Daniel Soong
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View article: Activity-driven myelin sheath growth is mediated by mGluR5
Activity-driven myelin sheath growth is mediated by mGluR5 Open
Myelination by oligodendrocytes in the central nervous system is influenced by neuronal activity, but the molecular mechanisms by which this occurs have remained unclear. Here we employed pharmacological, genetic, functional imaging and op…
View article: High-resolution phenotypic screen in zebrafish identifies novel regulators of CNS axon diameter growth
High-resolution phenotypic screen in zebrafish identifies novel regulators of CNS axon diameter growth Open
Axon diameter varies up to 100-fold between distinct neurons in the central nervous system with larger axons exhibiting proportionally faster conduction velocity. Axon diameter influences myelination, can be dynamically regulated, which mi…
View article: Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons
Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons Open
Summary Central nervous system neurons have axons that vary over 100-fold in diameter. This diversity contributes to the regulation of myelination and conduction velocity along axons, which is critical for proper nervous system function. D…
View article: Figure S7 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S7 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Effects of MET signaling on susceptibility of cancer cells to NK cells.
View article: Figure S5 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S5 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
NK cell cytotoxicity against E0771-LG cells.
View article: Figure S6 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S6 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Detection and depletion of NK cells in mice with metastatic tumors.
View article: Data from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Data from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Metastasis-associated macrophages (MAM) promote persistent growth of breast cancer cells at the metastatic site and are, thus, an attractive therapeutic target to treat breast cancer metastasis, a leading cause of cancer-related death in w…
View article: Figure S5 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S5 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
NK cell cytotoxicity against E0771-LG cells.
View article: Figure S2 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S2 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Correlation between candidate gene expression and metastasis-free survival of breast cancer patients.
View article: Figure S7 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S7 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Effects of MET signaling on susceptibility of cancer cells to NK cells.
View article: Figure S6 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S6 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Detection and depletion of NK cells in mice with metastatic tumors.
View article: Figure S2 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S2 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Correlation between candidate gene expression and metastasis-free survival of breast cancer patients.
View article: Figure S1 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S1 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Microarray analysis to compare gene expression profile between E0771-parental and E0771-HML2 cells.
View article: Data from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Data from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Metastasis-associated macrophages (MAM) promote persistent growth of breast cancer cells at the metastatic site and are, thus, an attractive therapeutic target to treat breast cancer metastasis, a leading cause of cancer-related death in w…
View article: Figure S4 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S4 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Effects of MET signal on tumor cell apoptosis in vitro.
View article: Figure S4 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S4 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Effects of MET signal on tumor cell apoptosis in vitro.
View article: Figure S3 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S3 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Validation of antibodies used to detect HGF and immune cells.
View article: Figure S1 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S1 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Microarray analysis to compare gene expression profile between E0771-parental and E0771-HML2 cells.
View article: Figure S3 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Figure S3 from Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Validation of antibodies used to detect HGF and immune cells.
View article: <scp>DKK1</scp> drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with <scp>anti‐DKK1</scp> therapeutic <scp>DKN</scp>‐01
<span>DKK1</span> drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with <span>anti‐DKK1</span> therapeutic <span>DKN</span>‐01 Open
Background and aims Dickkopf‐1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear. Here, we show that DKK1 plays an immune regulatory role in vivo and inhibition r…
View article: Macrophages inhibit and enhance endometriosis depending on their origin
Macrophages inhibit and enhance endometriosis depending on their origin Open
Significance Endometriosis is a chronic, incurable inflammatory disorder impacting 190 million women worldwide. Immune cells called macrophages are implicated in promoting endometriosis. Macrophages have different origins and their origin …
View article: Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β
Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β Open
Background Metastatic breast cancer is a leading cause of cancer-related death in women worldwide. Infusion of natural killer (NK) cells is an emerging immunotherapy for such malignant tumors, although elimination of the immunosuppressive …
View article: Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF
Mammary Tumor Cells with High Metastatic Potential Are Hypersensitive to Macrophage-Derived HGF Open
Metastasis-associated macrophages (MAM) promote persistent growth of breast cancer cells at the metastatic site and are, thus, an attractive therapeutic target to treat breast cancer metastasis, a leading cause of cancer-related death in w…
View article: 1,25-Dihydroxyvitamin D3 Restrains CD4+ T Cell Priming Ability of CD11c+ Dendritic Cells by Upregulating Expression of CD31
1,25-Dihydroxyvitamin D3 Restrains CD4+ T Cell Priming Ability of CD11c+ Dendritic Cells by Upregulating Expression of CD31 Open
Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of …
View article: Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets Open
The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endome…
View article: AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer Open
Significance Basal-like/BRCA1-associated breast cancer (BC) is a very aggressive form of BC that frequently occurs in young women, with devastating effects. Since tailored therapies are lacking for this type of tumor, scientists and clinic…