Daniel Shepshelovich
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View article: Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review
Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review Open
To conclude, reduced Cmax and delayed tmax of drugs co-administered with GLP1RAs are consistent with the known delayed gastric output by the latter. Nevertheless, the overall drug exposure was not considered clinicall…
View article: Rate of Correction and All-Cause Mortality in Patients With Severe Hypernatremia
Rate of Correction and All-Cause Mortality in Patients With Severe Hypernatremia Open
Importance Hypernatremia is common among hospitalized patients and is associated with high mortality rates. Current guidelines suggest avoiding fast correction rates but are not supported by robust data. Objective To investigate whether th…
View article: A tailored phase I-specific patient-reported outcome (PRO) survey to capture the patient experience of symptomatic adverse events
A tailored phase I-specific patient-reported outcome (PRO) survey to capture the patient experience of symptomatic adverse events Open
Background Patient perspectives are fundamental to defining tolerability of investigational anti-neoplastic therapies in clinical trials. Phase I trials present a unique challenge in designing tools for efficiently collecting patient-repor…
View article: Massive splenomegaly
Massive splenomegaly Open
View article: Systematic Review and Meta-analysis of Foodborne Tickborne Encephalitis, Europe, 1980–2021
Systematic Review and Meta-analysis of Foodborne Tickborne Encephalitis, Europe, 1980–2021 Open
Tick-borne encephalitis (TBE) is a viral infection of the central nervous system that occurs in many parts of Europe and Asia. Humans mainly acquire TBE through tick bites, but TBE occasionally is contracted through consuming unpasteurized…
View article: Evaluation of the patient experience of symptomatic adverse events on Phase I clinical trials using PRO-CTCAE
Evaluation of the patient experience of symptomatic adverse events on Phase I clinical trials using PRO-CTCAE Open
View article: Emergency Use Authorizations of COVID-19–Related Medical Products
Emergency Use Authorizations of COVID-19–Related Medical Products Open
This cross-sectional study assesses the quality of the process to authorize diagnostic tests, medical devices, and drugs for COVID-19.
View article: Rapid 8‐Zone Lung Ultrasound Protocol is Comparable to a Full 12‐Zone Protocol for Outcome Prediction in Hospitalized <scp>COVID</scp>‐19 Patients
Rapid 8‐Zone Lung Ultrasound Protocol is Comparable to a Full 12‐Zone Protocol for Outcome Prediction in Hospitalized <span>COVID</span>‐19 Patients Open
Objectives Safety precautions limit the clinical assessment of hospitalized Coronavirus disease 2019 (COVID‐19) patients. The minimal exposure required to perform lung ultrasound (LUS) paired with its high accuracy, reproducibility, and av…
View article: Concordance between the results of randomized and non-randomized interventional clinical trials assessing the efficacy of drugs for COVID-19: a cross-sectional study
Concordance between the results of randomized and non-randomized interventional clinical trials assessing the efficacy of drugs for COVID-19: a cross-sectional study Open
Objectives To assess whether results of observational studies of potential anti-COVID-19 drugs were reproduced in subsequent randomized controlled trials (RCTs). Methods This was a retrospective cross-sectional study, including studies pub…
View article: Cost Analysis of New Antibiotics to Treat Multidrug-Resistant Bacterial Infections: Mind the Gap
Cost Analysis of New Antibiotics to Treat Multidrug-Resistant Bacterial Infections: Mind the Gap Open
Using newly approved antibiotic drugs for MDR infections carries a large incremental cost. Additional data to support survival benefit of these drugs are required to justify the price differences. Subgroups of patients who would benefit mo…
View article: Incidence of lung cancer following pneumonia in smokers: a population-based study
Incidence of lung cancer following pneumonia in smokers: a population-based study Open
Summary Background Pneumonia is more common in smokers compared with non-smokers. A high 1-year prevalence of lung cancer following hospitalization for pneumonia was demonstrated in heavy smokers. Aim To assess the association between hosp…
View article: Underreporting of Symptomatic Adverse Events in Phase I Clinical Trials
Underreporting of Symptomatic Adverse Events in Phase I Clinical Trials Open
Background Clinician reporting of symptomatic adverse events (AEs) in phase I trials uses the Common Terminology Criteria for Adverse Events (CTCAE). The utility of the patient-reported outcomes (PROs) version of the CTCAE (PRO-CTCAE) in t…
View article: The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients
The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients Open
View article: Vaccine safety – is the SARS-CoV-2 vaccine any different?
Vaccine safety – is the SARS-CoV-2 vaccine any different? Open
Vaccines have changed modern medicine, and are a mainstay in reducing morbidity and mortality from infections. Our research group recently published a study in which we found that vaccines approved by the US Food and Drugs Administration w…
View article: Effect of liver fibrosis on survival in patients with intrahepatic cholangiocarcinoma: a SEER population-based study
Effect of liver fibrosis on survival in patients with intrahepatic cholangiocarcinoma: a SEER population-based study Open
Patients with iCCA and advanced liver fibrosis have an increased risk of both overall and cancer-specific mortality compared to patients with earlier stages of fibrosis.
View article: Assessment of Data Sources That Support US Food and Drug Administration Medical Devices Safety Communications
Assessment of Data Sources That Support US Food and Drug Administration Medical Devices Safety Communications Open
In this cross-sectional study, the most common source of initial safety signals that triggered MDSCs was direct reports of real-world adverse events to the FDA through the MDR program. The delayed detection of postmarketing adverse events …
View article: Response to Letter to the Editor From Min Gong et al: “Risk for Infections During Treatment With Denosumab for Osteoporosis: A Systematic Review and Meta-analysis”
Response to Letter to the Editor From Min Gong et al: “Risk for Infections During Treatment With Denosumab for Osteoporosis: A Systematic Review and Meta-analysis” Open
View article: Effect of Ticagrelor on Reducing the Risk of Gram-Positive Infections in Patients With Acute Coronary Syndrome
Effect of Ticagrelor on Reducing the Risk of Gram-Positive Infections in Patients With Acute Coronary Syndrome Open
In light of recent studies describing the antibacterial properties of ticagrelor, the association between treatment with ticagrelor and subsequent risk for infection following acute coronary syndrome (ACS) is taking on increased importance…
View article: Response to Letter to the Editor: “Risk for Infections During Treatment with Denosumab for Osteoporosis: a Systematic Review and Meta-analysis”
Response to Letter to the Editor: “Risk for Infections During Treatment with Denosumab for Osteoporosis: a Systematic Review and Meta-analysis” Open
View article: Author response for "Risk factors for high‐dose methotrexate associated acute kidney injury in patients with hematological malignancies"
Author response for "Risk factors for high‐dose methotrexate associated acute kidney injury in patients with hematological malignancies" Open
Points of View Bar charts and box plotsCreating a simple yet effective plot requires an understanding of data and tasks.
View article: Author response for "Risk factors for high‐dose methotrexate associated acute kidney injury in patients with hematological malignancies"
Author response for "Risk factors for high‐dose methotrexate associated acute kidney injury in patients with hematological malignancies" Open
View article: Attention to age: similar dosing regimens lead to different vancomycin levels among older and younger patients
Attention to age: similar dosing regimens lead to different vancomycin levels among older and younger patients Open
Background little is known on the clinical implications of vancomycin trough levels among older patients. Objective to evaluate the association between vancomycin levels and outcomes among older versus younger patients. Design retrospectiv…
View article: Implementation of PRO-CTCAE in phase I clinical trials identifies under reporting of adverse events
Implementation of PRO-CTCAE in phase I clinical trials identifies under reporting of adverse events Open
View article: Association Between Data Sources and US Food and Drug Administration Drug Safety Communications
Association Between Data Sources and US Food and Drug Administration Drug Safety Communications Open
This study describes sources of initial safety signals that that preceded US Food and Drug Administration (FDA) drug safety communications and examines their associations with drug characteristics and subsequent label changes.
View article: Investigation of Leukocyte Telomere Length and Genetic Variants in Chromosome 5p15.33 as Prognostic Markers in Lung Cancer
Investigation of Leukocyte Telomere Length and Genetic Variants in Chromosome 5p15.33 as Prognostic Markers in Lung Cancer Open
Background: Lung cancer remains the leading cause of cancer mortality with relatively few prognostic biomarkers. We investigated associations with overall survival for telomere length (TL) and genetic variation in chromosome 5p15.33, an es…
View article: PS1587 EDUCATIONAL INTERVENTION ENCOURAGING APPROPRIATE USE OF BLOOD TRANSFUSIONS – EXTENDED FOLLOW UP AND COMPARATIVE STUDY
PS1587 EDUCATIONAL INTERVENTION ENCOURAGING APPROPRIATE USE OF BLOOD TRANSFUSIONS – EXTENDED FOLLOW UP AND COMPARATIVE STUDY Open
Background: Restrictive transfusion strategy of packed red blood cells (PRBCs) has been shown to improve patient outcomes in a variety of clinical settings. Various educational measures have been shown to improve short‐term appropriateness…
View article: Body Mass Index (BMI), BMI Change, and Overall Survival in Patients With SCLC and NSCLC: A Pooled Analysis of the International Lung Cancer Consortium
Body Mass Index (BMI), BMI Change, and Overall Survival in Patients With SCLC and NSCLC: A Pooled Analysis of the International Lung Cancer Consortium Open
View article: Reporting infections in clinical trials of patients with haematological malignancies
Reporting infections in clinical trials of patients with haematological malignancies Open
View article: Deescalating Adjuvant Trastuzumab in HER2-Positive Early-Stage Breast Cancer: A Systemic Review and Meta-Analysis
Deescalating Adjuvant Trastuzumab in HER2-Positive Early-Stage Breast Cancer: A Systemic Review and Meta-Analysis Open
Background One year of adjuvant trastuzumab in combination with chemotherapy is the standard of care in early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Existing data on shortening trastuzumab treatment s…
View article: The association of vancomycin trough levels with outcomes among patients with methicillin-resistant Staphylococcus aureus (MRSA) infections: Retrospective cohort study
The association of vancomycin trough levels with outcomes among patients with methicillin-resistant Staphylococcus aureus (MRSA) infections: Retrospective cohort study Open
We found no association between vancomycin levels > = 15 mg/L and clinical outcomes in patients with MRSA infections. In patients with MRSA pneumonia, vancomycin levels > = 15 mg/L were associated with higher clinical success rates. Furthe…