Daniel Silverman
YOU?
Author Swipe
Brainstem circuit for sickness-induced sleep Open
Increased sleep induced by immune activation plays a crucial role in facilitating recovery from illness. However, the neural mechanisms underlying sickness-induced sleep remain poorly understood. Here, we identify a brainstem circuit origi…
View article: Oxygen-15 Labeled Water Positron Emission Tomography During External Trigeminal Nerve Stimulation
Oxygen-15 Labeled Water Positron Emission Tomography During External Trigeminal Nerve Stimulation Open
eTNS of bilateral supraorbital nerves (V1 division) generates significant activations during [15O]H2O PET imaging in regions associated with major depression and attention deficit disorder. Deactivations of cortical regions including the p…
Gallbladder Volvulus Open
Gallbladder volvulus is a very rare condition characterized by the torsion of the gallbladder on its mesentery with potentially serious complications when operative management is delayed. We present a case of an elderly woman diagnosed wit…
Brainstem circuit for sickness-induced sleep Open
SUMMARY Increased sleep induced by immune activation plays a crucial role in facilitating recovery from illness. However, the neural mechanisms underlying sickness-induced sleep remain poorly understood. Here, we identify a brainstem circu…
Activation of locus coeruleus noradrenergic neurons rapidly drives homeostatic sleep pressure Open
Homeostatic sleep regulation is essential for optimizing the amount and timing of sleep for its revitalizing function, but the mechanism underlying sleep homeostasis remains poorly understood. Here, we show that optogenetic activation of l…
View article: Dark continuous noise from visual pigment as a major mechanism underlying rod–cone difference in light sensitivity
Dark continuous noise from visual pigment as a major mechanism underlying rod–cone difference in light sensitivity Open
Retinal rods and cones underlie scotopic and photopic vision, respectively. Their pigments exhibit spontaneous isomerizations (quantal noise) in darkness due to intrinsic thermal energy. This quantal noise, albeit exceedingly low in rods, …
Evaluating the Effects of LDL Cholesterol Levels on Tau Visualization in [F‐18]flortaucipir PET Scans Open
Background Alzheimer's Disease and other neurodegenerative diseases are characterized by abnormal tau protein accumulation in the brain. PET imaging utilizing the [F‐18]flortaucipir tracer is a widely used method for visualizing such condi…
Significant Relationship Between Worsening Sleep and Declining Brain Metabolism in APOE4+ Individuals Open
Background We recently reported that subjects who had worsening sleep over time had a clear worsening of both memory and brain metabolism compared to subjects whose sleep improved over time, and metabolic decline was particularly significa…
Longitudinal Analysis of BCAA Levels and Hypometabolism in ApoE4‐Positive Alzheimer’s Patients Over A 48‐Month Period Open
Background Alzheimer’s Disease (AD) is a chronic, incurable neurodegenerative condition characterized by extensive systemic, cellular, and molecular abnormalities. One such aspect recent studies have highlighted is the reduction in plasma …
Restoration of locus coeruleus noradrenergic transmission during sleep Open
Sleep is indispensable for health and wellbeing, but its basic function remains elusive. The locus coeruleus (LC) powerfully promotes arousal by releasing noradrenaline. We found that noradrenaline transmission is reduced by prolonged wake…
View article: Dark continuous noise from mutant G90D-rhodopsin predominantly underlies congenital stationary night blindness
Dark continuous noise from mutant G90D-rhodopsin predominantly underlies congenital stationary night blindness Open
Congenital stationary night blindness (CSNB) is an inherited retinal disease that causes a profound loss of rod sensitivity without severe retinal degeneration. One well-studied rhodopsin point mutant, G90D-Rho, is thought to cause CSNB be…
Activation of locus coeruleus noradrenergic neurons rapidly drives homeostatic sleep pressure Open
Homeostatic sleep regulation is essential for optimizing the amount and timing of sleep, but the underlying mechanism remains unclear. Optogenetic activation of locus coeruleus noradrenergic neurons immediately increased sleep propensity f…
View article: CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma
CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma Open
Neuroblastoma (NB) can be a highly aggressive malignancy in children. However, the precise mechanisms driving NB tumorigenesis remain elusive. This study revealed the critical role of CREB phosphorylation in NB cell proliferation. By emplo…
Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission Open
Sleep interacts reciprocally with immune system activity, but its specific relationship with microglia—the resident immune cells in the brain—remains poorly understood. Here, we show in mice that microglia can regulate sleep through a mech…
Cognitively Impaired Subjects with Normal Total Cholesterol Using Lipophilic Statins Undergo Accelerated Decline in Regions Associated with Dementia and Those Regions are Predictive of Further Decline Over the Subsequent Two‐Year Period in a Multi‐Center Longitudinal Study Open
Background We recently reported that lipophilic statins, known to penetrate the blood‐brain barrier, were associated with accelerated decline in cortical regions known to decline in early Alzheimer’s Disease, in subjects with early Mild Co…
Relationship Between Memory and Brain Metabolism is Markedly Disordered in non‐Demented Patients Who Have Worsening Sleep Over Time Open
Background Disturbances in circadian rhythm often emerge during disease progression in patients with dementia. We recently reported that subjects with worsening sleep experienced significantly faster cerebral decline compared to subjects w…
Prospective Randomized Placebo‐Controlled Trial of Long‐Term Durability of Effect of One Year of Grape Consumption on Preventing Decline of Cerebral Function Open
Background Long‐term impact of one year of grape consumption on regional brain metabolism and associated neuropsychologic status was examined across multiple years of follow‐up. Method Twenty subjects (74.6±5.4 years) were randomized to co…
Examining the Effects of Hospitalization in ADNI Subjects: Characterizing Changes in Cognition and Glucose Metabolism Associated with Inpatient Hospital Stays Open
Background Risk of inpatient hospitalization and dementia both increase with age, though no study has attempted to characterize lasting changes in regional brain metabolism occurring after inpatient hospitalization. Method We screened adve…
Clinical, imaging, and biomarker evidence of amyloid- and tau-related neurodegeneration in late-onset epilepsy of unknown etiology Open
Accumulating evidence suggests amyloid and tau-related neurodegeneration may play a role in development of late-onset epilepsy of unknown etiology (LOEU). In this article, we review recent evidence that epilepsy may be an initial manifesta…
Microglia Regulate Sleep via Calcium-Dependent Modulation of Norepinephrine Transmission Open
Sleep interacts reciprocally with immune system activity, but its specific relationship with microglia – the resident immune cells in the brain – remains poorly understood. Here we show that microglia can regulate sleep through a mechanism…
Brain gray matter reduction and premature brain aging after breast cancer chemotherapy: a longitudinal multicenter data pooling analysis Open
Brain gray matter (GM) reductions have been reported after breast cancer chemotherapy, typically in small and/or cross-sectional cohorts, most commonly using voxel-based morphometry (VBM). There has been little examination of approaches su…
IVIG for Treatment-Resistant Psychosis For a Child with Turner Syndrome Open
Psychosis is defined as the presence of false beliefs or false perceptions. In children some causes of psychosis include psychiatric diagnosis such as schizophrenia and autism. However, it may also be secondary to medical conditions like v…
Don't rock the boat? Fears of conflict and support for protest in Iraq and beyond Open
Why do people support-or refrain from supporting-nonviolent protests for political change? The literature offers different answers to this question, but one variable that has received little attention is fears of protest unleashing violent…
View article: Cardiovascular baroreflex circuit moonlights in sleep control
Cardiovascular baroreflex circuit moonlights in sleep control Open
Sleep disturbances are strongly associated with cardiovascular diseases. Baroreflex, a basic cardiovascular regulation mechanism, is modulated by sleep-wake states. Here, we show that neurons at key stages of baroreflex pathways also promo…
Reply: Posterior Cingulate Involvement Does Not Argue Against LATE—And Who Said It Does? Open
REPLY: In response to our recent article evaluating the potential promise and current limitations of neuroimaging methods in contributing to the premortem diagnosis of limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) ence…
Is It Too Soon to Know When It’s LATE? Open
Developments over the past 2 decades in neuronuclear imaging and cerebrospinal fluid biomarker technologies for detecting dementia-related proteinopathies have made it increasingly clear how commonly Alzheimer disease (AD) has been clinica…