Daniel Snellings
YOU?
Author Swipe
View article: Cell-type-specific patterns and consequences of somatic mutation in development and aging brain
Cell-type-specific patterns and consequences of somatic mutation in development and aging brain Open
Elucidating the role of somatic mutations in cancer, healthy tissues, and aging depends on methods that can accurately characterize somatic mosaicism across different cell types, as well as assay their impact on cellular function. Current …
View article: Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations
Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations Open
View article: Gonomics: uniting high performance and readability for genomics with Go
Gonomics: uniting high performance and readability for genomics with Go Open
Summary Many existing software libraries for genomics require researchers to pick between competing considerations: the performance of compiled languages and the accessibility of interpreted languages. Go, a modern compiled language, provi…
View article: The diversity, evolution, and development of setal morphologies in bumble bees (Hymenoptera: Apidae: <i>Bombus</i> spp.)
The diversity, evolution, and development of setal morphologies in bumble bees (Hymenoptera: Apidae: <i>Bombus</i> spp.) Open
Bumble bees are characterized by their thick setal pile that imparts aposematic color patterns often used for species-level identification. Like all bees, the single-celled setae of bumble bees are branched, an innovation thought important…
View article: Adaptive sequence divergence forged new neurodevelopmental enhancers in humans
Adaptive sequence divergence forged new neurodevelopmental enhancers in humans Open
Searches for the genetic underpinnings of uniquely human traits have focused on human-specific divergence in conserved genomic regions, which reflects adaptive modifications of existing functional elements. However, the study of conserved …
View article: Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease
Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease Open
View article: A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis
A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis Open
View article: Developmental venous anomalies are a genetic primer for cerebral cavernous malformations
Developmental venous anomalies are a genetic primer for cerebral cavernous malformations Open
View article: Developmental Venous Anomalies are a Genetic Primer for Cerebral Cavernous Malformations
Developmental Venous Anomalies are a Genetic Primer for Cerebral Cavernous Malformations Open
Cerebral cavernous malformations (CCM) are a neurovascular anomaly that may occur sporadically in otherwise healthy individuals, or be inherited by autosomal dominant mutations in the genes that encode the proteins of the CCM signaling com…
View article: Cerebral Cavernous Malformation: From Mechanism to Therapy
Cerebral Cavernous Malformation: From Mechanism to Therapy Open
Cerebral cavernous malformations are acquired vascular anomalies that constitute a common cause of central nervous system hemorrhage and stroke. The past 2 decades have seen a remarkable increase in our understanding of the pathogenesis of…
View article: PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism Open
View article: Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1
Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1 Open
View article: Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the dif…
View article: Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Biallelic Loss of <i>ENG</i> or <i>ACVRL1</i>
Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Biallelic Loss of <i>ENG</i> or <i>ACVRL1</i> Open
Hereditary Hemorrhagic Telangiectasia (HHT) is a Mendelian disease characterized by vascular malformations including visceral arteriovenous malformations and mucosal telangiectasia. HHT is caused by loss-of-function mutations in one of 3 g…
View article: Additional file 7: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 7: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S6. 1876 gene ontology (GO) terms used for generating the heatmap. (XLSX 157 kb)
View article: Additional file 3: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 3: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S2. Top 20 genes by fold change for acute in vivo neurovascular units (NVUs), chronic in vivo NVUs and in vitro brain microvascular endothelial cells models (fold change |FC| ≥ 2; p < 0.05, false discovery rate corrected). (XLSX 18 k…
View article: Additional file 5: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 5: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S4. List of unique differentially expressed genes for all models according to the Venn diagram of the models (fold change |FC| ≥ 2.0; p < 0.05, false discovery rate corrected). (XLSX 745 kb)
View article: Additional file 9: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 9: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S8. List of 105 putative targets of mmu-miR-3472a within the differentially expressed genes common between acute and chronic in vivo neurovascular units. (XLSX 34 kb)
View article: Additional file 2: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 2: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S1. List of identified differentially expressed genes in each of three models (fold change |FC| ≥ 2, p < 0.05, false discovery rate corrected). (XLSX 643 kb)
View article: Additional file 4: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 4: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S3. List of enriched gene ontology functions for top 20 genes by fold change in each model (p < 0.05, false discovery rate corrected). (XLSX 14 kb)
View article: Additional file 8: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 8: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S7. List of gene ontology terms for lesional neurovascular units excluding in vitro brain microvascular endothelial cell (BMEC) differentially expressed genes (p < 0.01, false discovery rate (FDR) corrected) and in vitro BMECs (p < 0…
View article: Additional file 6: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Additional file 6: of Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations Open
Table S5. List of gene ontology terms for acute in vivo neurovascular units (NVUs) only and chronic in vivo NVUs only (p < 0.01, false discovery rate corrected). (XLSX 160 kb)
View article: Characterization of longitudinal canal tissue in the acorn barnacle Amphibalanus amphitrite
Characterization of longitudinal canal tissue in the acorn barnacle Amphibalanus amphitrite Open
The morphology and composition of tissue located within parietal shell canals of the barnacle Amphibalanus amphitrite are described. Longitudinal canal tissue nearly spans the length of side shell plates, terminating near the leading edge …
View article: Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells
Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells Open
Rationale: Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage within these malformations. …
View article: Cerebral Cavernous Malformations Develop through Clonal Expansion of Mutant Endothelial Cells
Cerebral Cavernous Malformations Develop through Clonal Expansion of Mutant Endothelial Cells Open
Rationale Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage within these malformations. O…