Daniel Ramandi
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View article: Upregulation of endocannabinoid signaling in vivo restores striatal synaptic plasticity and motor performance in Huntington's disease mice
Upregulation of endocannabinoid signaling in vivo restores striatal synaptic plasticity and motor performance in Huntington's disease mice Open
Background Synaptic dysfunction underlies early sensorimotor and cognitive deficits in Huntington's disease (HD) and precedes the degeneration of striatal spiny projection neurons and cortical pyramidal neurons. Movement selection and moto…
View article: Mesoscale Imaging of Cortical Sensorimotor Integration in Huntington’s Disease Mice During Reward-Guided Behaviour
Mesoscale Imaging of Cortical Sensorimotor Integration in Huntington’s Disease Mice During Reward-Guided Behaviour Open
Huntington’s disease (HD) is a neurodegenerative disorder that affects numerous brain functions, yet how altered sensory processing contributes to behavioral and learning deficits remains poorly understood. Previous wide-field mesoscale im…
View article: Home cage-based insights into motor learning and strategy adaptation in a Huntington disease mouse model
Home cage-based insights into motor learning and strategy adaptation in a Huntington disease mouse model Open
Huntington disease (HD) is a genetic neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and neuropsychiatric symptoms. Assessing early motor skill deficits in HD mouse models is challenging with t…
View article: Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease
Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease Open
These findings suggest that YAC128 corticostriatal slices show increased D2 sensitivity that is eCB-dependent, and that dopamine and eCB release are altered at an early disease stage. We provide evidence for impaired neuromodulatory signal…
View article: Effect of chronic upregulation of endocannabinoid signaling<i>in vivo</i>with JZL184 on striatal synaptic plasticity and motor learning in YAC128 Huntington disease mice
Effect of chronic upregulation of endocannabinoid signaling<i>in vivo</i>with JZL184 on striatal synaptic plasticity and motor learning in YAC128 Huntington disease mice Open
Synaptic dysfunction underlies early sensorimotor and cognitive deficits, and precedes neurodegeneration in a variety of disorders, including Alzheimer, Parkinson and Huntington disease (HD). A monogenic inherited disorder, HD manifests wi…
View article: Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight
Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight Open
Background Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. Ho…
View article: Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease
Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease Open
Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD). A previous study showed Activin A, whose transcrip…
View article: Age- and region-dependent cortical excitability in the zQ175 Huntington disease mouse model
Age- and region-dependent cortical excitability in the zQ175 Huntington disease mouse model Open
The neurodegenerative disorder, Huntington disease (HD), manifests as disorders of movement, cognition and mood. Although studies report abnormal corticostriatal synaptic function early in HD mouse models, less is known about cortical–cort…
View article: Activin A targets extrasynaptic NMDA receptors to improve neuronal and behavioral deficits in a mouse model of Huntington disease
Activin A targets extrasynaptic NMDA receptors to improve neuronal and behavioral deficits in a mouse model of Huntington disease Open
Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-D-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD). A previous study showed Activin A, whose transcrip…
View article: Chronic multiscale resolution of mouse brain networks using combined mesoscale cortical imaging and subcortical fiber photometry
Chronic multiscale resolution of mouse brain networks using combined mesoscale cortical imaging and subcortical fiber photometry Open
We believe that this method can be utilized to reveal not only global patterns but also cell-specific connectivity that provides insight into corticobasal ganglia circuit organization.
View article: Altered cortical processing of sensory input in Huntington disease mouse models
Altered cortical processing of sensory input in Huntington disease mouse models Open
Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer …
View article: Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy
Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy Open
It is known that hippocampal epileptogenesis is accompanied by hyperexcitability, glutamate-related neuronal dysfunctions and consequently cognitive deficits. However, the neuroprotective role of astrocytic glutamate uptake through the Glu…