Daniel S. Farrar
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View article: Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus
Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus Open
Importance A resurgence of respiratory syncytial virus (RSV)–associated acute respiratory tract infection (ARI) was observed in 2022 and 2023 after the COVID-19 pandemic. Changes in the demographic characteristics, disease severity, and ou…
View article: Performance of the World Health Organization (WHO) severe acute respiratory infection (SARI) case definitions in hospitalized children and youth: cross-sectional study
Performance of the World Health Organization (WHO) severe acute respiratory infection (SARI) case definitions in hospitalized children and youth: cross-sectional study Open
View article: Estimation of unconfirmed COVID-19 cases from a cross-sectional survey of >10 000 households and a symptom-based machine learning model in Gilgit-Baltistan, Pakistan
Estimation of unconfirmed COVID-19 cases from a cross-sectional survey of >10 000 households and a symptom-based machine learning model in Gilgit-Baltistan, Pakistan Open
Introduction Robust estimates of COVID-19 prevalence in settings with limited capacity for SARS-CoV-2 molecular and serologic testing are scarce. We aimed to describe the epidemiology of confirmed and probable COVID-19 in Gilgit-Baltistan,…
View article: The Effect of Age and Comorbidities: Children vs. Adults in Their Response to SARS-CoV-2 Infection
The Effect of Age and Comorbidities: Children vs. Adults in Their Response to SARS-CoV-2 Infection Open
While children have experienced less severe coronavirus disease (COVID-19) after SARS-CoV-2 infection than adults, the cause of this remains unclear. The objective of this study was to describe the humoral immune response to COVID-19 in ch…
View article: Association of maternal, obstetric, fetal, and neonatal mortality outcomes with Lady Health Worker coverage from a cross-sectional survey of >10,000 households in Gilgit-Baltistan, Pakistan
Association of maternal, obstetric, fetal, and neonatal mortality outcomes with Lady Health Worker coverage from a cross-sectional survey of >10,000 households in Gilgit-Baltistan, Pakistan Open
Pakistan has among the highest rates of maternal, perinatal, and neonatal mortality globally. Many of these deaths are potentially preventable with low-cost, scalable interventions delivered through community-based health worker programs t…
View article: An integrated newborn care kit (iNCK) to save newborn lives and improve health outcomes in Gilgit Baltistan (GB), Pakistan: study protocol for a cluster randomized controlled trial
An integrated newborn care kit (iNCK) to save newborn lives and improve health outcomes in Gilgit Baltistan (GB), Pakistan: study protocol for a cluster randomized controlled trial Open
View article: 1380. Machine Learning-based Estimation of Unconfirmed COVID-19 Cases from a 10,000-Household Survey in Gilgit-Baltistan, Pakistan
1380. Machine Learning-based Estimation of Unconfirmed COVID-19 Cases from a 10,000-Household Survey in Gilgit-Baltistan, Pakistan Open
Background Robust estimates of COVID-19 prevalence during the pandemic are scarce, particularly in settings with limited SARS-CoV-2 testing. Gilgit-Baltistan (GB) is a remote region of Pakistan where healthcare access is limited by underde…
View article: Higher SARS-CoV-2 antibody response following infection in children compared to adult members of the same family
Higher SARS-CoV-2 antibody response following infection in children compared to adult members of the same family Open
Background While children have had less severe clinical disease after SARS-CoV-2 infection (COVID-19), the cause of this remains unclear. The objective of this study was to describe the humoral immune response to COVID-19 in children vs. a…
View article: 24 Characteristics and Outcomes of Hospitalized Children by SARS-Cov-2 Lineage: An IMPACT Surveillance Network Analysis
24 Characteristics and Outcomes of Hospitalized Children by SARS-Cov-2 Lineage: An IMPACT Surveillance Network Analysis Open
Introduction/Background Changes in relative virulence of SARS-CoV-2 lineages among children remain poorly understood, yet are important considerations for vaccination and health resource management. Further evidence is needed to assess the…
View article: 49 Systematic Review and Meta-analysis of SARS-CoV-2 Vaccine Acceptance in Parents of Children Aged 5-11
49 Systematic Review and Meta-analysis of SARS-CoV-2 Vaccine Acceptance in Parents of Children Aged 5-11 Open
Background Despite the well-studied benefits and safety of SARS-CoV-2 vaccines, many caregivers of children aged 5 to 11 years old remain hesitant to have their child vaccinated. Reasons for vaccine non-acceptance and barriers specific to …
View article: 93 SARS-CoV-2 Vaccine Acceptance and Uptake among Caregivers of Children 5-11 Years of Age: A Cross-sectional Survey
93 SARS-CoV-2 Vaccine Acceptance and Uptake among Caregivers of Children 5-11 Years of Age: A Cross-sectional Survey Open
Background Although vaccination of children aged 5-11 years against SARS-CoV-2 is recommended in Canada, nearly half of Ontarian children this age remain unvaccinated. Objectives This study aimed to assess caregivers’ vaccine acceptance an…
View article: An integrated newborn care kit (iNCK) to save newborn lives and improve health outcomes in Gilgit Baltistan (GB), Pakistan: study protocol for a cluster randomized controlled trial
An integrated newborn care kit (iNCK) to save newborn lives and improve health outcomes in Gilgit Baltistan (GB), Pakistan: study protocol for a cluster randomized controlled trial Open
Background Ongoing high neonatal mortality rates (NMRs) represent a global challenge. In 2021, of the 5 million deaths reported worldwide for children under five years of age, 47% were newborns. Pakistan has one of the five highest nationa…
View article: Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage
Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage Open
View article: SARS-CoV-2 vaccine acceptance among caregivers of children younger than five years of age: A cross-sectional survey in Toronto
SARS-CoV-2 vaccine acceptance among caregivers of children younger than five years of age: A cross-sectional survey in Toronto Open
These findings highlight the importance of interventions to increase vaccine confidence among caregivers of children aged younger than five years old.
View article: Acceptation du vaccin contre le SRAS-CoV-2 chez les parents et tuteurs d'enfants de moins de cinq ans : sondage transversal à Toronto
Acceptation du vaccin contre le SRAS-CoV-2 chez les parents et tuteurs d'enfants de moins de cinq ans : sondage transversal à Toronto Open
Contexte : Malgré l'autorisation du vaccin contre le coronavirus 2 du syndrome respiratoire aigu sévère (SRAS-CoV-2) pour les enfants de six mois à cinq ans au Canada, l'acceptation du vaccin pour ce groupe d'âge demeure faible comparative…
View article: Comparaison de la gravité de la maladie et de l'utilisation des ressources entre les enfants hospitalisés pour la COVID-19 et les enfants hospitalisés pour un syndrome inflammatoire multisystémique chez les enfants (SIME) au Canada
Comparaison de la gravité de la maladie et de l'utilisation des ressources entre les enfants hospitalisés pour la COVID-19 et les enfants hospitalisés pour un syndrome inflammatoire multisystémique chez les enfants (SIME) au Canada Open
Contexte : Une comparaison de la gravité de la maladie et de l'utilisation des ressources entre les hospitalisations pédiatriques pour la maladie à coronavirus aiguë de 2019 (COVID-19) et le syndrome inflammatoire multisystémique chez les …
View article: Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada
Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada Open
While there were more hospitalizations and deaths from acute paediatric COVID-19, MIS-C cases were more severe, requiring more intensive care and vasopressor support. Our findings suggest that both acute COVID-19 and MIS-C should be consid…
View article: Pediatricians’ perceptions, practices, and barriers regarding COVID-19 vaccine for children: A cross-sectional survey in Ontario, Canada
Pediatricians’ perceptions, practices, and barriers regarding COVID-19 vaccine for children: A cross-sectional survey in Ontario, Canada Open
View article: 50 Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021
50 Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021 Open
Background Children living with chronic comorbid conditions are at increased risk for severe COVID-19 disease, though there is limited evidence regarding the risks associated with specific conditions and which children may benefit from tar…
View article: 58 Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada
58 Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada Open
Background There are limited data on outcomes of SARS-CoV-2 infection among infants (<1 year of age). In the absence of approved vaccines for infants, understanding characteristics associated with hospitalization and severe disease from…
View article: Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada
Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada Open
Background There are limited data on outcomes of SARS-CoV-2 infection among infants (<1 year of age). In the absence of approved vaccines for infants, understanding characteristics associated with hospitalization and severe disease from CO…
View article: Demographic and Outcome Characteristics of Children Hospitalized with Acute COVID-19 versus Multisystem Inflammatory Syndrome in Children in Canada
Demographic and Outcome Characteristics of Children Hospitalized with Acute COVID-19 versus Multisystem Inflammatory Syndrome in Children in Canada Open
Direct comparisons of pediatric hospitalizations for acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning. While there were more hospitalizations and deaths from acute COVID-19 amongst …
View article: Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021
Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021 Open
View article: Epidemiology and role of SARS-CoV-2 Linkage in Paediatric Inflammatory Multisystem Syndrome (PIMS): A Canadian Paediatric Surveillance Program National Prospective Study
Epidemiology and role of SARS-CoV-2 Linkage in Paediatric Inflammatory Multisystem Syndrome (PIMS): A Canadian Paediatric Surveillance Program National Prospective Study Open
Background Paediatric inflammatory multisystem syndrome (PIMS) is a rare but serious condition temporally associated with SARS-CoV-2 infection. Using the Canadian Paediatric Surveillance Program (CPSP), a national surveillance system, we a…
View article: Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021
Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021 Open
Background Children living with chronic comorbid conditions are at increased risk for severe COVID-19, though there is limited evidence regarding the risks associated with specific conditions and which children may benefit from targeted CO…
View article: Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada
Clinical manifestations and disease severity of SARS-CoV-2 infection among infants in Canada Open
Importance There are limited data on outcomes of SARS-CoV-2 infection among infants (<1 year of age). In the absence of approved vaccines for infants, understanding characteristics associated with hospitalization and severe disease from CO…
View article: Caractéristiques des hospitalisations au Canada d’enfants ayant contracté une infection aiguë par le SRAS-CoV-2 en 2020
Caractéristiques des hospitalisations au Canada d’enfants ayant contracté une infection aiguë par le SRAS-CoV-2 en 2020 Open
CONTEXTE: Les facteurs de risque de complications graves de l’infection par le SRAS-CoV-2 n’ont pas été bien établis chez les enfants. Nous avons voulu décrire les hospitalisations pédiatriques associées au SRAS-CoV-2 au Canada et identifi…
View article: 483. Disease Severity and Clinical Manifestations of SARS-CoV-2 Infection Among Infants Over the First Year of the Pandemic in Canada
483. Disease Severity and Clinical Manifestations of SARS-CoV-2 Infection Among Infants Over the First Year of the Pandemic in Canada Open
Background There is limited data on outcomes of SARS-CoV-2 infection among infants (< 1 year of age). In the absence of any approved vaccines for infants, understanding the risk factors for hospitalization and severe disease from COVID-…
View article: Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020
Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020 Open
Among children who were admitted to hospital with SARS-CoV-2 infection in Canada during the early COVID-19 pandemic period, incidental SARS-CoV-2 infection was common. In children admitted with acute COVID-19, obesity and neurologic and re…
View article: The impact of the COVID-19 pandemic on influenza, respiratory syncytial virus, and other seasonal respiratory virus circulation in Canada: A population-based study
The impact of the COVID-19 pandemic on influenza, respiratory syncytial virus, and other seasonal respiratory virus circulation in Canada: A population-based study Open