Daniel Saar
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View article: Role of charges in a dynamic disordered complex between an IDP and a folded domain
Role of charges in a dynamic disordered complex between an IDP and a folded domain Open
Protein complexes involving intrinsically disordered proteins (IDPs) cover a continuum from IDPs that fully fold upon binding to IDPs that remain fully disordered in the complex. Here we demonstrate a case of charge-driven interactions of …
View article: Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity
Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity Open
Peroxisome proliferator-activated receptor γ (PPARγ) is a master transcriptional regulator of systemic insulin sensitivity and energy balance. The anti-diabetic drug thiazolidinediones (TZDs) are potent synthetic PPARγ ligands with undesir…
View article: The Myotubularin Related Proteins and the Untapped Interaction Potential of Their Disordered C‐Terminal Regions
The Myotubularin Related Proteins and the Untapped Interaction Potential of Their Disordered C‐Terminal Regions Open
Intrinsically disordered regions (IDRs) of proteins remain understudied with enigmatic sequence features relevant to their functions. Members of the myotubularin‐related protein (MTMR) family contain uncharacterized IDRs. After decades of …
View article: PPARγ antagonists induce aromatase transcription in adipose tissue cultures
PPARγ antagonists induce aromatase transcription in adipose tissue cultures Open
Aromatase is the rate-limiting enzyme in the biosynthesis of estrogens and a key risk factor for hormone receptor-positive breast cancer. In postmenopausal women, estrogens synthesized in adipose tissue promotes the growth of estrogen rece…
View article: The GET insertase exhibits conformational plasticity and induces membrane thinning - The Molecular Dynamics Dataset
The GET insertase exhibits conformational plasticity and induces membrane thinning - The Molecular Dynamics Dataset Open
The molecular dynamics simulation systems. List of files: SimulationSystems.pdf: List of all simulation systems reported and their compositions ProteinComplex.pdb: The initial model for the hsGet2ΔN-Get1/Get3 complex used in simulations wa…
View article: The GET insertase exhibits conformational plasticity and induces membrane thinning - The Molecular Dynamics Dataset
The GET insertase exhibits conformational plasticity and induces membrane thinning - The Molecular Dynamics Dataset Open
The molecular dynamics simulation systems. List of files: SimulationSystems.pdf: List of all simulation systems reported and their compositions ProteinComplex.pdb: The initial model for the hsGet2ΔN-Get1/Get3 complex used in simulations wa…
View article: Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching
Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching Open
Integrating research and teaching in a meaningful manner is a challenge. With the growing number of students in universities and the rapid advances and innovations across many fields and technologies, the one-on-one mentor relationship see…
View article: Structure, dynamics, and stability of the globular domain of human linker histone <scp>H1</scp>.0 and the role of positive charges
Structure, dynamics, and stability of the globular domain of human linker histone <span>H1</span>.0 and the role of positive charges Open
Linker histone H1 (H1) is an abundant chromatin‐binding protein that acts as an epigenetic regulator binding to nucleosomes and altering chromatin structures and dynamics. Nonetheless, the mechanistic details of its function remain poorly …
View article: Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma
Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma Open
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a transcription factor drugable by agonists approved for treatment of type 2 diabetes, but also inhibits carcinogenesis and cell proliferation in vivo. Activating mutations in the…