Daniel Sieme
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View article: Mobility of sodium ions in agarose gels probed through combined single- and triple-quantum NMR
Mobility of sodium ions in agarose gels probed through combined single- and triple-quantum NMR Open
Funder: \n http://dx.doi.org/10.13039/501100001659\n Deutsche Forschungsgemeinschaft
View article: Quantitative description of the phase-separation behavior of the multivalent SLP65–CIN85 complex
Quantitative description of the phase-separation behavior of the multivalent SLP65–CIN85 complex Open
Biomolecular condensates play a major role in cell compartmentalization, besides membrane-enclosed organelles. The multivalent SLP65 and CIN85 proteins are proximal B-cell antigen receptor (BCR) signal effectors and critical for proper imm…
View article: Phase Separation Studied by Nuclear Magnetic Resonance
Phase Separation Studied by Nuclear Magnetic Resonance Open
Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like condensates are b…
View article: Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation
Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation Open
Signal transduction by the ligated B cell antigen receptor (BCR) depends on the preorganization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like condensate…
View article: Water dynamics in eutectic solutions of sodium chloride and magnesium sulfate: implications for life in Europa's subsurface ocean and ice shell
Water dynamics in eutectic solutions of sodium chloride and magnesium sulfate: implications for life in Europa's subsurface ocean and ice shell Open
NMR methods show greater water mobility in NaCl than MgSO 4 solution within eutectic melts, as likely to be found in the ice shell of Europa.
View article: Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation
Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation Open
Signal transduction by the ligated B cell antigen receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like condensat…
View article: Quantitative description of the phase separation behavior of the multivalent SLP65-CIN85 complex
Quantitative description of the phase separation behavior of the multivalent SLP65-CIN85 complex Open
Biomolecular condensates play a major role in cell compartmentalization, besides membrane-enclosed organelles. The multivalent SLP65 and CIN85 proteins are downstream B cell receptor (BCR)-signaling effectors, required for a proper immune …
View article: Maturation of amyloid β fibrils alters their molecular stability
Maturation of amyloid β fibrils alters their molecular stability Open
High-pressure NMR investigation of freshly prepared and aged amyloid-beta aggregates reveals that their stability against pressure-induced monomer dissociation is increased through maturation.
View article: Metal Binding to Sodium Heparin Monitored by Quadrupolar NMR
Metal Binding to Sodium Heparin Monitored by Quadrupolar NMR Open
Heparins and heparan sulfate polysaccharides are negatively charged glycosaminoglycans and play important roles in cell-to-matrix and cell-to-cell signaling processes. Metal ion binding to heparins alters the conformation of heparins and i…