children with HIV in Botswana prefer monthly IV Broadly Neutralizing Antibodies (bNAbs) to daily oral ART Open
Introduction Monthly intravenous infusion of broadly neutralizing monoclonal antibodies may be an attractive alternative to daily oral antiretroviral treatment for children living with HIV. However, acceptability among caregivers remains u…
View article: Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a Open
CD4+ T cells with latent HIV-1 infection persist despite treatment with antiretroviral agents and represent the main barrier to a cure of HIV-1 infection. Pharmacological disruption of viral latency may expose HIV-1-infected cel…
View article: Safety and Immune Responses Following Anti-PD-1 Monoclonal Antibody Infusions in Healthy Persons With Human Immunodeficiency Virus on Antiretroviral Therapy
Safety and Immune Responses Following Anti-PD-1 Monoclonal Antibody Infusions in Healthy Persons With Human Immunodeficiency Virus on Antiretroviral Therapy Open
Background T cells in people with human immunodeficiency virus (HIV) demonstrate an exhausted phenotype, and HIV-specific CD4+ T cells expressing programmed cell death 1 (PD-1) are enriched for latent HIV, making antibody to PD-1 a potenti…
View article: The immunogenicity of an HIV-1 Gag conserved element DNA vaccine in people with HIV and receiving antiretroviral therapy
The immunogenicity of an HIV-1 Gag conserved element DNA vaccine in people with HIV and receiving antiretroviral therapy Open
Objective: The primary objective of the study was to assess the immunogenicity of an HIV-1 Gag conserved element DNA vaccine (p24CE DNA) in people with HIV (PWH) receiving suppressive antiretroviral therapy (ART). Design: AIDS Clinical Tri…
View article: Viral and host mediators of non-suppressible HIV-1 viremia
Viral and host mediators of non-suppressible HIV-1 viremia Open
View article: Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV
Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV Open
In people with HIV (PWH), the post-antiretroviral therapy (ART) window is critical for immune restoration and HIV reservoir stabilization. We employ deep immune profiling and T cell receptor (TCR) sequencing and examine proliferation to as…
View article: Recommendations on data sharing in HIV drug resistance research
Recommendations on data sharing in HIV drug resistance research Open
• Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral dr…
View article: Associations of inflammation‐related proteome with demographic and clinical characteristics of people with HIV in South Africa
Associations of inflammation‐related proteome with demographic and clinical characteristics of people with HIV in South Africa Open
Purpose Elevated levels of inflammation associated with human immunodeficiency virus (HIV) infection are one of the primary causes for the burden of age‐related diseases among people with HIV (PWH). Circulating proteins can be used to inve…