Daniel Selchen
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View article: First-Line Use of Higher-Efficacy Disease-Modifying Therapies in Multiple Sclerosis: Canadian Consensus Recommendations
First-Line Use of Higher-Efficacy Disease-Modifying Therapies in Multiple Sclerosis: Canadian Consensus Recommendations Open
Multiple sclerosis (MS) is characterized by focal inflammatory activity in the central nervous system and a diffuse, compartmentalized inflammation that is the primary driver of neuroaxonal damage and worsening disability. It is now recogn…
View article: Low-Field (64 mT) Portable MRI for Rapid Point-of-Care Diagnosis of Dissemination in Space in Patients Presenting with Optic Neuritis
Low-Field (64 mT) Portable MRI for Rapid Point-of-Care Diagnosis of Dissemination in Space in Patients Presenting with Optic Neuritis Open
In patients with optic neuritis, pMRI exhibited moderate concordance, moderate sensitivity, and high specificity for DIS compared with cMRI. Its integration into the MS clinic reduced the time from symptom onset to MRI. Further studies are…
View article: Health Canada Drug Approval Process: A Barrier to Personalized Care in Multiple Sclerosis
Health Canada Drug Approval Process: A Barrier to Personalized Care in Multiple Sclerosis Open
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View article: Practical guidance for managing patients with moderate-to-severe ulcerative colitis using small molecule therapies
Practical guidance for managing patients with moderate-to-severe ulcerative colitis using small molecule therapies Open
Ulcerative colitis (UC) is a severe and debilitating illness that affects the quality of life and physical health of many Canadians. Given the dynamic and progressive nature of the disease, advanced therapies are required to support its lo…
View article: CJN volume 50 issue 2 Cover and Front matter
CJN volume 50 issue 2 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Acute central nervous system inflammation following COVID-19 vaccination: An observational cohort study
Acute central nervous system inflammation following COVID-19 vaccination: An observational cohort study Open
Background: Reports suggest a potential association between coronavirus disease 2019 (COVID-19) vaccines and acute central nervous system (CNS) inflammation. Objective: The main objective of this study is to describe features of acute CNS …
View article: Acute Central Nervous System Demyelination Following COVID-19 Vaccination
Acute Central Nervous System Demyelination Following COVID-19 Vaccination Open
Objective To describe features of central nervous system (CNS) demyelinating events following vaccination against coronavirus disease 19 (COVID-19). Background Several reports suggest a potential association between COVID-19 vaccines and a…
View article: Expert Opinion On COVID-19 Vaccines and Cladribine Tablets in MS: A Plain Language Summary
Expert Opinion On COVID-19 Vaccines and Cladribine Tablets in MS: A Plain Language Summary Open
Overall, people with MS taking cladribine tablets should receive the COVID-19 vaccine to protect themselves, unless advised differently by their healthcare provider.
View article: Complement Inhibition in Myasthenia Gravis and Neuromyelitis Optica Spectrum Disorder
Complement Inhibition in Myasthenia Gravis and Neuromyelitis Optica Spectrum Disorder Open
The complement system is a tightly controlled signaling network that plays a role in innate immune surveillance. However, abnormal signaling through this pathway contributes to tissue damage in several inflammatory, autoimmune, and degener…
View article: Expert Opinion on COVID-19 Vaccination and the Use of Cladribine Tablets in Clinical Practice
Expert Opinion on COVID-19 Vaccination and the Use of Cladribine Tablets in Clinical Practice Open
Background Gaps in current evidence and guidance leave clinicians with unanswered questions on the use of cladribine tablets for the treatment of multiple sclerosis (MS) in the era of the COVID-19 pandemic, in particular relating to COVID-…
View article: Cognitive impairment, the central vein sign, and paramagnetic rim lesions in RIS
Cognitive impairment, the central vein sign, and paramagnetic rim lesions in RIS Open
Objective: The central vein sign (CVS) and “paramagnetic rim lesions” (PRL) are emerging imaging biomarkers in multiple sclerosis (MS) reflecting perivenular demyelination and chronic, smoldering inflammation. The objective of this study w…
View article: Expert opinion on COVID-19 vaccination and the use of cladribine tablets in clinical practice
Expert opinion on COVID-19 vaccination and the use of cladribine tablets in clinical practice Open
Background: Gaps in current evidence and guidance leave clinicians with unanswered questions on the use of cladribine tablets for the treatment of multiple sclerosis (MS) in the era of the COVID-19 pandemic, in particular relating to COVID…
View article: Expert opinion on the use of cladribine tablets in clinical practice
Expert opinion on the use of cladribine tablets in clinical practice Open
Background: Gaps in current product labels and a lack of detailed clinical guidelines leaves clinicians’ questions on the practical management of patients receiving cladribine tablets for the treatment of relapsing multiple sclerosis (MS) …
View article: Therapeutic Inertia in Multiple Sclerosis Care: A Study of Canadian Neurologists
Therapeutic Inertia in Multiple Sclerosis Care: A Study of Canadian Neurologists Open
Introduction: According to previous studies, therapeutic inertia (TI) may affect 7 out of 10 physicians who care for MS patients, particularly in countries where clinical guidelines are not widely used. Limited information is available on …
View article: CJN volume 45 issue 5 Cover and Front matter
CJN volume 45 issue 5 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Managing Multiple Sclerosis: Treatment Initiation, Modification, and Sequencing
Managing Multiple Sclerosis: Treatment Initiation, Modification, and Sequencing Open
Recent therapeutic advances in the management of multiple sclerosis (MS) have raised questions about the selection of appropriate patient candidates for various treatments and, if the plan is to move from one treatment to another, the appr…
View article: Quantitative spinal cord MRI in radiologically isolated syndrome
Quantitative spinal cord MRI in radiologically isolated syndrome Open
The SC demonstrates minimal microstructural changes suggestive of demyelination and inflammation in RIS. These findings are in contrast to established MS and raise the possibility that the SC may play an important role in triggering clinic…
View article: Smoking cessation and outcome after ischemic stroke or TIA
Smoking cessation and outcome after ischemic stroke or TIA Open
Cessation of cigarette smoking after an ischemic stroke or TIA was associated with significant health benefits over 4.8 years in the IRIS trial cohort.
View article: Decision-making in Multiple Sclerosis: The Role of Aversion to Ambiguity for Therapeutic Inertia among Neurologists (DIScUTIR MS)
Decision-making in Multiple Sclerosis: The Role of Aversion to Ambiguity for Therapeutic Inertia among Neurologists (DIScUTIR MS) Open
TI is a common phenomenon affecting nearly 7 out of 10 physicians caring for MS patients. Higher prevalence of TI was associated with physician's strong aversion to ambiguity and low tolerance of uncertainty.
View article: Decision making under uncertainty, therapeutic inertia, and physicians’ risk preferences in the management of multiple sclerosis (DIScUTIR MS)
Decision making under uncertainty, therapeutic inertia, and physicians’ risk preferences in the management of multiple sclerosis (DIScUTIR MS) Open
The present study applies an innovative approach by combining tools to assess medical decisions with experiments from Neuroeconomics that applies to common scenarios in MS care. Our results will help advance the field by providing a better…