Daniel W. Trott
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CD4+ T cells do not contribute to age-related arterial dysfunction in mice 3630 Open
Description Previously we have demonstrated that T cells accumulate in the arteries of old (22-24mo) animals. We have also demonstrated that pharmacological depletion of pan (CD3+) and cytotoxic (CD8+) T cells results in improved large art…
T cell specific eomesodermin knockout does not impact adipose senescence burden in middle aged mice 3073 Open
Description Cellular senescence is a state of permanent cell cycle arrest that results in inflammation. Eomes is a transcription factor involved in the transitioning of naïve T cells to memory T cells as well as T cell cytotoxicity. Eomes+…
View article: Elevated LDL-C induces T-cell metabolic dysfunction and increases inflammation and oxidative stress in midlife adults
Elevated LDL-C induces T-cell metabolic dysfunction and increases inflammation and oxidative stress in midlife adults Open
We evaluated the effect of low-density lipoprotein cholesterol (LDL-C) exposure on human T-cells isolated from midlife adults. T-cells were exposed to physiologically low and borderline high concentrations of LDL-C. We observed that high L…
View article: IL-6 induces mitochondrial ROS production and blunts NO bioavailability in human aortic endothelial cells
IL-6 induces mitochondrial ROS production and blunts NO bioavailability in human aortic endothelial cells Open
In this study, we provide evidence that IL-6 induces mitochondrial ROS production, which impairs nitric oxide bioavailability in human aortic endothelial cells. This finding adds an important perspective to the existing literature on the m…
The role of T cells in vascular aging, hypertension, and atherosclerosis Open
Vascular dysfunction has emerged as a significant risk factor for the development of cardio- and cerebrovascular diseases (CVDs), which are currently the leading cause of morbidity and mortality worldwide. T lymphocytes (T cells) have been…
View article: CD8<sup>+</sup> T-cell metabolism is related to cerebrovascular reactivity in middle-aged adults
CD8<sup>+</sup> T-cell metabolism is related to cerebrovascular reactivity in middle-aged adults Open
Peripheral T-cell metabolism is related to in vivo cerebrovascular reactivity in humans. Higher glycolytic metabolism in CD8 + T cells was associated with lower cerebrovascular reactivity to a breath-hold in middle-aged adults, which is po…
View article: <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
<i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension Open
BACKGROUND: CD8 + T cells (CD8Ts) have been implicated in hypertension. However, the specific mechanisms are not fully understood. In this study, we explore the contribution of the P2X7 (purinergic receptor P2X7) receptor to CD8T activatio…
Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis Open
Atherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeabil…
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age Open
Aging results in an elevated burden of senescent cells, senescence‐associated secretory phenotype (SASP), and tissue infiltration of immune cells contributing to chronic low‐grade inflammation and a host of age‐related diseases. Recent evi…
School of ‘hard NOX’ for the ageing artery Open
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View article: Immunomodulation in age‐related disorders and nanotechnology interventions
Immunomodulation in age‐related disorders and nanotechnology interventions Open
Recently, the aging population has increased exponentially around the globe bringing more challenges to improve quality of life in those populations while reducing the economic burden on healthcare systems. Aging is associated with changes…
View article: Augmented T-cell mitochondrial reactive oxygen species in adults with major depressive disorder
Augmented T-cell mitochondrial reactive oxygen species in adults with major depressive disorder Open
To our knowledge, we provide the first evidence of augmented T-cell mitochondrial reactive oxygen species (T-cell mitoROS) in young, otherwise healthy adults with MDD. Although the elevated T-cell mitoROS did not correspond to a proinflamm…
Early Life Thymectomy Induces Glucose Intolerance in Middle-Aged Mice Open
Previously we have found that T cells contribute to age-related glucose intolerance. The purpose of this study was to test the hypothesis that early life thymectomy at 3wks of age induces T cell aging and subsequent impairments in glucose …
View article: T cells mediate cell non‐autonomous arterial ageing in mice
T cells mediate cell non‐autonomous arterial ageing in mice Open
Key points Increased large artery stiffness and impaired endothelium‐dependent dilatation occur with advanced age. We sought to determine whether T cells mechanistically contribute to age‐related arterial dysfunction. We found that old mic…
Pro-inflammatory CD8 T Cells Contribute to Age-Related Large Artery Stiffening Open
We have shown that T cells accumulate around the aorta with advanced age and that both pharmacologic and genetic deletion of total T cells result in improved large artery stiffness in old mice. The purpose of this study was to test the hyp…
Oligoclonal CD8+ T Cells Play a Critical Role in the Development of Hypertension Open
Recent studies have emphasized a role of adaptive immunity, and particularly T cells, in the genesis of hypertension. We sought to determine the T-cell subtypes that contribute to hypertension and renal inflammation in angiotensin II-induc…
Old Mice Exhibit Greater Skeletal Muscle Cxcl10 Gene Expression Open
Advanced age is associated with impairments in glucose tolerance increasing the risk for metabolic syndrome and type II diabetes. Preliminary data from our lab demonstrates greater T-cell infiltration in the skeletal muscle with age and th…
Age Related Alterations in Chemokine and Chemokine Receptor Gene Expression in Mouse Hearts Open
Data from our lab and others demonstrate that there is greater cardiac T cell infiltration with age and that these T cells play a role in pathogenic cardiac hypertrophy and fibrosis. However, how T cells are recruited to the heart with adv…
Inflammation as a mediator of arterial ageing Open
New Findings What is the topic of this review? This review summarizes and synthesizes what is known about the contribution of inflammation to age‐related arterial dysfunction. What advances does it highlight? This review details observatio…
Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways Open
Summary Inhibition of mammalian target of rapamycin, mTOR , extends lifespan and reduces age‐related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age‐r…