Paul D. Thompson
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View article: Do faster runners live longer? An analysis among 141,507 recreational runners
Do faster runners live longer? An analysis among 141,507 recreational runners Open
Background The dose-response relationship between physical activity characteristics, cardiopulmonary fitness and mortality are well-established, but the relationship between running characteristics and long-term outcomes in recreational at…
View article: Arterial stiffness and coronary atherosclerosis in middle-aged and older athletes: findings from the MARC and MARC-2 studies
Arterial stiffness and coronary atherosclerosis in middle-aged and older athletes: findings from the MARC and MARC-2 studies Open
Background Studies have reported an increased arterial stiffness and prevalence of coronary artery calcification (CAC) in veteran athletes, suggesting an association between these deleterious cardiovascular adaptations. Purpose We determin…
View article: Muscle Strength and Size Relationships with Unilateral Progressive Resistance Training
Muscle Strength and Size Relationships with Unilateral Progressive Resistance Training Open
Purpose This study defines correlative and causal relationships between muscle strength and size before and after unilateral resistance training (RT) in a large cohort of healthy adults, focusing on sex differences within these relationshi…
View article: All-cause mortality risks among participants in mass-participation sporting events
All-cause mortality risks among participants in mass-participation sporting events Open
Objectives Exercise transiently increases the risk for sudden death, whereas long-term exercise promotes longevity. This study assessed acute and intermediate-term mortality risks of participants in mass-participation sporting events. Meth…
View article: Associations of Lifelong Exercise Characteristics With Valvular Function and Aortic Diameters in Patients With a Bicuspid Aortic Valve
Associations of Lifelong Exercise Characteristics With Valvular Function and Aortic Diameters in Patients With a Bicuspid Aortic Valve Open
Background The potential impact of exercise on valvular function and aortic diameters in patients with a bicuspid aortic valve remains unclear. Therefore, we assessed the association between lifelong exercise characteristics, valvular dysf…
View article: Associations of Lifelong Exercise Characteristics with Valvular Function and Aortic Diameters in Subjects with a Bicuspid Aortic Valve
Associations of Lifelong Exercise Characteristics with Valvular Function and Aortic Diameters in Subjects with a Bicuspid Aortic Valve Open
Background Whether exercise-induced hemodynamic stress accelerates the development of valvular dysfunction and aortic dilatation in subjects with a bicuspid aortic valve (BAV) is unclear. Purpose To examine the association between lifelong…
View article: Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study
Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study Open
Background: Physical activity and exercise training are associated with a lower risk for coronary events. However, cross-sectional studies in middle-aged and older male athletes revealed increased coronary artery calcification (CAC) and at…
View article: Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands
Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands Open
Background Moderate to vigorous physical activity (MVPA) is strongly associated with risk reductions of noncommunicable diseases and mortality. Cardiovascular health status may influence the benefits of MVPA. We compare the association bet…
View article: Use of Lipid-Lowering Therapies Over 2 Years in GOULD, a Registry of Patients With Atherosclerotic Cardiovascular Disease in the US
Use of Lipid-Lowering Therapies Over 2 Years in GOULD, a Registry of Patients With Atherosclerotic Cardiovascular Disease in the US Open
Of patients with ASCVD, most with suboptimal LDL-C levels at baseline, only 17.1% had LLT intensification after 2 years, and two-thirds remained at an LDL-C level greater than 70 mg/dL. Further intensive efforts are needed to achieve optim…
View article: Rationale for the use of metformin and exercise to counteract statin‐associated side effects
Rationale for the use of metformin and exercise to counteract statin‐associated side effects Open
This combination appears attractive both from a clinical and an economical viewpoint, since all three therapies are highly cost-effective and their combination could result in diabetes and cardiovascular disease prevention.
View article: Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113
Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113 Open
The authors wish to make the following corrections to this paper [...]
View article: Association of Cardiac Rehabilitation With All-Cause Mortality Among Patients With Cardiovascular Disease in the Netherlands
Association of Cardiac Rehabilitation With All-Cause Mortality Among Patients With Cardiovascular Disease in the Netherlands Open
In this cohort study, CR participation was associated with a 32% risk reduction in all-cause mortality, and this benefit was independent of sex, age, socioeconomic status, and comorbidity. These findings reinforce the importance of CR part…
View article: 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease
2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease Open
A correction has been published:
\nEuropean Heart Journal, Volume 42, Issue 5, 1 February 2021, Pages 548–549, https://doi.org/10.1093/eurheartj/ehaa835
View article: Evolocumab in HIV-Infected Patients With Dyslipidemia
Evolocumab in HIV-Infected Patients With Dyslipidemia Open
Evolocumab was safe and significantly reduced lipid levels in dyslipidemic PLHIV on maximally-tolerated statin therapy. Evolocumab is an effective therapy for lowering atherogenic lipoproteins in PLHIV with high cardiovascular risk. (Safet…
View article: Efficacy and safety of alirocumab in statin-intolerant patients over 3 years: open-label treatment period of the ODYSSEY ALTERNATIVE trial
Efficacy and safety of alirocumab in statin-intolerant patients over 3 years: open-label treatment period of the ODYSSEY ALTERNATIVE trial Open
In this population of statin-intolerant patients, alirocumab was well tolerated and produced durable LDL-C reductions over 3 years.
View article: Exercise-Induced Cardiac Troponin I Increase and Incident Mortality and Cardiovascular Events
Exercise-Induced Cardiac Troponin I Increase and Incident Mortality and Cardiovascular Events Open
Background: Blood concentrations of cardiac troponin above the 99 th percentile are a key criterion for the diagnosis of acute myocardial injury and infarction. Troponin concentrations, even below the 99 th percentile, predict adverse outc…
View article: Association between Lifelong Physical Activity and Disease Characteristics in HCM
Association between Lifelong Physical Activity and Disease Characteristics in HCM Open
Purpose Hypertrophic cardiomyopathy (HCM) is characterized by inappropriate left ventricular (LV) wall thickness. Adaptations to exercise can occasionally mimic certain HCM characteristics. However, it is unclear whether physical activity …
View article: A genetic variant in <i><scp>IL</scp>‐15R</i>α correlates with physical activity among European–American adults
A genetic variant in <i><span>IL</span>‐15R</i>α correlates with physical activity among European–American adults Open
Background Interleukin‐15 ( IL ‐15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha‐receptor ( IL ‐15R α 1775 A>C, rs2228059) partially modulates the muscle strength and size …
View article: Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension
Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension Open
In previous studies, we found an endothelial nitric oxide synthase gene ( NOS 3 ) variant rs2070744 associated with the ambulatory blood pressure ( BP ) response following bouts of moderate and vigorous intensity acute exercise, termed pos…
View article: Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism
Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism Open
Statin use attenuated substrate use during maximal exercise performance, induced muscle fatigue during repeated muscle contractions, and decreased muscle mitochondrial oxidative capacity. This suggests disturbances in mitochondrial oxidati…
View article: The angiotensin-converting enzyme insertion/deletion polymorphism rs4340 associates with habitual physical activity among European American adults
The angiotensin-converting enzyme insertion/deletion polymorphism rs4340 associates with habitual physical activity among European American adults Open
BMI interacted with ACE DD such that OW walked ~8.2 km/week less than NW, potentially equating to a body weight differential of ~3.5 kg annually.
View article: Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes
Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes Open
Background: Higher levels of physical activity are associated with a lower risk of cardiovascular events. Nevertheless, there is debate on the dose-response relationship of exercise and cardiovascular disease outcomes and whether high volu…
View article: Association Between Statin Use and Prevalence of Exercise-Related Injuries: A Cross-Sectional Survey of Amateur Runners in the Netherlands
Association Between Statin Use and Prevalence of Exercise-Related Injuries: A Cross-Sectional Survey of Amateur Runners in the Netherlands Open
We did not find an association between statin use and the prevalence of exercise-related injuries or tendon-, ligament-, and muscle-related injuries. Runners receiving statins should continue normal physical activity without concern for in…