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View article: Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity
Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity Open
Caffeine is the most widely consumed psychoactive substance globally, yet its peripheral physiological effects remain incompletely understood. Leveraging comprehensive data from 13,091 blood donors in the REDS RBC-Omics study, we identify …
View article: Early adipose tissue wasting in a preclinical model of human lung cancer cachexia
Early adipose tissue wasting in a preclinical model of human lung cancer cachexia Open
View article: Increased Exercise Tolerance in G6PD African Variant Mice Driven by Metabolic Adaptations and Erythrophagocytosis
Increased Exercise Tolerance in G6PD African Variant Mice Driven by Metabolic Adaptations and Erythrophagocytosis Open
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymatic disorder, affects over 500 million people worldwide and is often linked to exercise intolerance due to oxidative stress, but its true impact on physical perform…
View article: Choice of lipid supplementation for <i>in vitro</i> erythroid cell culture impacts reticulocyte yield and characteristics
Choice of lipid supplementation for <i>in vitro</i> erythroid cell culture impacts reticulocyte yield and characteristics Open
Lipids, particularly cholesterol, are critical components of red blood cell (RBC) membranes, influencing protein function, cell stability, and deformability. Reticulocytes (young RBC) derived from in vitro erythroid cultures have been repo…
View article: Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity
Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity Open
Caffeine is the most widely consumed psychoactive substance globally, yet its peripheral physiological effects remain incompletely understood. Leveraging comprehensive data from 13,091 blood donors in the REDS RBC-Omics study, we identify …
View article: Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2
Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2 Open
Summary While the development of venetoclax with azacitidine (ven/aza) has improved AML therapy, drug resistance remains a major challenge. Notably, primary ven/aza-resistant AML are frequently reliant on MCL1, however, the underlying mech…
View article: Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells
Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells Open
Ultra-endurance exercise places extreme physiological demands on oxygen transport, yet its impact on red blood cells (RBCs) remains underexplored. We conducted a multi-omics analysis of plasma and RBCs from endurance athletes before and af…
View article: Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance
Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance Open
Although refrigerated storage slows the metabolism of volunteer donor RBCs, which is essential in transfusion medicine, cellular aging still occurs throughout this in vitro process. Storage-induced microerythrocytes (SMEs) are morphologica…
View article: Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools
Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools Open
Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage—critical for transfusions. To explore genetic influences on RBC resilience, we profiled proteins, metabolites, …
View article: Increased exercise tolerance in humanized G6PD-deficient mice
Increased exercise tolerance in humanized G6PD-deficient mice Open
Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects 500 million people globally, affecting red blood cell (RBC) antioxidant pathways and increasing susceptibility to hemolysis under oxidative stress. Despite the systemic generation…
View article: Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis Open
Senescent neural progenitor cells have been identified in brain lesions of people with progressive multiple sclerosis (PMS). However, their role in disease pathobiology and contribution to the lesion environment remains unclear. By establi…
View article: Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia
Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia Open
Summary Cancer cachexia (CC), a syndrome of skeletal muscle and adipose wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC, which may relate to discordance between pre-clinical mod…
View article: <b>Selective Reduction of Ca</b><sup><strong>2+</strong></sup><b>-Independent Phospholipase A</b><sub><strong>2</strong></sub><b>b</b><b> (iPLA</b><sub><strong>2</strong></sub><b>b</b><b>)-Derived Lipid Signaling from Macrophages Mitigates Type 1 Diabetes Development</b>
<b>Selective Reduction of Ca</b><sup><strong>2+</strong></sup><b>-Independent Phospholipase A</b><sub><strong>2</strong></sub><b>b</b><b> (iPLA</b><sub><strong>2</strong></sub><b>b</b><b>)-Derived Lipid Signaling from Macrophages Mitigates Type 1 Diabetes Development</b> Open
AbstractType 1 diabetes (T1D) is a consequence of autoimmune destruction of b-cells and macrophages (MF) have a central role in initiating processes that lead to b-cell demise. We reported that Ca2+-independent phospholip…
View article: Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance
Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance Open
Although refrigerated storage slows the metabolism of volunteer donor RBCs, cellular aging still occurs throughout this in vitro process, which is essential in transfusion medicine. Storage-induced microerythrocytes (SMEs) are morphologica…
View article: Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Table 2
View article: Supplementary Figure legend from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Figure legend from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Figure legend
View article: Supplementary Fig 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 3
View article: Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 2
View article: Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
The genetic landscape of cancer cells can lead to specific metabolic dependencies for tumor growth. Dietary interventions represent an attractive strategy to restrict the availability of key nutrients to tumors. In this study, we identifie…
View article: Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 6
View article: Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 6 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 6
View article: Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 4
View article: Supplementary Fig 5 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 5 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 5
View article: Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 4 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 4
View article: Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 1
View article: Supplementary Table 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Table 3 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Table 3
View article: Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Table 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Table 2
View article: Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Data from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
The genetic landscape of cancer cells can lead to specific metabolic dependencies for tumor growth. Dietary interventions represent an attractive strategy to restrict the availability of key nutrients to tumors. In this study, we identifie…
View article: Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 2 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 2
View article: Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis
Supplementary Fig 1 from A Multimodal Drug–Diet–Immunotherapy Combination Restrains Melanoma Progression and Metastasis Open
Supplementary Fig 1