Daniel Sedding
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View article: Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1
Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1 Open
Myocardial ischemia/reperfusion (I/R) injury causes cardiomyocyte death and exacerbates inflammation. Emerging evidence implicates extracellular RNA (eRNA) and tumor necrosis factor-α (TNF-α) as key mediators. We hypothesize that eRNA rele…
View article: Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation
Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation Open
Background Vascular restenosis resulting from neointima formation significantly limits the efficacy of percutaneous interventional therapies compared with bypass surgery. The adventitial layer is involved in neointima formation, but the de…
View article: Clinical staging to guide management of metabolic disorders and their sequelae: a European Atherosclerosis Society consensus statement
Clinical staging to guide management of metabolic disorders and their sequelae: a European Atherosclerosis Society consensus statement Open
Obesity rates have surged since 1990 worldwide. This rise is paralleled by increases in pathological processes affecting organs such as the heart, liver, and kidneys, here termed systemic metabolic disorders (SMDs). For clinical management…
View article: Allostatic load and its determinants in a German sample—Results from the Carla cohort
Allostatic load and its determinants in a German sample—Results from the Carla cohort Open
Background Allostatic load (AL) is a surrogate of the physiological response to stress and reflects the ‘wear and tear’ on the body. Previous studies indicated that socioeconomic and behavioral determinants influence AL, which in turn is a…
View article: Complete revascularization versus culprit-lesion only PCI in patients with NSTEMI and multivessel disease – Design and rationale of the randomized COMPLETE-NSTEMI trial
Complete revascularization versus culprit-lesion only PCI in patients with NSTEMI and multivessel disease – Design and rationale of the randomized COMPLETE-NSTEMI trial Open
CLINICALTRIALS.GOV: NCT05786131.
View article: Duration of mild acute SARS-CoV-2 infections with Omicron depending on previous vaccinations and infections – Using data of the German DigiHero cohort study from post-pandemic winters 2022/2023 and 2023/2024
Duration of mild acute SARS-CoV-2 infections with Omicron depending on previous vaccinations and infections – Using data of the German DigiHero cohort study from post-pandemic winters 2022/2023 and 2023/2024 Open
There was no indication of reduced duration of symptoms during short mild infections depending on the number of vaccinations and time since the last SARS-CoV-2 vaccination or infection. A prior SARS-CoV-2 infection was protective against p…
View article: Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach
Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach Open
Senescent endothelial cells (EC) are key players in the pathophysiology of cardiovascular diseases and are characterized by a reduced angiogenic and regenerative potential. Therefore, targeting these cells has been suggested as an effectiv…
View article: Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease
Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease Open
L-citrulline and, when ADMA levels are pathological, H4Bip are effective nutritional interventions in patients with PAD warranting further confirmatory trials.
View article: Prophylactic use of inotropic agents for the prevention of low cardiac output syndrome and mortality in adults undergoing cardiac surgery
Prophylactic use of inotropic agents for the prevention of low cardiac output syndrome and mortality in adults undergoing cardiac surgery Open
Prophylactic treatment with levosimendan may reduce the incidence of LCOS and probably reduces associated mortality in adult patients undergoing cardiac surgery when compared to placebo only. Conclusions on the benefits and harms of other …
View article: Post-COVID recovery is faster after an infection with the SARS-CoV-2 Omicron variant: a population-based cohort study
Post-COVID recovery is faster after an infection with the SARS-CoV-2 Omicron variant: a population-based cohort study Open
Purpose Post-COVID-19 condition (PCC) poses a substantial burden to affected individuals, health care systems, and society as a whole. We examined factors associated with recovery from PCC, focusing on the vaccination status prior to infec…
View article: Child and Adolescent Mental Health in a Period of Fewer COVID-19-Related Restrictions in an Urban Population in Germany
Child and Adolescent Mental Health in a Period of Fewer COVID-19-Related Restrictions in an Urban Population in Germany Open
The aim of this study was to assess the mental health situation of children and adolescents during a period of less strict COVID-19-pandemic-related measures after the first pandemic wave. This cross-sectional study was conducted in July 2…
View article: An artificial intelligence-driven 3D-vectorcardiography technique for non-invasive prediction of obstructive coronary artery disease: a prospective study
An artificial intelligence-driven 3D-vectorcardiography technique for non-invasive prediction of obstructive coronary artery disease: a prospective study Open
Cardiovascular disease, particularly coronary artery disease (CAD), is the leading cause of death in industrialized nations. Invasive coronary angiography is the diagnostic gold standard for ischemic heart disease but is costly, and comple…
View article: Impact of QRS misclassifications on heart-rate-variability parameters (results from the CARLA cohort study)
Impact of QRS misclassifications on heart-rate-variability parameters (results from the CARLA cohort study) Open
Background Heart rate variability (HRV), an important marker of autonomic nervous system activity, is usually determined from electrocardiogram (ECG) recordings corrected for extrasystoles and artifacts. Especially in large population-base…
View article: Left ventricular structure and function following renal sympathetic denervation in patients with HFpEF: an echocardiographic 9-year long-term follow-up
Left ventricular structure and function following renal sympathetic denervation in patients with HFpEF: an echocardiographic 9-year long-term follow-up Open
Background High blood pressure is a major risk factor for cardiac remodeling and left ventricular hypertrophy, increasing cardiovascular risk and leading to heart failure with preserved ejection fraction (HFpEF). Since renal sympathetic de…
View article: Deeper insights into heart failure with preserved ejection fraction through rna-sequencing of circulating endothelial cells - advanced protocol establishment enables complete transcriptome analysis
Deeper insights into heart failure with preserved ejection fraction through rna-sequencing of circulating endothelial cells - advanced protocol establishment enables complete transcriptome analysis Open
Funding Acknowledgements None. Heart failure with preserved ejection fraction (HFpEF) continues to pose a significant challenge with a bleak prognosis and a rising incidence, particularly among the aging population in Western countries. An…
View article: MiR-92b-3p modulates apoptosis in smooth muscle cells through BCL2L11 regulation, unravelling novel therapeutic strategies for unstable plaques
MiR-92b-3p modulates apoptosis in smooth muscle cells through BCL2L11 regulation, unravelling novel therapeutic strategies for unstable plaques Open
Funding Acknowledgements None. Smooth muscle cell (SMC) apoptosis is a contributory factor to plaque rupture in atherosclerosis, thereby promoting plaque destabilization through various mechanisms such as thrombogenic activation and plaque…
View article: Enhancing cellular regeneration through targeted pharmacological reprogramming of senescent endothelial cells
Enhancing cellular regeneration through targeted pharmacological reprogramming of senescent endothelial cells Open
Funding Acknowledgements None. Background Senescent endothelial cells (EC) are key players in the pathophysiology of cardiovascular diseases and characterized by a reduced angiogenic and regenerative potential. Therefore, reversing EC sene…
View article: MicroRNA-31-5p is upregulated during neointima formation and influences human coronary artery smooth muscle cell functions by regulating PIAS3 and DKK1
MicroRNA-31-5p is upregulated during neointima formation and influences human coronary artery smooth muscle cell functions by regulating PIAS3 and DKK1 Open
Funding Acknowledgements None. Background and purpose MicroRNAs (miRs) have emerged as potential therapeutic targets in cardiovascular disease, given their ability to modulate multiple signaling pathways and cellular processes. Neointima f…
View article: MiR-32-5p as potential key mediator of vascular remodeling enhances cell proliferation of vascular smooth muscle cells
MiR-32-5p as potential key mediator of vascular remodeling enhances cell proliferation of vascular smooth muscle cells Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): University Hospital Halle, Martin-Luther-University Halle-Wittenberg Background and purpose The dysfunctionality of endotheli…
View article: MicroRNA-127-3p regulates inflammatory response in injury-induced vascular remodeling and cellular senescence in vascular smooth muscle cells through mTor
MicroRNA-127-3p regulates inflammatory response in injury-induced vascular remodeling and cellular senescence in vascular smooth muscle cells through mTor Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Martin-Luther-Universität Halle-Wittenberg Background and Purpose The accumulation of senescent cells in the vasculature cont…
View article: NOS recoupling with L-citrulline, folate, and vericiguat in a NOX5-positive subgroup of HFpEF patients: A Phase IIa proof-of-concept trial
NOS recoupling with L-citrulline, folate, and vericiguat in a NOX5-positive subgroup of HFpEF patients: A Phase IIa proof-of-concept trial Open
To test the hypothesis of a causal mechanism subtype in HFpEF related to uncoupled NO synthase and apo-sGC, a monocentric, prospective, randomized, standard treatment-controlled, open-label, phase IIa, proof-of-concept clinical trial (REPO…
View article: The contribution of SARS-CoV-2 to the burden of acute respiratory infections in winter season 2022/2023: results from the DigiHero study
The contribution of SARS-CoV-2 to the burden of acute respiratory infections in winter season 2022/2023: results from the DigiHero study Open
Our estimate for ARI related to SARS-CoV-2 is consistent with the difference in all ARI between pre-pandemic years and 2022/2023. This additional burden should be considered, particularly, with respect to the implications for the work forc…
View article: Isolation of circulating endothelial cells provides tool to determine endothelial cell senescence in blood samples
Isolation of circulating endothelial cells provides tool to determine endothelial cell senescence in blood samples Open
Circulating endothelial cells (CEC) are arising as biomarkers for vascular diseases. However, whether they can be utilized as markers of endothelial cell (EC) senescence in vivo remains unknown. Here, we present a protocol to isolate circu…
View article: Differential associations between SARS-CoV-2 infection, perceived burden of the pandemic and mental health in the German population-based cohort for digital health research
Differential associations between SARS-CoV-2 infection, perceived burden of the pandemic and mental health in the German population-based cohort for digital health research Open
Introduction Understanding the potential adverse effects of the Covid-19-pandemic remains a challenge for public mental health. In this regard, the differentiation between potential consequences of actual infection with SARS-CoV-2 and the …