Daniel W. Renner
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View article: High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions
High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions Open
Comparative genomic studies of Marek’s disease virus (MDV) have suggested that attenuated and virulent strains share >98% sequence identity. However, these estimates fail to account for variation in regions of the MDV genome harboring tand…
View article: High-Fidelity Long-Read Sequencing of an Avian Herpesvirus Reveals Extensive Intrapopulation Diversity in Tandem Repeat Regions
High-Fidelity Long-Read Sequencing of an Avian Herpesvirus Reveals Extensive Intrapopulation Diversity in Tandem Repeat Regions Open
Comparative genomic studies of Marek's disease virus (MDV) have suggested that attenuated and virulent strains share >98% sequence identity. However, these estimates fail to account for variation in regions of the MDV genome harboring tand…
View article: Comparative analysis of multiple consensus genomes of the same strain of Marek’s disease virus reveals intrastrain variation
Comparative analysis of multiple consensus genomes of the same strain of Marek’s disease virus reveals intrastrain variation Open
Current strategies to understand the molecular basis of Marek’s disease virus (MDV) virulence primarily consist of cataloging divergent nucleotides between strains with different phenotypes. However, most comparative genomic studies of MDV…
View article: Comparative Analysis of Multiple Consensus Genomes of the Same Strain of Marek’s Disease Virus Reveals Intrastrain Variation
Comparative Analysis of Multiple Consensus Genomes of the Same Strain of Marek’s Disease Virus Reveals Intrastrain Variation Open
Current strategies to understand the molecular basis of Marek’s disease virus (MDV) virulence primarily consist of cataloguing divergent nucleotides between strains with different phenotypes. However, each MDV strain is typically represent…
View article: Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection
Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection Open
Importance Herpes simplex virus type 1 (HSV-1) is the leading cause of first-episode genital herpes in many countries. Objective To inform counseling messages regarding genital HSV-1 transmission, oral and genital viral shedding patterns a…
View article: Multi-phenotype analysis for enhanced classification of 11 herpes simplex virus 1 strains
Multi-phenotype analysis for enhanced classification of 11 herpes simplex virus 1 strains Open
Herpes simplex virus 1 (HSV1) is best known for causing oral lesions and mild clinical symptoms, but it can produce a significant range of disease severities and rates of reactivation. To better understand this phenotypic variation, we cha…
View article: Dermatitis during Spaceflight Associated with HSV-1 Reactivation
Dermatitis during Spaceflight Associated with HSV-1 Reactivation Open
Human alpha herpesviruses herpes simplex virus (HSV-1) and varicella zoster virus (VZV) establish latency in various cranial nerve ganglia and often reactivate in response to stress-associated immune system dysregulation. Reactivation of E…
View article: Genome Sequence of the Virulent Model Herpes Simplex Virus 1 Strain McKrae Demonstrates the Presence of at Least Two Widely Used Variant Strains
Genome Sequence of the Virulent Model Herpes Simplex Virus 1 Strain McKrae Demonstrates the Presence of at Least Two Widely Used Variant Strains Open
Herpes simplex virus 1 (HSV-1) strain McKrae was isolated in 1965 and has been utilized by many laboratories. Three HSV-1 strain McKrae stocks have been sequenced previously, revealing discrepancies in key genes. We sequenced the genome of…
View article: Viral infection of human neurons triggers strain-specific differences in host neuronal and viral transcriptomes
Viral infection of human neurons triggers strain-specific differences in host neuronal and viral transcriptomes Open
Infection with herpes simplex virus 1 (HSV-1) occurs in over half the global population, causing recurrent orofacial and/or genital lesions. Individual strains of HSV-1 demonstrate differences in neurovirulence in vivo , suggesting that vi…
View article: In vitro evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in cell culture
In vitro evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in cell culture Open
The large dsDNA virus herpes simplex virus 1 (HSV-1) is considered to be genetically stable, yet it can rapidly evolve in response to strong selective pressures such as antiviral treatment. Deep sequencing has revealed that clinical and la…
View article: Personalized viral genomic investigation of herpes simplex virus 1 perinatal viremic transmission with dual fatality
Personalized viral genomic investigation of herpes simplex virus 1 perinatal viremic transmission with dual fatality Open
Here we present a personalized viral genomics approach to investigating a rare case of perinatal herpes simplex virus 1 (HSV-1) transmission that ended in death of both mother and neonate. We sought to determine whether the virus involved …
View article: <i>In vitro</i>evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in Vero cell culture
<i>In vitro</i>evolution of herpes simplex virus 1 (HSV-1) reveals selection for syncytia and other minor variants in Vero cell culture Open
The large dsDNA virus HSV-1 is often considered to be genetically stable, however it is known to rapidly evolve in response to strong selective pressures such as antiviral drug treatment. Deep sequencing analysis has revealed that clinical…
View article: Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population
Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population Open
Herpes simplex virus (HSV) causes invasive disease in half of infected neonates, resulting in significant mortality and permanent cognitive morbidity. The factors that contribute to invasive disease are not understood. This study revealed …
View article: Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection
Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection Open
Herpes simplex viruses (HSV) infect a majority of adults. Recent data have highlighted the genetic diversity of HSV-1 strains and demonstrated apparent genomic relatedness between strains from the same geographic regions. We used HSV-1 cli…
View article: Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time
Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time Open
Here we present genomic and in vitro analyses of temporally separated episodes of herpes simplex virus type 1 (HSV-1) shedding by an HSV-1-seropositive and human immunodeficiency virus (HIV)/HSV-2-seronegative individual who has frequent r…
View article: Genotypic and phenotypic diversity within the neonatal HSV-2 population
Genotypic and phenotypic diversity within the neonatal HSV-2 population Open
More than 14,000 neonates are infected with herpes simplex virus (HSV) annually. Approximately half display manifestations limited to the skin, eyes, or mouth (SEM disease). The rest develop invasive infections that spread to the central n…
View article: Impacts of Genome-Wide Analyses on Our Understanding of Human Herpesvirus Diversity and Evolution
Impacts of Genome-Wide Analyses on Our Understanding of Human Herpesvirus Diversity and Evolution Open
Until fairly recently, genome-wide evolutionary dynamics and within-host diversity were more commonly examined in the context of small viruses than in the context of large double-stranded DNA viruses such as herpesviruses. The high mutatio…
View article: DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples
DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples Open
Despite both clinical and laboratory data that show increased virulence in field isolates of MDV-1 over the last half century, we do not yet understand the genetic basis of its pathogenicity. Our knowledge of genome-wide variation between …
View article: DNA from dust: comparative genomics of large DNA viruses in field surveillance samples
DNA from dust: comparative genomics of large DNA viruses in field surveillance samples Open
The intensification of the poultry industry over the last sixty years facilitated the evolution of increased virulence and vaccine breaks in Marek’s disease virus (MDV-1). Full genome sequences are essential for understanding why and how t…
View article: VirAmp: a galaxy-based viral genome assembly pipeline
VirAmp: a galaxy-based viral genome assembly pipeline Open
Background Advances in next generation sequencing make it possible to obtain high-coverage sequence data for large numbers of viral strains in a short time. However, since most bioinformatics tools are developed for command line use, the s…