Daniel Schramek
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View article: Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways Open
SUMMARY Pathogens deploy effector proteins to exploit host cell biology, and most pathogen open reading frames (ORFs) are rapidly evolving and lack functional annotation. We developed the eORFeome, a scalable functional genomics platform e…
View article: OS09.5.A RECURRENT COPY NUMBER ALTERATIONS DRIVE IDH-MUTANT ASTROCYTOMA DEVELOPMENT AND PROGRESSION
OS09.5.A RECURRENT COPY NUMBER ALTERATIONS DRIVE IDH-MUTANT ASTROCYTOMA DEVELOPMENT AND PROGRESSION Open
BACKGROUND IDH-mutant gliomas are diffusely infiltrating, slow-growing brain tumors that inevitably undergo malignant progression to grade IV astrocytoma - a highly aggressive and uniformly fatal disease with dismal prognosis. Despite exte…
View article: De novo design of potent inhibitors of clostridial family toxins
De novo design of potent inhibitors of clostridial family toxins Open
Clostridioides difficile remains a leading cause of hospital-acquired infections, with its primary virulence factor, toxin B (TcdB), responsible for severe colitis and recurrent disease. The closely related toxin, TcsL, from Paeniclostridi…
View article: Temporal control of sgRNA library activation unlocks large-scale <i>in vivo</i> CRISPR screens
Temporal control of sgRNA library activation unlocks large-scale <i>in vivo</i> CRISPR screens Open
Functional genomics screens have illuminated genetic dependencies in cancer, but conventional in vitro approaches fail to capture vulnerabilities shaped by the tumor microenvironment. Here, we implement CRISPR-StAR (Stochastic Activation b…
View article: Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response
Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response Open
Proton-mediated activation of acid-sensing ion channel 1a (ASIC1a) leads to influx of sodium and, to a lesser extent, calcium, followed by rapid and complete desensitization. However, various ASIC1a-expressing cell types display atypical p…
View article: Table S5 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S5 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
qBF scores GSC screens vs Nonmalignant control screens
View article: Table S6 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S6 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Normalized Bayes Factor Scores for GSC and GBM cell line screens
View article: Table S1 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S1 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Sequence of gRNAs used in this study
View article: Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
DESEQ2 analysis of control vs Ptk2 knockout mouse GBM tumor samples
View article: Table S2 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S2 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Sequence of qPCR primers used in this study.
View article: Table S3 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S3 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
GBM5K Library Composition. Gene list and Source for inclusion in library (see "Key" tab)
View article: Table S4 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S4 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
normalized Bayes Factor scores, essentiality calls and subtype scores from GBM5K and TKOv3 screens
View article: Table S5 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S5 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
qBF scores GSC screens vs Nonmalignant control screens
View article: Table S4 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S4 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
normalized Bayes Factor scores, essentiality calls and subtype scores from GBM5K and TKOv3 screens
View article: Table S1 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S1 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Sequence of gRNAs used in this study
View article: Table S3 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S3 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
GBM5K Library Composition. Gene list and Source for inclusion in library (see "Key" tab)
View article: Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
DESEQ2 analysis of control vs Ptk2 knockout mouse GBM tumor samples
View article: Table S2 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S2 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Sequence of qPCR primers used in this study.
View article: Table S6 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S6 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Normalized Bayes Factor Scores for GSC and GBM cell line screens
View article: Cell cycle duration determines oncogenic transformation capacity
Cell cycle duration determines oncogenic transformation capacity Open
Oncogenic mutations are widespread in normal human tissues1. Similarly, in murine chimeras, cells carrying an oncogenic lesion contribute normal cells to adult tissues without causing cancer2-4. How lineages that escape cancer via normal d…
View article: Identification of Injury-Response State Determinants in Glioblastoma Stem Cells
Identification of Injury-Response State Determinants in Glioblastoma Stem Cells Open
Glioblastoma (GBM) is a common and highly lethal type of primary brain tumor in adults. Therapeutic failure is partly attributed to a fraction of Glioblastoma Stem Cells (GSCs) that show high levels of heterogeneity and plasticity. GSCs ex…
View article: Table S3 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S3 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
GBM5K Library Composition. Gene list and Source for inclusion in library (see "Key" tab)
View article: Table S1 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S1 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Sequence of gRNAs used in this study
View article: Table S5 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S5 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
qBF scores GSC screens vs Nonmalignant control screens
View article: Table S4 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S4 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
normalized Bayes Factor scores, essentiality calls and subtype scores from GBM5K and TKOv3 screens
View article: Table S2 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S2 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Sequence of qPCR primers used in this study.
View article: Table S6 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S6 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
Normalized Bayes Factor Scores for GSC and GBM cell line screens
View article: Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
DESEQ2 analysis of control vs Ptk2 knockout mouse GBM tumor samples
View article: Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities
Table S7 from Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities Open
DESEQ2 analysis of control vs Ptk2 knockout mouse GBM tumor samples