Daniel T. Gray
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View article: Dynamic changes in mitochondria support phenotypic flexibility of microglia
Dynamic changes in mitochondria support phenotypic flexibility of microglia Open
Microglial capacity to adapt to tissue needs is a hallmark feature of these cells. New studies show that mitochondria critically regulate the phenotypic adaptability of macrophages. To determine whether these organelles play similar roles …
View article: Midbrain extracellular matrix and microglia are associated with cognition in aging mice
Midbrain extracellular matrix and microglia are associated with cognition in aging mice Open
Synapse dysfunction is tightly linked to cognitive changes during aging. Emerging evidence suggests that microglia and the extracellular matrix (ECM) can potently regulate synapse integrity and plasticity. Yet the brain ECM, and its relati…
View article: Extracellular matrix remodeling during aging aligns with synapse, microglia, and cognitive status
Extracellular matrix remodeling during aging aligns with synapse, microglia, and cognitive status Open
Synapse dysfunction is tightly linked to cognitive changes during aging, but underlying mechanisms driving dysfunction are minimally understood. The extracellular matrix (ECM) can potently regulate synapse integrity and plasticity. Yet the…
View article: A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments
A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments Open
Locus coeruleus (LC) neurons send their noradrenergic axons across multiple brain regions, including neocortex, subcortical regions, and spinal cord. Many aspects of cognition are known to be dependent on the noradrenergic system, and it h…
View article: Dynamic changes in mitochondria support phenotypic flexibility of microglia
Dynamic changes in mitochondria support phenotypic flexibility of microglia Open
Microglial capacity to adapt to tissue needs is a hallmark feature of these cells. New studies show that mitochondria critically regulate the phenotypic adaptability of macrophages. To determine whether these organelles play similar roles …
View article: Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques
Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques Open
Synapse loss and altered plasticity are significant contributors to memory loss in aged individuals. Microglia, the innate immune cells of the brain, play critical roles in maintaining synapse function, including through a recently identif…
View article: Aged Rats Exhibit Altered Behavior-Induced Oscillatory Activity, Place Cell Firing Rates, and Spatial Information Content in the CA1 Region of the Hippocampus
Aged Rats Exhibit Altered Behavior-Induced Oscillatory Activity, Place Cell Firing Rates, and Spatial Information Content in the CA1 Region of the Hippocampus Open
Hippocampal gamma and theta oscillations are associated with mnemonic and navigational processes and adapt to changes in the behavioral state of an animal to optimize spatial information processing. It has been shown that locomotor activit…
View article: Microglia Drive Pockets of Neuroinflammation in Middle Age
Microglia Drive Pockets of Neuroinflammation in Middle Age Open
During aging, microglia produce inflammatory factors, show reduced tissue surveillance, altered interactions with synapses, and prolonged responses to CNS insults, positioning these cells to have profound impact on the function of nearby n…
View article: AMPA Receptors Exist in Tunable Mobile and Immobile Synaptic Fractions<i>In Vivo</i>
AMPA Receptors Exist in Tunable Mobile and Immobile Synaptic Fractions<i>In Vivo</i> Open
Highlighted Research Paper: AMPA Receptors Exist in Tunable Mobile and Immobile Synaptic Fractions In Vivo , by Haiwen Chen, Richard H. Roth, Elena Lopez-Ortega, Han L. Tan, and Richard L. Huganir.
View article: Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques
Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques Open
Deficits in auditory and visual processing are commonly encountered by older individuals. In addition to the relatively well described age-associated pathologies that reduce sensory processing at the level of the cochlea and eye, multiple …
View article: Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function
Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function Open
The use of animal models in brain aging research has led to numerous fundamental insights into the neurobiological processes that underlie changes in brain function associated with normative aging. Macaque monkeys have become the predomina…
View article: Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques
Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques Open
Deficits in auditory function and cognition are hallmarks of normative aging. Recent evidence suggests that hearing-impaired individuals have greater risks of developing cognitive impairment and dementia compared to people with intact audi…
View article: An Alternative to Dye-Based Approaches to Remove Background Autofluorescence From Primate Brain Tissue
An Alternative to Dye-Based Approaches to Remove Background Autofluorescence From Primate Brain Tissue Open
Brain tissue contains autofluorescing elements that potentially impede accurate identification of neurons when visualized with fluorescent microscopy. Age-related accumulation of molecules with autofluorescent properties, such as lipofusci…
View article: Seizure-Induced Arc mRNA Expression Thresholds in Rat Hippocampus and Perirhinal Cortex
Seizure-Induced Arc mRNA Expression Thresholds in Rat Hippocampus and Perirhinal Cortex Open
Immediate-early genes (IEGs) are rapidly and transiently induced following excitatory neuronal activity including maximal electroconvulsive shock treatment (ECT). The rapid RNA response can be blocked by the sodium channel antagonist tetro…
View article: A separable two-dimensional random field model of binary response data from multi-day behavioral experiments
A separable two-dimensional random field model of binary response data from multi-day behavioral experiments Open
Applied to binary response data from groups of individuals performing multi-day behavioral experiments, the model discriminates between-group differences and identifies subgroups.
View article: Tract-Specific White Matter Correlates of Age-Related Reward Devaluation Deficits in Macaque Monkeys
Tract-Specific White Matter Correlates of Age-Related Reward Devaluation Deficits in Macaque Monkeys Open
These results suggest that the condition of the white matter connecting the amygdala and OFC may impact reward devaluation behaviors. Furthermore, the observation that FA indices from the UF and AF differentially relate to reward devaluati…
View article: Age Is Associated with Reduced Sharp-Wave Ripple Frequency and Altered Patterns of Neuronal Variability
Age Is Associated with Reduced Sharp-Wave Ripple Frequency and Altered Patterns of Neuronal Variability Open
Spatial and episodic memory performance declines with age, and the neural basis for this decline is not well understood. Sharp-wave ripples are brief (∼70 ms) high-frequency oscillatory events generated in the hippocampus and are associate…