Daniel Roxbury
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View article: Enhancing Optical Properties and Stability of DNA-Functionalized Carbon Nanotubes with Cryoprotectant-Mediated Lyophilization
Enhancing Optical Properties and Stability of DNA-Functionalized Carbon Nanotubes with Cryoprotectant-Mediated Lyophilization Open
The long-term optical performance and stability of single-walled carbon nanotubes (SWCNTs) functionalized with single-stranded DNA are critical for their application in near-infrared (NIR) fluorescence biological sensing and imaging. Howev…
View article: Machine Learning Assisted Spectral Fingerprinting for Immune Cell Phenotyping
Machine Learning Assisted Spectral Fingerprinting for Immune Cell Phenotyping Open
Spectral fingerprinting has emerged as a powerful tool, adept at identifying chemical compounds and deciphering complex interactions within cells and engineered nanomaterials. Using near-infrared (NIR) fluorescence spectral fingerprinting …
View article: Enhancing Intracellular Optical Performance and Stability of Engineered Nanomaterials via Aqueous Two-Phase Purification
Enhancing Intracellular Optical Performance and Stability of Engineered Nanomaterials via Aqueous Two-Phase Purification Open
Supramolecular hybrids of DNA and single-walled carbon nanotubes (SWCNTs) have been introduced in numerous biosensing applications due to their unique optical properties. Recent aqueous two-phase (ATP) purification methods for SWCNTs have …
View article: Aggregation Reduces Subcellular Localization and Cytotoxicity of Single-Walled Carbon Nanotubes
Aggregation Reduces Subcellular Localization and Cytotoxicity of Single-Walled Carbon Nanotubes Open
The non-covalent biomolecular functionalization of fluorescent single-walled carbon nanotubes (SWCNTs) has resulted in numerous in vitro and in vivo sensing and imaging applications due to many desirable optical properties. In these applic…
View article: Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles
Hyperspectral Counting of Multiplexed Nanoparticle Emitters in Single Cells and Organelles Open
Nanomaterials are the subject of a range of biomedical, commercial, and environmental investigations involving measurements in living cells and tissues. Accurate quantification of nanomaterials, at the tissue, cell, and organelle levels, i…
View article: Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes
Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes Open
Applications of single-walled carbon nanotubes (SWCNTs) in bioimaging and biosensing have been limited by difficulties with isolating single-chirality nanotube preparations with desired functionalities. Unique optical properties, such as m…
View article: A Spin-Coated Hydrogel Platform Enables Accurate Investigation of Immobilized Individual Single-Walled Carbon Nanotubes
A Spin-Coated Hydrogel Platform Enables Accurate Investigation of Immobilized Individual Single-Walled Carbon Nanotubes Open
Single-walled carbon nanotubes (SWCNTs) have been used in a variety of sensing and imaging applications over the past few years due to their unique optical properties. In the solution phase, SWCNTs are employed as near-infrared (NIR) fluor…
View article: Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells
Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells Open
Intracellular vesicle trafficking involves a complex series of biological pathways used to sort, recycle, and degrade extracellular components, including engineered nanomaterials (ENMs) which gain cellular entry via active endocytic proces…
View article: A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress
A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress Open
In an effort to facilitate personalized medical approaches, the continuous and noninvasive monitoring of biochemical information using wearable technologies can enable a detailed understanding of an individual's physiology. Reactive oxygen…
View article: Carbon Nanotube–Liposome Complexes in Hydrogels for Controlled Drug Delivery via Near-Infrared Laser Stimulation
Carbon Nanotube–Liposome Complexes in Hydrogels for Controlled Drug Delivery via Near-Infrared Laser Stimulation Open
Externally controllable drug delivery systems are crucial for a variety of biological applications where the dosage and timing of drug delivery need to be adjusted based on disease diagnosis and progression. Here, we have developed an exte…
View article: Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells
Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells Open
Intracellular vesicle trafficking involves a complex series of biological pathways used to sort, recycle, and degrade extracellular components, including engineered nanomaterials which gain cellular entry via active endocytic processes. A …
View article: A Magnetically Responsive Hydrogel System for Controlling the Timing of Bone Progenitor Recruitment and Differentiation Factor Deliveries
A Magnetically Responsive Hydrogel System for Controlling the Timing of Bone Progenitor Recruitment and Differentiation Factor Deliveries Open
The sequence and timing of growth factor delivery plays a crucial role in bone regeneration. While a variety of biomaterial scaffolds have been developed to provide multiple growth factor deliveries, there still exists a strong need for on…
View article: Optical Voltammetry of Polymer-Encapsulated Single-Walled Carbon Nanotubes
Optical Voltammetry of Polymer-Encapsulated Single-Walled Carbon Nanotubes Open
The semiconducting single-walled carbon nanotube (SWCNT), noncovalently wrapped by a polymeric monolayer, is a nanoscale semiconductor-electrolyte interface under investigation for sensing, photonics, and photovoltaic applications. SWCNT c…
View article: Biomolecular Functionalization of a Nanomaterial To Control Stability and Retention within Live Cells
Biomolecular Functionalization of a Nanomaterial To Control Stability and Retention within Live Cells Open
Noncovalent hybrids of single-stranded DNA and single-walled carbon nanotubes (SWCNTs) have demonstrated applications in biomedical imaging and sensing due to their enhanced biocompatibility and photostable, environmentally responsive near…
View article: Oligonucleotide Length Determines Intracellular Stability of DNA-Wrapped Carbon Nanotubes
Oligonucleotide Length Determines Intracellular Stability of DNA-Wrapped Carbon Nanotubes Open
Non-covalent hybrids of single-stranded DNA and single-walled carbon nanotubes (SWCNTs) have demonstrated applications in biomedical imaging and sensing due to their enhanced biocompatibility and photostable, environmentally-responsive nea…
View article: DNA Sequence Mediates Apparent Length Distribution in Single-Walled Carbon Nanotubes
DNA Sequence Mediates Apparent Length Distribution in Single-Walled Carbon Nanotubes Open
Single-walled carbon nanotubes (SWCNTs) functionalized with short single-stranded DNA have been extensively studied within the last decade for biomedical applications due to the high dispersion efficiency and intrinsic biocompatibility of …
View article: An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo
An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo Open
A nanoreporter noninvasively detects endolysosomal lipids, revealing that short-term changes in diet have enduring effects on hepatic macrophages.
View article: A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux Open
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipi…
View article: DNA–Carbon Nanotube Complexation Affinity and Photoluminescence Modulation Are Independent
DNA–Carbon Nanotube Complexation Affinity and Photoluminescence Modulation Are Independent Open
Short single-stranded DNA (ssDNA) has emerged as the natural polymer of choice for noncovalently functionalizing photoluminescent single-walled carbon nanotubes. In addition, specific empirically identified DNA sequences can be used to sep…
View article: A carbon nanotube optical reporter maps endolysosomal lipid flux
A carbon nanotube optical reporter maps endolysosomal lipid flux Open
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipi…
View article: A Carbon Nanotube Optical Sensor Reports Nuclear Entry <i>via</i> a Noncanonical Pathway
A Carbon Nanotube Optical Sensor Reports Nuclear Entry <i>via</i> a Noncanonical Pathway Open
Single-walled carbon nanotubes are of interest in biomedicine for imaging and molecular sensing applications and as shuttles for various cargos such as chemotherapeutic drugs, peptides, proteins, and oligonucleotides. Carbon nanotube surfa…
View article: Single Nanotube Spectral Imaging To Determine Molar Concentrations of Isolated Carbon Nanotube Species
Single Nanotube Spectral Imaging To Determine Molar Concentrations of Isolated Carbon Nanotube Species Open
Electronic and biological applications of carbon nanotubes can be highly dependent on the species (chirality) of nanotube, purity, and concentration. Existing bulk methods, such as absorbance spectroscopy, can quantify sp2 carbon based on …
View article: Review—Progress toward Applications of Carbon Nanotube Photoluminescence
Review—Progress toward Applications of Carbon Nanotube Photoluminescence Open
In the fifteen years following the discovery of single-walled carbon nanotube (SWCNT) photoluminescence, investigators have made significant progress in their understanding of the phenomenon and towards the development of applications. The…