Daniel Vuong
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View article: Heterologous expression of an <i>in planta</i> -upregulated gene cluster in the wheat pathogen <i>Parastagonospora nodorum</i> establishes the biosynthesis of methylene-bridged depsides
Heterologous expression of an <i>in planta</i> -upregulated gene cluster in the wheat pathogen <i>Parastagonospora nodorum</i> establishes the biosynthesis of methylene-bridged depsides Open
Discovery of nodorasides A and B reveals that rare methylene-bridged depsides arise via an enzyme-initiated ortho -quinone methide intermediate, providing the first biosynthetic insight into this unusual crosslinking.
View article: Geministatins: new depside antibiotics from the fungus Austroacremonium gemini
Geministatins: new depside antibiotics from the fungus Austroacremonium gemini Open
Two new depside antibiotics, geministatins A ( 1 ) and B ( 2 ), were isolated from the fungus Austroacremonium gemini MST-FP2131 ( Sordariomycetes , Ascomycota ), which was recovered from rotting wood in the wet tropics of northern Austral…
View article: The aquastatin biosynthetic gene cluster encodes a versatile polyketide synthase capable of synthesising heteromeric depsides with diverse alkyl side chains
The aquastatin biosynthetic gene cluster encodes a versatile polyketide synthase capable of synthesising heteromeric depsides with diverse alkyl side chains Open
The aqu BGC from Austroacremonium gemini encodes a versatile polyketide synthase capable of synthesising heteromeric depsides with diverse alkyl side chains.
View article: Discovery and heterologous biosynthesis of glycosylated polyketide luteodienoside A reveals unprecedented glucinol-mediated product offloading by a fungal carnitine <i>O</i>-acyltransferase domain
Discovery and heterologous biosynthesis of glycosylated polyketide luteodienoside A reveals unprecedented glucinol-mediated product offloading by a fungal carnitine <i>O</i>-acyltransferase domain Open
Luteodienoside A – a glycosylated polyketide produced by the Australian fungus Aspergillus luteorubrus is biosynthesised by a polyketide synthase with a carnitine O -acyltransferase domain capable of adding glucinol to the polyketide produ…
View article: Type-I Hemins and Free Porphyrins from a Western Australian Sponge Isabela sp.
Type-I Hemins and Free Porphyrins from a Western Australian Sponge Isabela sp. Open
Two novel free porphyrins, isabellins A and B, as well as the known compounds corallistin D and deuteroporphyrin IX were isolated from a marine sponge Isabela sp. LC-MS analysis of the crude extract revealed that the natural products were …
View article: The composition and natural variation of the skin microbiota in healthy Australian cattle
The composition and natural variation of the skin microbiota in healthy Australian cattle Open
Background Skin diseases in cattle pose significant animal welfare issues and financial burdens. Microbial communities inhabiting the skin have essential roles in maintaining host health. Microbiota manipulation can be an efficient strateg…
View article: Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki–Miyaura cross-couplings
Synthesis of 4-phenylthieno[2,3-c]quinolines via Suzuki–Miyaura cross-couplings Open
A small library of previously unreported 4-phenylthieno[3,2-c]quinolines was prepared from a simple thiophene substrate via a modular synthetic strategy that exploited successive palladium-catalyzed crosscoupling reactions.These heterocycl…
View article: Expanding antibiotic chemical space through precursor-directed biosynthesis
Expanding antibiotic chemical space through precursor-directed biosynthesis Open
The rapid emergence of multidrug-resistant microorganisms demands continuous development of new antibiotics with novel modes of action. However, very few candidates are currently in the pipeline. The present study addresses this challenge …
View article: Isolation and semi-synthesis of enterocin analogues as novel antibiotics
Isolation and semi-synthesis of enterocin analogues as novel antibiotics Open
Enterocin, a uniquely-structured polyketide, was first isolated in 1976 from two soil Streptomyces with reported broad-spectrum bacteriostatic activity. In this thesis, the chemical and biological properties of enterocin were re-investigat…
View article: Genome Mining of <i>Aspergillus hancockii</i> Unearths Cryptic Polyketide Hancockinone A Featuring a Prenylated 6/6/6/5 Carbocyclic Skeleton
Genome Mining of <i>Aspergillus hancockii</i> Unearths Cryptic Polyketide Hancockinone A Featuring a Prenylated 6/6/6/5 Carbocyclic Skeleton Open
Activation of a cryptic polyketide synthase gene cluster hkn from Aspergillus hancockii via overexpression of the gene-cluster-specific transcription factor HknR led to the discovery of a novel polycyclic metabolite, which we named hancock…
View article: Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii
Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii Open
Chemical exploration of the recently described Australian fungus, Aspergillus burnettii, uncovered a new metabolite, burnettiene A. Here, we characterise the structure of burnettiene A as a polyene-decalin polyketide. Bioinformatic analysi…
View article: Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii
Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii Open
Chemical exploration of the recently described Australian fungus, Aspergillus burnettii, uncovered a new metabolite, burnettiene A. Here, we characterise the structure of burnettiene A as a polyene-decalin polyketide. Bioinformatic analysi…
View article: Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne
Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne Open
The ClpX ATPase is critical for resistance to cell envelope targeting antibiotics in Bacillus anthracis , however, it is unclear whether this is due to its function as an independent chaperone or as part of the ClpXP protease. In this stud…
View article: Testing the effectiveness of community-engaged citizen science to promote physical activity, foster healthier neighborhood environments, and advance health equity in vulnerable communities: The Steps for Change randomized controlled trial design and methods
Testing the effectiveness of community-engaged citizen science to promote physical activity, foster healthier neighborhood environments, and advance health equity in vulnerable communities: The Steps for Change randomized controlled trial design and methods Open
While low-income midlife and older adults are disproportionately affected by non-communicable diseases that can be alleviated by regular physical activity, few physical activity programs have been developed specifically with their needs in…
View article: Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections
Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections Open
Our recent focus on the “lost antibiotic” unguinol and related nidulin-family fungal natural products identified two semisynthetic derivatives, benzguinols A and B, with unexpected in vitro activity against Staphylococcus aureus isolates e…
View article: Chlorinated metabolites from <i>Streptomyces</i> sp. highlight the role of biosynthetic mosaics and superclusters in the evolution of chemical diversity
Chlorinated metabolites from <i>Streptomyces</i> sp. highlight the role of biosynthetic mosaics and superclusters in the evolution of chemical diversity Open
Biosynthetic mosaics and superclusters provide rare insights into the evolution of microbial chemical diversity.
View article: Hancockiamides: phenylpropanoid piperazines from <i>Aspergillus hancockii</i> are biosynthesised by a versatile dual single-module NRPS pathway
Hancockiamides: phenylpropanoid piperazines from <i>Aspergillus hancockii</i> are biosynthesised by a versatile dual single-module NRPS pathway Open
The hancockiamides are an unusual new family of N-cinnamoylated piperazines from the Australian soil fungus Aspergillus hancockii, originating from mixed nonribosomal peptide and phenylpropanoid pathways.
View article: Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in<i>Giardia</i>
Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in<i>Giardia</i> Open
Methylation is a common posttranslational modification of arginine and lysine in eukaryotic proteins. Methylproteomes are best characterized for higher eukaryotes, where they are functionally expanded and evolved complex regulation. Howeve…
View article: Biosynthesis of a New Benzazepine Alkaloid Nanangelenin A from <i>Aspergillus nanangensis</i> Involves an Unusual <scp>l</scp>-Kynurenine-Incorporating NRPS Catalyzing Regioselective Lactamization
Biosynthesis of a New Benzazepine Alkaloid Nanangelenin A from <i>Aspergillus nanangensis</i> Involves an Unusual <span>l</span>-Kynurenine-Incorporating NRPS Catalyzing Regioselective Lactamization Open
1-Benzazepine is a pharmaceutically important scaffold but is rare among natural products. Nanangelenin A (1), containing an unprecedented 3,4-dihydro-1-benzazepine-2,5-dione-N-prenyl-N-acetoxy-anthranilamide scaffold, was isolated from a …
View article: Production of novel pladienolide analogues through native expression of a pathway-specific activator
Production of novel pladienolide analogues through native expression of a pathway-specific activator Open
Reactivation of quiescent polyketide production in a domesticated lab strain.
View article: Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, <i>Aspergillus nanangensis</i>
Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, <i>Aspergillus nanangensis</i> Open
Chemical investigation of an undescribed Australian fungus, Aspergillus nanangensis , led to the identification of the nanangenines – a family of seven new and three previously reported drimane sesquiterpenoids. The structures of the nanan…
View article: Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, <i>Aspergillus burnettii</i>
Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, <i>Aspergillus burnettii</i> Open
The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant m…
View article: Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen <i>Parastagonospora nodorum</i>
Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen <i>Parastagonospora nodorum</i> Open
A biosynthetic gene cluster that is significantly upregulated in the fungal wheat pathogen Parastagonospora nodorum during plant infection was reconstructed heterologously in Aspergillus nidulans. This led to the discovery of five new α-py…