Daniel T. Cannon
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View article: Imposed expiratory resistance, dynamic hyperinflation and locomotor power and fatigue
Imposed expiratory resistance, dynamic hyperinflation and locomotor power and fatigue Open
Expiratory flow limitation results in dynamic hyperinflation, dyspnoea and premature exercise intolerance. We aimed to measure whether expiratory resistance reduces locomotor power via limiting maximal voluntary motor activity, exacerbatin…
View article: Heat stress and the velocity–duration relationship in amateur runners
Heat stress and the velocity–duration relationship in amateur runners Open
Tolerance to high‐intensity constant power exercise can be characterized by the hyperbolic power‐duration (or velocity–duration) relationship. The hyperbola is defined by the asymptote (critical power or velocity) and the curvature constan…
View article: IL‐33/ST2 receptor‐dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice
IL‐33/ST2 receptor‐dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice Open
Pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality. PAH is characterized by pulmonary artery remodeling, elevated right ventricular pressure (RVP) and, ultimately, cardiac failure. Pulmonary endoth…
View article: Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension
Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension Open
Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature that leads to right ventricular failure. Skeletal muscle maladaptations limit physical activity and may contribute to disease progression. The role…
View article: Pulmonary function with expiratory resistive loading in healthy volunteers
Pulmonary function with expiratory resistive loading in healthy volunteers Open
Expiratory flow limitation is a key characteristic in obstructive pulmonary diseases. To study abnormal lung mechanics isolated from heterogeneities of obstructive disease, we measured pulmonary function in healthy adults with expiratory l…
View article: Safety proposals for freediving time limits should consider the metabolic-rate dependence of oxygen stores depletion
Safety proposals for freediving time limits should consider the metabolic-rate dependence of oxygen stores depletion Open
(Sadler C, Brett K, Heerboth A, Swisher AR, Mehregani N, Touriel R, Cannon DT. Safety proposals for freediving time limits should consider the metabolic-rate dependence of oxygen stores depletion. Diving and Hyperbaric Medicine. 2020 Decem…
View article: Deviated nasal septum hinders intranasal sprays: A computer simulation study
Deviated nasal septum hinders intranasal sprays: A computer simulation study Open
This study investigates how deviated nasal septum affects the quantity and distribution of spray particles, and examines the effects of inspiratory airflow and head position on particle transport.
View article: Computed intranasal spray penetration: comparisons before and after nasal surgery
Computed intranasal spray penetration: comparisons before and after nasal surgery Open
Quantitative methods for comparing intranasal drug delivery efficiencies pre- and postoperatively have not been fully utilized. The objective of this study is to use computational fluid dynamics techniques to evaluate aqueous nasal spray p…
View article: Skeletal myofiber VEGF deficiency leads to mitochondrial, structural, and contractile alterations in mouse diaphragm
Skeletal myofiber VEGF deficiency leads to mitochondrial, structural, and contractile alterations in mouse diaphragm Open
Diaphragm dysfunction accompanies cardiopulmonary disease and impaired oxygen delivery. Vascular endothelial growth factor (VEGF) regulates oxygen delivery through angiogenesis, capillary maintenance, and contraction-induced perfusion. We …
View article: Dissociating external power from intramuscular exercise intensity during intermittent bilateral knee‐extension in humans
Dissociating external power from intramuscular exercise intensity during intermittent bilateral knee‐extension in humans Open
Key points Continuous high‐intensity constant‐power exercise is unsustainable, with maximal oxygen uptake ( ) and the limit of tolerance attained after only a few minutes. Performing the same power intermittently reduces the O 2 cost of ex…
View article: Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD
Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD Open
Muscle fatigue (a reduced power for a given activation) is common following exercise in chronic obstructive pulmonary disease (COPD). Whether muscle fatigue, and reduced maximal voluntary locomotor power, are sufficient to limit whole body…
View article: Impaired Lung Mitochondrial Respiration Following Perinatal Nicotine Exposure in Rats
Impaired Lung Mitochondrial Respiration Following Perinatal Nicotine Exposure in Rats Open
View article: No reserve in isokinetic cycling power at intolerance during ramp incremental exercise in endurance-trained men
No reserve in isokinetic cycling power at intolerance during ramp incremental exercise in endurance-trained men Open
During whole body exercise in health, maximal oxygen uptake (V̇o 2max ) is typically attained at or immediately before the limit of tolerance (LoT). At the V̇o 2max and LoT of incremental exercise, a fundamental, but unresolved, question is …