Daniel Stengel
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View article: Exploring the impact of various zwitterionic surface modifications on the mucus diffusion and membrane permeability of lipid-based nanocarriers
Exploring the impact of various zwitterionic surface modifications on the mucus diffusion and membrane permeability of lipid-based nanocarriers Open
This study investigates the effect of structural differences among six zwitterionic surfactants on the performance of lipid-based nanoemulsions. Nanoemulsions were prepared using a standardized formulation approach to minimize compositiona…
View article: Assessing the potential of chlorido[N,N'-bis(salicylidene)-1,2-phenylenediamine]iron(III): Exploring delivery through lipid-based nanocarriers
Assessing the potential of chlorido[N,N'-bis(salicylidene)-1,2-phenylenediamine]iron(III): Exploring delivery through lipid-based nanocarriers Open
These findings suggest that LBNCs offer a promising platform for the oral delivery of Fe³⁺SP, with significant advantages over conventional delivery systems.
View article: Exploring glutathione-decorated micelles for drug delivery: A promise for enhanced cellular uptake
Exploring glutathione-decorated micelles for drug delivery: A promise for enhanced cellular uptake Open
This study aimed to evaluate the effect of thiolated micelles on the cellular uptake of their payload. Reduced and oxidized glutathione were covalently attached to palmitic acid via amide bond formation. Micelles formed with these thiolate…
View article: Evaluation of the dissociation behavior of hydrophobic ion pairs via HPLC analysis
Evaluation of the dissociation behavior of hydrophobic ion pairs via HPLC analysis Open
HPLC analysis offers a valuable method to study the dissociation of hydrophobic ion pairs in physiological relevant media.
View article: Nanostructured lipid carriers decorated with polyphosphate coated linear and loop cell-penetrating peptides
Nanostructured lipid carriers decorated with polyphosphate coated linear and loop cell-penetrating peptides Open
CPPs-NLCs coated with polyphosphate are a promising approach to overcome the polycationic dilemma and to enhance cellular uptake.
View article: Design of self-emulsifying oral delivery systems for semaglutide: reverse micelles versus hydrophobic ion pairs
Design of self-emulsifying oral delivery systems for semaglutide: reverse micelles versus hydrophobic ion pairs Open
It was the aim of this study to evaluate the potential of reverse micelles (RM) and hydrophobic ion pairs (HIP) for incorporation of semaglutide into self-emulsifying oral drug delivery systems. Reverse micelles loaded with semaglutide wer…
View article: Limited cellular uptake of liposomes: Might thiolated phospholipids hold the key?
Limited cellular uptake of liposomes: Might thiolated phospholipids hold the key? Open
Surface thiolation represents a promising approach to enhance cellular uptake of liposomes.
View article: Mucoadhesive polymers: Design of S-protected thiolated cyclodextrin-based hydrogels
Mucoadhesive polymers: Design of S-protected thiolated cyclodextrin-based hydrogels Open
Because of their comparatively high mucoadhesive and release-controlling properties, S-protected thiolated β-CD-based hydrogels might be promising systems for mucosal drug delivery.
View article: The power of sulfhydryl groups: Thiolated lipid-based nanoparticles enhance cellular uptake of nucleic acids
The power of sulfhydryl groups: Thiolated lipid-based nanoparticles enhance cellular uptake of nucleic acids Open
Surface thiolation of LNPs represents a promising tool for enhancing intracellular nucleic acid delivery of LNPs.
View article: Fluorescent hydrophobic ion pairs: A powerful tool to investigate cellular uptake of hydrophobic drug complexes via lipid-based nanocarriers
Fluorescent hydrophobic ion pairs: A powerful tool to investigate cellular uptake of hydrophobic drug complexes via lipid-based nanocarriers Open
HIP-formation increased lipophilicity of the hydrophilic model drugs. NE exhibited a size between 80 and 150 nm and were not toxic in concentrations up to 0.1 % but showed high haemolytic properties. Cellular uptake of propidium, azure A a…
View article: Self‐Emulsifying Drug Delivery Systems (SEDDS) Containing Reverse Micelles: Advanced Oral Formulations for Therapeutic Peptides
Self‐Emulsifying Drug Delivery Systems (SEDDS) Containing Reverse Micelles: Advanced Oral Formulations for Therapeutic Peptides Open
Alternative methods to hydrophobic ion pairing for the formation of lipophilic complexes of peptide drugs to incorporate them in lipid‐based nanocarriers such as self‐emulsifying drug delivery systems (SEDDS) for oral administration are hi…
View article: Oral drug delivery: Influence of mucus on cellular interactions and uptake of lipid-based nanocarriers in Caco-2 cells
Oral drug delivery: Influence of mucus on cellular interactions and uptake of lipid-based nanocarriers in Caco-2 cells Open
This study aimed to investigate the impact of the mucus gel barrier on intestinal mucosal uptake of lipid-based nanocarriers (NCs). Zwitterionic- (ZW), polyglycerol- (PG) and polyethylene glycol- (PEG) surfactant-based o/w nanoemulsions we…
View article: PEG vs. zwitterions: How these surface decorations determine cellular uptake of lipid-based nanocarriers
PEG vs. zwitterions: How these surface decorations determine cellular uptake of lipid-based nanocarriers Open
The replacement of PEG surfactants with zwitterionic surfactants is a promising approach to overcome the drawbacks of conventional PEGylated lipid-based NCs regarding intracellular drug delivery.
View article: Development and validation of a neurotoxicological test battery for neurotoxicity risk assessment
Development and validation of a neurotoxicological test battery for neurotoxicity risk assessment Open
The present study was conducted as part of the research project "Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany”, funded by the Federal Ministry of Education and Resea…