Explanipedia

Systematic Review and Meta-analysis on the Use of Aortic Size Index in Women with Infrarenal Abdominal Aortic Aneurysms Open

Laurence Bertrand, Anna Louise Pouncey, Daniel Caldeira, Ryan Gouveia e Melo, Isabelle Van Herzeele , et al. · 2025

Women undergo AAA repair at lower AD but higher ASI than men. Use of ASI suggests that women undergo diagnosis and treatment at a later stage of disease. This warrants reconsideration of current AD threshold recommendations and further in …

HowBP study: A cross-sectional study evaluating how blood pressure is usually measured Open

Daniel Caldeira, Beatriz García López, Fausto J. Pinto · 2025

The Placebo Effect in Chronic Thromboembolic Pulmonary Hypertension Trials: A Systematic Review and Meta-Analysis Open

Daniel Caldeira, D Cazeiro, Rui Plácido, Filipa Ferreira, Rita Calé , et al. · 2025

Introduction: Placebo-controlled studies are crucial in clinical trials, but the placebo effect can vary across conditions. We aimed to assess the placebo effect in chronic thromboembolic pulmonary hypertension (CTEPH) trials. Methods: We …

Association of Aspirin Use in Primary Prevention and Cardiovascular Events: A Retrospective Analysis of the VITAL Cohort Open

Daniel Caldeira, Mariana Alves, Nilza Gonçalves, João Costa, Joaquim J. Ferreira , et al. · 2025

Background: Aspirin is part of the therapeutic antithrombotic armamentarium for the management of patients with established clinically relevant atherosclerosis or thrombotic cardiovascular disease. Personalized medicine identifies those wh…

Biometria de sementes de Lofantera-da-Amazônia Open

Sebastião Marcos Silva Valentim, M Mendes, Daniel Caldeira, Petterson Baptista da Luz · 2025

Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis Open

Luísa Marques, Catarina Sousa, Fausto J. Pinto, Daniel Caldeira · 2024

Aims: Infective endocarditis (IE) is a serious heart valvular condition. While mitral valve prolapse (MVP) has been associated with an increased risk of IE, the magnitude of this association remains poorly quantified. This systematic revie…

World Heart Federation Cholesterol Roadmap: The Portuguese case Open

Ana Abreu, Hélder Dores, Lino Gonçalves, Fátima Franco, Conceição Silveira , et al. · 2024

Atherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability; effective cardiovascular (CV) risk prevention is fundamental. The World Heart Federation (WHF) Cholesterol Roadmap provides a framewo…

Role of myocardial microRNAs in the long-term ventricular remodelling of patients with aortic stenosis Open

André F. Gabriel, Marina C. Costa, Daniel Caldeira, Rui Plácido, J Rigueira , et al. · 2024

Aims We hypothesize that miRs are key players in the dynamics of the hypertrophy phenotype in aortic stenosis (AS) patients. In our study, we aimed to identify the transcriptional patterns (protein-coding transcripts and miRs) from myocard…

A Reconciliação da Medicação nos Cuidados de Saúde em Portugal Open

Pedro Benjamim, Luísa Prada, Andreia Lopes, Rita Avó-Baião, Daniel Caldeira · 2024

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A Narrative Review of Revascularization in Chronic Coronary Syndrome/Disease: Concepts and Misconceptions Open

Beatriz Nogueira-Garcia, Marta Vilela, Catarina Oliveira, Daniel Caldeira, A M Martins , et al. · 2024

Ischemic heart disease represents a significant global burden of morbidity and mortality. While revascularization strategies are well defined in acute settings, there are uncertainties regarding chronic coronary artery disease treatment. R…

How COVID-19 Can Damage the Heart? – Association of Cardiac Injury with COVID-19: A Narrative Review Open

Catarina Gregório, Daniel Caldeira, Dulce Brito, Rui Plácido, Fausto J. Pinto · 2024

Severe acute respiratory syndrome coronavirus 2 and its resulting disease, COVID-19, remain a significant public health concern. Cardiovascular injury is the second most common complication, following respiratory disease, encompassing cond…

Cardiovascular benefits of resistance exercise: It's time to prescribe Open

Hélder Dores, Mafalda Antunes, Daniel Caldeira, Hugo V. Pereira · 2024

In-hospital mortality of high-risk pulmonary embolism: a nationwide population-based cohort study in Portugal from 2010 to 2018 Open

Rita Calé, Raquel Ascenção, C. Bulhosa, Hélder Pereira, Margarida Borges , et al. · 2024

In Portugal, between 2010 and 2018, very few patients with PE developed high-risk forms of the disease, but the mortality rate among those patients was high. The low reperfusion rate could be associated with high in-hospital mortality and …

Arterial Hypertension, Heart Failure, Angina Pectoris, Myocardial Infarction, and Atrial Fibrillation after COVID-19: A Narrative Review Open

Dulce Brito, Daniel Caldeira, Catarina Gregório, Rui Plácido, Fausto J. Pinto · 2024

COVID-19 infection is associated with significant complications affecting multiple organs other than the respiratory system. In fact, there seems to be a bidirectional relation between cardiovascular disease and viral infection, as patient…

The association between asthma and atrial fibrillation: systematic review and meta-analysis Open

Beatriz Nogueira-Garcia, Mariana Alves, Fausto J. Pinto, Daniel Caldeira · 2024

Respiratory disease and atrial fibrillation (AF) frequent coexist, but the risk of AF among asthma patients is less characterized. Growing evidence suggest that AF shares with asthma a systemic inflammation background and asthma treatments…

CO165 Validation of High Risk Criteria in Medication Reconciliation in Major Orthopedic Surgery: A Delphi Study Open

José Luís Luque, Marcos Ulisses Cavalheiro, Paulo Silva, Helena Prior Filipe, Fátima Falcão , et al. · 2023

Incidence of muscle symptoms in placebo arm among statin-intolerant patients: a systematic review with meta-analysis Open

Rita Louro, Ryan Gouveia e Melo, Jorge Ruivo, Ana G. Almeida, Fausto J. Pinto , et al. · 2023

Statins are highly used in cardiovascular prevention. Statin intolerance is the most significant cause of decreased adherence, translating into a higher cardiovascular risk. This systematic review aims to estimate the incidence of muscle a…

Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic Open

Piotr Gajewski, Mikołaj Błaziak, Szymon Urban, Mateusz Garus, Frieder Braunschweig , et al. · 2023

The COVID-19 pandemic has had a significant impact on global public health, with long-term consequences that are still largely unknown. This study aimed to assess the data regarding acute cardiovascular hospital admissions in five European…

Incidence, Risk Factors, and Prognostic Impact of Type Ib Endoleak Following Endovascular Repair for Abdominal Aortic Aneurysm: Scoping Review Open

Gianmarco Zuccon, M. D’Oria, Frederico Bastos Gonçalves, Carla Fernández‐Prendes, Kevin Mani , et al. · 2023

The SAFEST study: The crucial role of primary health care in the diagnosis and management of atrial fibrillation Open

Pedro Gonçalves-Teixeira, Daniel Caldeira, Rui Baptista, Inês Zimbarra Cabrita, Margarida Nogueira , et al. · 2023

The SAFEST study: The crucial role of primary health care in the diagnosis and management of atrial fibrillation Estudo SAFEST ---o papel essencial dos Cuidados de Saúde Primários no diagnóstico e abordagem da fibrilhac ¸ão auricular Atria…

How to predict prognosis in patients with acute pulmonary embolism? Recent advances Open

Beatriz Valente Silva, Rita Calé, Miguel Nobre Menezes, Cláudia Jorge, Fausto J. Pinto , et al. · 2023

Pulmonary embolism (PE) is the third most frequent cardiovascular disease, characterized by a wide range of presentations and clinical courses. Prognostic assessment is a cornerstone of PE management as it determines the choice of both dia…

Cardiovascular effects of rivaroxaban in heart failure patients with sinus rhythm and coronary disease with and without diabetes: a retrospective international cohort study from COMMANDER-HF Open

Abhinav Sharma, Daniel Caldeira, Amir Razaghizad, Fausto J. Pinto, Dirk J. van Veldhuisen , et al. · 2023

Objectives COMMANDER-HF was a randomised trial comparing rivaroxaban 2.5 mg two times a day to placebo, in addition to antiplatelet therapy, in patients hospitalised for worsening heart failure with coronary artery disease and sinus rhythm…

Infective endocarditis risk in patients with bicuspid aortic valve: Systematic review and meta-analysis Open

S Couto Pereira, Ana Lobato Abrantes, P Silverio Antonio, P Morais, Catarina Sousa , et al. · 2023

Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic Open

Piotr Gajewski, Mikołaj Błaziak, Szymon Urban, Mateusz Garus, Freider Braunschweig , et al. · 2023

The COVID-19 pandemic has had a significant impact on global public health, with long-term consequences that are still largely unknown. This study aimed to assess the data regarding acute cardiovascular hospital admissions in five European…

Direct oral anticoagulants vs vitamin K antagonist on dementia risk in atrial fibrillation: systematic review with meta-analysis Open

Diogo R. Branco, Mariana Alves, Catarina Severiano e Sousa, João Costa, Joaquim J. Ferreira , et al. · 2023

Data monitoring committees in pediatric randomized controlled trials registered in ClinicalTrials.gov Open

Tiago Machado, Beatrice Mainoli, Daniel Caldeira, Joaquim J. Ferreira, Ricardo M. Fernandes · 2023

Background Data monitoring committees advise on clinical trial conduct through appraisal of emerging data to ensure participant safety and scientific integrity. While consideration of their use is recommended for trials performed with vuln…

Anticoagulação Oral e Incidência de Acidente Vascular Cerebral Associado a Fibrilhação Auricular em Portugal Continental: Um Estudo de Modelação Open

Raquel Ascenção, M Julio César Gil, F. Lourenço, Daniel Caldeira, M. Rosário Oliveira , et al. · 2023

Introdução: A fibrilhação auricular é a disritmia persistente mais prevalente, tendo um importante impacto social e económico. O objetivo principal deste estudo foi avaliar a associação entre a utilização de anticoagulantes orais e a incid…

Expert perspectives on strategic factors for the management and prevention of heart failure in Portugal Open

Daniel Caldeira, Dulce Brito, Carlos Aguíar, José Silva‐Cardoso, Cândida Fonseca , et al. · 2023

The acknowledgment of various strategic factors and their prioritization by experts made it possible to create and reinforce a range of new strategic recommendations for the management and prevention of HF.

The effect of catheter-based sham renal denervation in hypertension: systematic review and meta-analysis Open

Adriana Barrinha Fernandes, Cláudio David, Fausto J. Pinto, João Costa, Joaquim J. Ferreira , et al. · 2023

Background Renal denervation (RDN) has emerged in recent years as a possible treatment for hypertension. The first sham-controlled trial showed a small magnitude and non-significant in the blood pressure (BP) lowering effect, also due to a…

Polypill use for the prevention of cardiovascular disease: A position paper Open

Francisco Araújo, Daniel Caldeira, Carlos Aguíar, José Pedro Antunes, Nuno Cardim , et al. · 2023

Cardiovascular (CV) guidelines stress the need for global intervention to manage risk factors and reduce the risk of major vascular events. Growing evidence supports the use of polypill as a strategy to prevent cerebral and cardiovascular …

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