Daniel Sforza
YOU?
Author Swipe
View article: 3D Imaging of Proton FLASH Radiation Using a Multi-Detector Small Animal PET System
3D Imaging of Proton FLASH Radiation Using a Multi-Detector Small Animal PET System Open
Objectives: Ultra-high dose-rate FLASH radiotherapy has demonstrated strong potential in reducing normal tissue toxicity while maintaining effective tumor control. However, its underlying radiobiological mechanisms remain unclear, highligh…
View article: PRECLINICAL STUDY OF COGNITIVE IMPAIRMENT FOLLOWING IMAGE-GUIDED PROTON FLASH
PRECLINICAL STUDY OF COGNITIVE IMPAIRMENT FOLLOWING IMAGE-GUIDED PROTON FLASH Open
View article: INITIAL EXPERIENCE WITH PENCIL BEAM SCANNING AND A CLINICAL SYNCHROTRON SYSTEM FOR PRECLINICAL ULTRA-HIGH DOSE RATE PROTON IRRADIATION
INITIAL EXPERIENCE WITH PENCIL BEAM SCANNING AND A CLINICAL SYNCHROTRON SYSTEM FOR PRECLINICAL ULTRA-HIGH DOSE RATE PROTON IRRADIATION Open
View article: Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment
Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment Open
Pre-clinical animal studies evaluating the ‘flash effect’ caused by ultra-high dose rate (≥40 Gy/s) favorably spares normal tissue from radiation-caused toxicity while maintaining anti-tumor effects like conventional (CONV) radiation. The …
View article: Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment
Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment Open
Pre-clinical animal studies evaluating the ‘flash effect’ caused by ultra-high dose rate (>=40Gy/s) favorably spares normal tissue from radiation-caused toxicity while maintaining anti-tumor effect like conventional (CONV) radiation. Th…
View article: Dose, dose rate and split dose impacts murine skin responses following photon FLASH irradiation
Dose, dose rate and split dose impacts murine skin responses following photon FLASH irradiation Open
These results demonstrate it is feasible to deliver photon FLASH exposures with sparing consistent with observations from previous studies using proton and electron beams. Dose, average dose rate and beam structure are key parameters that …
View article: Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment
Leveraging the Immune Response from LIFE Biomaterial and Photon-Flash in Pre-Clinical Pancreatic Cancer Treatment Open
Pre-clinical animal studies evaluating the ‘flash effect’ caused by ultra-high dose rate (>=40Gy/s) favorably spares normal tissue from radiation-caused toxicity while maintaining anti-tumor effect like conventional (CONV) radiation. Th…
View article: Commissioning of a 142.4 MeV ultra‐high dose rate (UHDR) proton beamline in a synchrotron‐based proton therapy system
Commissioning of a 142.4 MeV ultra‐high dose rate (UHDR) proton beamline in a synchrotron‐based proton therapy system Open
Background Recent studies suggest that radiotherapy at ultrahigh dose rates (>40 Gy/s, FLASH) offers normal tissue sparing effects while maintaining tumor control. There is significant interest in preclinical studies investigating the mech…
View article: Dosimetric commissioning of small animal FLASH radiation research platform
Dosimetric commissioning of small animal FLASH radiation research platform Open
Objective. The FLASH-SARRP, a new small animal radiation research platform has been designed to support conventional, high and ultrahigh dose-rate kV x-rays for preclinical research. This self-shielded system features two high-capacity x-r…
View article: Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research
Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research Open
Background: This study aims to present the feasibility of developing a synchrotron-based proton ultra-high dose rate (UHDR) pencil beam scanning (PBS) system. Methods: The RF extraction power in the synchrotron system was increased to gene…
View article: Characterization of a commercial bioluminescence tomography‐guided system for pre‐clinical radiation research
Characterization of a commercial bioluminescence tomography‐guided system for pre‐clinical radiation research Open
Background Widely used Cone‐beam computed tomography (CBCT)‐guided irradiators have limitations in localizing soft tissue targets growing in a low‐contrast environment. This hinders small animal irradiators achieving precise focal irradiat…
View article: Dosimetric characterization of a rotating anode x‐ray tube for FLASH radiotherapy research
Dosimetric characterization of a rotating anode x‐ray tube for FLASH radiotherapy research Open
Purpose Most current research toward ultra‐high dose rate (FLASH) radiation is conducted with advanced proton and electron accelerators, which are of limited accessibility to basic laboratory research. An economical alternative to charged …
View article: FLASH Effects Induced by Orthovoltage X-Rays
FLASH Effects Induced by Orthovoltage X-Rays Open
View article: Quantitative Bioluminescence Tomography for In Vivo Volumetric-Guided Radiotherapy
Quantitative Bioluminescence Tomography for In Vivo Volumetric-Guided Radiotherapy Open
View article: Characterization of a Commercial Bioluminescence Tomography System for Pre-Clinical Radiation Research
Characterization of a Commercial Bioluminescence Tomography System for Pre-Clinical Radiation Research Open
View article: Development of a Mobile Fluorescence Tomography-guided System for Pre-clinical Radiotherapy Research
Development of a Mobile Fluorescence Tomography-guided System for Pre-clinical Radiotherapy Research Open
We proposed to build a mobile fluorescence tomography (mFT) system as an image-guided platform for pre-clinical radiotherapy research. The mFT system is expected to localize functional target/tumor, guide irradiation, and provide longitudi…