Explanipedia

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation Open

Jennifer West, Sandeep Satapathy, Daniel R. Whiten, Megan A. Kelly, Nicholas J. Geraghty , et al. · 2021

Neuroserpin preferentially inhibits amyloid formation; a 14-mer region in neuroserpin is implicated in binding to amyloid.

PINK1 signalling in neurodegenerative disease Open

Daniel R. Whiten, Dezerae Cox, Carolyn M. Sue · 2021

PTEN-induced kinase 1 (PINK1) impacts cell health and human pathology through diverse pathways. The strict processing of full-length PINK1 on the outer mitochondrial membrane populates a cytoplasmic pool of cleaved PINK1 (cPINK1) that is c…

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides Open

Juraj Konč, Libby Brown, Daniel R. Whiten, Yukun Zuo, Peter Ravn , et al. · 2021

Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site‐specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for biological applications. Here,…

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides Open

Juraj Konč, Libby Brown, Daniel R. Whiten, Yukun Zuo, Peter Ravn , et al. · 2021

Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site‐specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for biological applications. Here,…

Single cell morphology distinguishes genotype and drug effect in Hereditary Spastic Paraplegia Open

Gautam Wali, Shlomo Berkovsky, Daniel R. Whiten, Alan Mackay‐Sim, Carolyn M. Sue · 2021

Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease Open

Evgeniia Lobanova, Daniel R. Whiten, Francesco Simone Ruggeri, Christopher G. Taylor, Antonina Kouli , et al. · 2021

Aggregation of α-synuclein plays a key role in the development of Parkinson’s disease. Soluble aggregates are present not only within human brain but also the CSF and blood. Characterizing the aggregates present in these biofluids may prov…

Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers Open

Santiago E. Sanchez, Daniel R. Whiten, Georg Meisl, Francesco Simone Ruggeri, Eric Hidari , et al. · 2021

The aggregation of α‐synuclein into small soluble aggregates and then fibrils is important in the development and spreading of aggregates through the brain in Parkinson's disease. Fibrillar aggregates can grow by monomer addition and then …

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons Open

Daniel R. Whiten, Philip W. Brownjohn, Steven Moore, Suman De, Alessio Strano , et al. · 2020

In addition to increased aberrant protein aggregation, inflammation has been proposed as a key element in the pathogenesis and progression of Alzheimer’s disease. How inflammation interacts with other disease pathways and how protein aggre…

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression Open

Suman De, Daniel R. Whiten, Francesco Simone Ruggeri, Craig D. Hughes, Margarida Rodrigues , et al. · 2019

O3‐01‐03: MECHANISM OF TOXICITY INDUCED BY AMYLOID‐BETA AGGREGATES CHANGES DURING THE PROGRESSION OF ALZHEIMER'S DISEASE Open

Suman De, Daniel R. Whiten, Craig D. Hughes, David Klenerman · 2019

Misfolding and aggregation of proteins and peptides is a central pathological and biochemical event shared by many neurodegenerative conditions including Alzheimer's diseases (AD) Soluble aggregated forms of amyloid beta (Aβ) are believed …

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates Open

Tom Scheidt, Urszula Łapińska, Janet R. Kumita, Daniel R. Whiten, David Klenerman , et al. · 2019

Chaperone regulation of individual microscopic events in Aβ42 aggregation reveals the nature of active sites on amyloid fibrils.

ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression Open

Suman De, Daniel R. Whiten, Francesco Simone Ruggeri, Craig D. Hughes, Margarida Rodrigues , et al. · 2019

Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species contribute to disease pro…

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms Open

Suman De, David C. Wirthensohn, Patrick Flagmeier, Craig D. Hughes, Francesco A. Aprile , et al. · 2019

Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures of aggregate populations that are closely linked to neurodegenerative conditions, such as Alzheimer’s disease. Here, we find that soluble aggrega…

Quantifying Co-Oligomer Formation by α-Synuclein Open

Marija Iljina, Alexander J. Dear, Gonzalo Garcia, Suman De, Laura Tosatto , et al. · 2018

Small oligomers of the protein α-synuclein (αS) are highly cytotoxic species associated with Parkinson's disease (PD). In addition, αS can form co-aggregates with its mutational variants and with other proteins such as amyloid-β (Aβ) and t…

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells Open

Daniel R. Whiten, Yukun Zuo, Laura Calò, Minee‐Liane Choi, Suman De , et al. · 2018

The aberrant misfolding and subsequent conversion of monomeric protein into amyloid aggregates characterises many neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. These aggregates are highly heterogeneous in str…

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease Open

Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues , et al. · 2018

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers Open

Daniel R. Whiten, Dezerae Cox, Mathew H. Horrocks, Christopher G. Taylor, Suman De , et al. · 2018

Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates Open

Franziska Kundel, Laura Tosatto, Daniel R. Whiten, David C. Wirthensohn, Mathew H. Horrocks , et al. · 2018

The link between protein aggregation and neurodegenerative disease is well established. However, given the heterogeneity of species formed during the aggregation process, it is difficult to delineate details of the molecular events involve…

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity Open

Dezerae Cox, Daniel R. Whiten, James W. Brown, Mathew H. Horrocks, Rebecca San Gil , et al. · 2018

Proteostasis, or protein homeostasis, encompasses the maintenance of the conformational and functional integrity of the proteome and involves an integrated network of cellular pathways. Molecular chaperones, such as the small heat shock pr…

Inhibiting the Ca2+ Influx Induced by Human CSF Open

Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei‐Hsin Chen , et al. · 2017

Clusterin protects neurons against intracellular proteotoxicity Open

Jenna M. Gregory, Daniel R. Whiten, Rebecca Brown, Teresa P. Barros, Janet R. Kumita , et al. · 2017

It is now widely accepted in the field that the normally secreted chaperone clusterin is redirected to the cytosol during endoplasmic reticulum (ER) stress, although the physiological function(s) of this physical relocation remain unknown.…

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation Open

Rafaa Zeineddine, Daniel R. Whiten, Natalie E. Farrawell, Luke McAlary, Maya A. Hanspal , et al. · 2017

Amyotrophic lateral sclerosis is a devastating neuromuscular degenerative disease characterized by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology including TAR DNA-binding protein of 43 kDa (TDP-4…

Flow Cytometric Measurement of the Cellular Propagation of TDP-43 aggregation Open

Rafaa Zeineddine, Daniel R. Whiten, Natalie E. Farrawell, Luke McAlary, Maya A. Hanspal , et al. · 2017

Amyotrophic lateral sclerosis is a devastating neuromuscular degenerative disease characterised by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology including TAR DNA-binding protein of 43 kDa (TDP-4…

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation Open

Rafaa Zeineddine, Daniel R. Whiten, Natalie E. Farrawell, Luke McAlary, Maya A. Hanspal , et al. · 2017

Amyotrophic lateral sclerosis is a devastating neuromuscular degenerative disease characterized by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology including TAR DNA-binding protein of 43 kDa (TDP-4…

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking Open

Daniel R. Whiten, Rebecca San Gil, Luke McAlary, Justin J. Yerbury, Heath Ecroyd , et al. · 2016

The Role of clusterin in motor neuron disease and the molecular mechanism of its action Open

Daniel R. Whiten · 2016

Amyotrophic lateral sclerosis (ALS) is a currently untreatable disease characterised by the progressive loss of motor neurons. Death typically occurs as a result of respiratory failure within just 3 years of diagnosis. Aberrant protein agg…

Daniel R. Whiten YOU? Author Swipe