Daniel Rayner
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View article: Additive and interactive effects of social, financial and environmental factors on gait speed among community dwelling older adults in Nigeria: A cross-sectional study
Additive and interactive effects of social, financial and environmental factors on gait speed among community dwelling older adults in Nigeria: A cross-sectional study Open
View article: Comparative efficacy of omalizumab, dupilumab, and remibrutinib in chronic spontaneous urticaria: a network meta-analysis of randomized control trials
Comparative efficacy of omalizumab, dupilumab, and remibrutinib in chronic spontaneous urticaria: a network meta-analysis of randomized control trials Open
Omalizumab 300 mg, followed by remibrutinib, exhibited the highest effect sizes across major outcomes for CSU. Newer therapies such as remibrutinib and dupilumab appear generally effective, offering promising tools for CSU patients who may…
View article: The Effect of Mineralocorticoid Receptor Antagonists on Heart Failure with Nonreduced Ejection Fraction: A Systematic Review and Meta-Analysis
The Effect of Mineralocorticoid Receptor Antagonists on Heart Failure with Nonreduced Ejection Fraction: A Systematic Review and Meta-Analysis Open
Among patients with HFnrEF, MRAs reduce HFH. Although MRAs increase the risk of hyperkalemia and worsening renal function, this does not lead to higher rates of drug discontinuation.
View article: Alopecia areata and adverse pregnancy outcomes: A systematic review and meta-analysis
Alopecia areata and adverse pregnancy outcomes: A systematic review and meta-analysis Open
View article: Bi-directional association between female pattern hair loss and polycystic ovary syndrome: A systematic review and meta-analysis
Bi-directional association between female pattern hair loss and polycystic ovary syndrome: A systematic review and meta-analysis Open
View article: Patient and Healthcare Professional Perspectives Towards the Impact of Hidradenitis Suppurativa on Pregnancy and Perinatal Care: A Systematic Review
Patient and Healthcare Professional Perspectives Towards the Impact of Hidradenitis Suppurativa on Pregnancy and Perinatal Care: A Systematic Review Open
View article: Cardiovascular, kidney related, and weight loss effects of therapeutics for type 2 diabetes: a living clinical practice guideline
Cardiovascular, kidney related, and weight loss effects of therapeutics for type 2 diabetes: a living clinical practice guideline Open
Clinical question What are the benefits and harms of medications for adults with type 2 diabetes at varied risks of cardiovascular and kidney related complications? Context Emerging clinical trials of novel medications have demonstrated be…
View article: Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies
Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies Open
Objective To summarise available evidence regarding the performance metrics of validated prognostic models on cardiovascular and kidney outcomes in adults with type 2 diabetes mellitus. Design Living systematic review and meta-analysis of …
View article: Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis
Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis Open
Among individuals with chronic urticaria refractory to antihistamines, standard-dose omalizumab and remibrutinib are among the most effective drugs across multiple patient-important outcomes with a favorable safety profile across the studi…
View article: Prevalence of Mental Health Symptoms in Patients With Atopic Dermatitis: A Systematic Review and Meta‐Analysis
Prevalence of Mental Health Symptoms in Patients With Atopic Dermatitis: A Systematic Review and Meta‐Analysis Open
View article: Triple therapy vs dual inhaler therapy for moderate-to-severe asthma
Triple therapy vs dual inhaler therapy for moderate-to-severe asthma Open
View article: Application and Implementation Gaps in the Conical Model for Older Adults’ Mobility: A Scoping Review
Application and Implementation Gaps in the Conical Model for Older Adults’ Mobility: A Scoping Review Open
Background: The 2010 Conical Model of Theoretical Framework for Mobility in Older Adults examines how various factors impact elderly mobility. A decade later, describing the model’s application in research, clinical practice, and policy is…
View article: Predictors of drug survival of biologics in hidradenitis suppurativa: A systematic review and meta-analysis
Predictors of drug survival of biologics in hidradenitis suppurativa: A systematic review and meta-analysis Open
View article: COMPARATIVE EFFECTS OF BIOLOGICS AND SMALL MOLECULE INHIBITORS ON CUTANEOUS DISEASE ACTIVITY IN SYSTEMIC AND CUTANEOUS LUPUS ERYTHEMATOSUS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
COMPARATIVE EFFECTS OF BIOLOGICS AND SMALL MOLECULE INHIBITORS ON CUTANEOUS DISEASE ACTIVITY IN SYSTEMIC AND CUTANEOUS LUPUS ERYTHEMATOSUS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS Open
O055 / #488 Topic: AS07 - Cutaneous Lupus ABSTRACT CONCURRENT SESSION 09: SLE THERAPY – REVISITING OLD DRUGS AND UNLOCKING HIDDEN POTENTIAL OF NEW MEDICATIONS 24-05-2025 10:40 AM - 11:40 AM Background/Purpose Cutaneous lupus erythematosus …
View article: Predictive value of self-prioritized mobility factors on gait speed and life space in older nigerians: A cross-sectional study
Predictive value of self-prioritized mobility factors on gait speed and life space in older nigerians: A cross-sectional study Open
Background and Objectives: Eighty-two cognitive, environmental, financial, personal, physical, psychological, and social factors significantly influence mobility decline following hospital discharge. However, assessing all these factors du…
View article: Sedation Versus General Anesthesia for Ablation of Ventricular Arrhythmias: A Systematic Review and Meta-Analysis
Sedation Versus General Anesthesia for Ablation of Ventricular Arrhythmias: A Systematic Review and Meta-Analysis Open
Ventricular arrhythmias (VA), including ventricular tachycardia and fibrillation, are critical cardiac conditions that are often managed by catheter ablation among those unresponsive to pharmacologic therapy. The choice of anesthesia and s…
View article: Prevalence of Mental Health Symptoms in Chronic Urticaria: A Systematic Review and Meta‐Analysis
Prevalence of Mental Health Symptoms in Chronic Urticaria: A Systematic Review and Meta‐Analysis Open
View article: Inhaled Reliever Therapies for Asthma
Inhaled Reliever Therapies for Asthma Open
Importance The optimal inhaled reliever therapy for asthma remains unclear. Objective To compare short-acting β agonists (SABA) alone with SABA combined with inhaled corticosteroids (ICS) and with the fast-onset, long-acting β agonist form…
View article: Patient-Reported Outcome Measures in Cancer Care
Patient-Reported Outcome Measures in Cancer Care Open
Importance Patient-reported outcome measures (PROMs) come directly from the patient, without clinician interpretation, to provide a patient-centered perspective. Objective To understand the association of PROM integration into cancer care …
View article: Topical corticosteroids for hives and itch (urticaria): Systematic review and Bayesian meta-analysis of randomized trials
Topical corticosteroids for hives and itch (urticaria): Systematic review and Bayesian meta-analysis of randomized trials Open
Compared with placebo, topical corticosteroids may result in a reduction of wheal size and little to no difference in overall adverse events. Topical corticosteroids may reduce itch severity, but the evidence is very uncertain. Future larg…
View article: Barriers and facilitators to perioperative smoking cessation: A scoping review
Barriers and facilitators to perioperative smoking cessation: A scoping review Open
Objective Smoking cessation interventions are underutilized in the surgical setting. We aimed to systematically identify the barriers and facilitators to smoking cessation in the surgical setting. Methods Following the Joanna Briggs Instit…
View article: The role of mitochondrial genes in ischemia-reperfusion injury: A systematic review of experimental studies
The role of mitochondrial genes in ischemia-reperfusion injury: A systematic review of experimental studies Open
Mitochondrial dysfunction contributes to pathological conditions like ischemia-reperfusion (IR) injury. To address the lack of effective therapeutic interventions for IR injury and potential knowledge gaps in the current literature, we sys…
View article: A brief step-by-step guide on conducting a systematic review and meta-analysis of prognostic model studies
A brief step-by-step guide on conducting a systematic review and meta-analysis of prognostic model studies Open
Prognostic models provide an avenue to predict the risk of individual patients and support shared-decision making. Many prognostic models are published annually, and systematic reviews provide an avenue to collate the existing evidence beh…
View article: Use of induction therapy post‐heart transplantation: Clinical practice recommendations based on systematic review and network meta‐analysis of evidence
Use of induction therapy post‐heart transplantation: Clinical practice recommendations based on systematic review and network meta‐analysis of evidence Open
Background The use of induction therapy (IT) agents in the early post‐heart transplant period remains controversial. The following recommendations aim to provide guidance on the use of IT agents, including Basiliximab and Thymoglobulin, as…
View article: Comparison of Self-Reported and Capacity-Based Measures of Mobility in Community-Dwelling Older Adults in Nigeria: The Mediating Role of Age, Cognitive Status, and Chronic Conditions
Comparison of Self-Reported and Capacity-Based Measures of Mobility in Community-Dwelling Older Adults in Nigeria: The Mediating Role of Age, Cognitive Status, and Chronic Conditions Open
Background and Objectives Although the association between self-reported and capacity-based mobility outcomes is prominently researched, the pathways through which self-reported measures affect capacity-based measures remains poorly unders…
View article: Trial Characteristics of Randomized Controlled Trials Evaluating Bronchial Thermoplasty in Moderate and Severe Asthma: An AAAAI/ACAAI JTFPP Systematic Review
Trial Characteristics of Randomized Controlled Trials Evaluating Bronchial Thermoplasty in Moderate and Severe Asthma: An AAAAI/ACAAI JTFPP Systematic Review Open
View article: Efficacy and safety of leukotriene receptor antagonists as an add-on therapy for the management of antihistamine refractory chronic urticaria: a systematic review and meta-analysis
Efficacy and safety of leukotriene receptor antagonists as an add-on therapy for the management of antihistamine refractory chronic urticaria: a systematic review and meta-analysis Open
View article: Systemic Treatments for Atopic Dermatitis: Systematic Review and Network Meta-Analysis of Randomized Trials
Systemic Treatments for Atopic Dermatitis: Systematic Review and Network Meta-Analysis of Randomized Trials Open
View article: An AAAAI/ACAAI Joint Task Force on Practice Parameters Updated Systematic Review of Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma
An AAAAI/ACAAI Joint Task Force on Practice Parameters Updated Systematic Review of Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma Open
View article: Longitudinal Studies of Aging in Sub-Saharan Africa: Review, Limitations, and Recommendations in Preparation of Projected Aging Population
Longitudinal Studies of Aging in Sub-Saharan Africa: Review, Limitations, and Recommendations in Preparation of Projected Aging Population Open
Background and Objectives The United Nations has projected a 218% increase in older people in Sub-Saharan Africa (SSA) between 2019 and 2050, underscoring the need to explore changes that would occur over this time. Longitudinal studies ar…