Daniel T. Meier
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View article: Blood Characteristics of Adults With Type 2 Diabetes and Response of Their Peripheral Blood Mononuclear Cells to Inhibitors of the NLRP3 Inflammasome and Caspase-1
Blood Characteristics of Adults With Type 2 Diabetes and Response of Their Peripheral Blood Mononuclear Cells to Inhibitors of the NLRP3 Inflammasome and Caspase-1 Open
Inhibition of inflammasome activation has emerged as a promising therapeutic strategy for management of diabetes-related complications.
View article: Reward Maximization for Pure Exploration: Minimax Optimal Good Arm Identification for Nonparametric Multi-Armed Bandits
Reward Maximization for Pure Exploration: Minimax Optimal Good Arm Identification for Nonparametric Multi-Armed Bandits Open
In multi-armed bandits, the tasks of reward maximization and pure exploration are often at odds with each other. The former focuses on exploiting arms with the highest means, while the latter may require constant exploration across all arm…
View article: Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune Cells Induces Sepsis Hypersensitivity
Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune Cells Induces Sepsis Hypersensitivity Open
Prohormone convertase 1/3 (PC1/3) is an endopeptidase required for the processing of neuropeptide and endocrine peptide precursors; it is expressed in neuroendocrine tissues as well as in immune cells. In response to endotoxemia, global PC…
View article: IL-1β promotes adipogenesis by directly targeting adipocyte precursors
IL-1β promotes adipogenesis by directly targeting adipocyte precursors Open
Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage and show that adipocyte-specific deletion of IL-1 receptor 1 (IL1R1…
View article: Similar metabolic pathways are affected in both Congenital Myasthenic Syndrome-22 and Prader-Willi Syndrome
Similar metabolic pathways are affected in both Congenital Myasthenic Syndrome-22 and Prader-Willi Syndrome Open
Loss of prolyl endopeptidase-like ( PREPL ) encoding a serine hydrolase with (thio)esterase activity leads to the recessive metabolic disorder Congenital Myasthenic Syndrome-22 (CMS22). It is characterized by severe neonatal hypotonia, fee…
View article: Protocol for isolation and spectral flow cytometry analysis of immune cells from the murine exocrine and endocrine pancreas
Protocol for isolation and spectral flow cytometry analysis of immune cells from the murine exocrine and endocrine pancreas Open
Diabetes mellitus is a disease of the hormone-secreting endocrine pancreas. However, increasing evidence suggests that the exocrine pancreas is also involved in the pathogenesis of diabetes. In this protocol, we describe how to harvest bot…
View article: Cystine/Glutamate antiporter system xc- deficiency impairs macrophage glutathione metabolism and cytokine production
Cystine/Glutamate antiporter system xc- deficiency impairs macrophage glutathione metabolism and cytokine production Open
System x c - , encoded by Slc7a11 , is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-f…
View article: Cystine/glutamate antiporter System xc- deficiency impairs insulin secretion in mice
Cystine/glutamate antiporter System xc- deficiency impairs insulin secretion in mice Open
Aims/hypothesis Glutamate-induced cytotoxicity (excitotoxicity) has been detected in pancreatic beta cells. The cystine/glutamate antiporter System x c - exports glutamate to the extracellular space and is therefore implicated as driving e…
View article: Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production.
Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production. Open
Raw Data for Publication "Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production."
View article: Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production.
Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production. Open
Raw Data for Publication "Cystine/glutamate antiporter system Xc- deficiency impairs macrophage glutathione metabolism and cytokine production."
View article: Cystine/glutamate antiporter system Xc<sup>-</sup>deficiency impairs insulin secretion
Cystine/glutamate antiporter system Xc<sup>-</sup>deficiency impairs insulin secretion Open
System Xc - , encoded by Slc7a11 , is an antiporter that exports glutamate and imports cystine. Cystine is used for protein synthesis and incorporation in thiol peptides such as glutathione, which function as cofactors for reactive oxygen …
View article: The cephalic phase of insulin release is modulated by IL-1β
The cephalic phase of insulin release is modulated by IL-1β Open
The initial cephalic phase of insulin secretion is mediated through the vagus nerve and is not due to glycemic stimulation of pancreatic β cells. Recently, IL-1β was shown to stimulate postprandial insulin secretion. Here, we describe that…
View article: Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity
Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity Open
The obesity epidemic continues to worsen worldwide. However, the mechanisms initiating glucose dysregulation in obesity remain poorly understood. We assessed the role that colonic macrophage subpopulations play in glucose homeostasis in mi…
View article: Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus
Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus Open
Type 2 diabetes mellitus (T2DM) is a chronic progressive disease characterized by insulin resistance and insufficient insulin secretion to maintain normoglycemia. The majority of T2DM patients bear amyloid deposits mainly composed of islet…
View article: Data of Figure 5 from "Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes"
Data of Figure 5 from "Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes" Open
Data of Figure 5 from “Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes” Dataset (doi: 10.1038/s41598-020-59701-0) contains the original publication as PDF-format (10.1038_s41598-020-59701-0). Correspondi…
View article: Data of Figure 5 from "Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes"
Data of Figure 5 from "Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes" Open
Data of Figure 5 from “Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes” Dataset (doi: 10.1038/s41598-020-59701-0) contains the original publication as PDF-format (10.1038_s41598-020-59701-0). Correspondi…
View article: Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes
Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes Open
Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to inves…
View article: Air pollution mediates diabetes by disrupting gut innate mucosal immunity
Air pollution mediates diabetes by disrupting gut innate mucosal immunity Open
Air pollution has emerged as an unexpected risk factor for diabetes 1–6 . The mechanisms linking air pollution and diabetes remain, however, unknown. It has been postulated that lung exposure mediates diabetes via systemic inflammation and…
View article: Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease
Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease Open
The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action and …
View article: Islet inflammation in type 2 diabetes
Islet inflammation in type 2 diabetes Open
Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytok…