Daniel R. Prows
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View article: Targeting the Complement–Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy
Targeting the Complement–Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy Open
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced disease (COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its C5aR1 receptor, and excess synthesis of glycosphingolipids that lead to in…
View article: Genetic determinants of ammonia-induced acute lung injury in mice
Genetic determinants of ammonia-induced acute lung injury in mice Open
In this study, a genetically diverse panel of 43 mouse strains was exposed to ammonia, and genome-wide association mapping was performed employing a single-nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was used to help re…
View article: Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants
Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants Open
The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired retrograde trafficking within the cilium and multiple organogenesis phenotypes, i…
View article: Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci
Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci Open
Background: Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases wit…
View article: Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci
Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci Open
Background: Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases wit…
View article: Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci
Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Loci Open
Background Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases with…
View article: Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Highly Significant Loci
Heart Disease in a Mutant Mouse Model of Spontaneous Eosinophilic Myocarditis Maps to Three Highly Significant Loci Open
Background Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases with…
View article: Characterization of a mouse model of hypereosinophilia-associated heart disease
Characterization of a mouse model of hypereosinophilia-associated heart disease Open
Hypereosinophilic syndrome is characterized by sustained and marked eosinophilia leading to tissue damage and organ dysfunction. Morbidity and mortality occur primarily due to cardiac and thromboembolic complications. Understanding the cau…
View article: MOESM4 of Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci
MOESM4 of Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci Open
Additional file 4. File containing color-coded SNP genotypes for the haplotype analysis relevant to Fig. 5.
View article: <i>Gpr63</i>is a novel modifier of microcephaly in<i>Ttc21b</i>mouse mutants
<i>Gpr63</i>is a novel modifier of microcephaly in<i>Ttc21b</i>mouse mutants Open
The primary cilium is a critical signaling center for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired retrograde trafficking within the cilium and multiple organogenesis phenotypes, i…
View article: Age and Sex of Mice Markedly Affect Survival Times Associated with Hyperoxic Acute Lung Injury
Age and Sex of Mice Markedly Affect Survival Times Associated with Hyperoxic Acute Lung Injury Open
Mortality associated with acute lung injury (ALI) remains substantial, with recent estimates of 35-45% similar to those obtained decades ago. Although evidence for sex-related differences in ALI mortality remains equivocal, death rates dif…