Danny R. Welch
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View article: ER-mitochondria tethering and its signaling: A novel therapeutic target in breast cancer
ER-mitochondria tethering and its signaling: A novel therapeutic target in breast cancer Open
Communication between the endoplasmic reticulum (ER) and mitochondria through mitochondria-associated ER membranes (MAMs) is assisted by tethering proteins and signaling pathways, manifesting the dynamic exchange of lipids, calcium, and si…
View article: Automated landmark-based symmetric and standard alignment of skull base structures on CT
Automated landmark-based symmetric and standard alignment of skull base structures on CT Open
This study demonstrates a simple landmark-based technique for aligning the cochleas on head CT studies while approximating whole head AC-PC orientation, which has applications in both clinical and research settings, particularly for studie…
View article: Summer Cancer Research Experience for High School Students from Historically Marginalized Populations in Kansas City
Summer Cancer Research Experience for High School Students from Historically Marginalized Populations in Kansas City Open
The Accelerate Cancer Education (ACE) summer research program at The University of Kansas Cancer Center (KUCC) is a six-week, cancer-focused, summer research experience for high school students from historically marginalized populations in…
View article: Understanding the need for digital twins’ data in patient advocacy and forecasting oncology
Understanding the need for digital twins’ data in patient advocacy and forecasting oncology Open
Digital twins are made of a real-world component where data is measured and a virtual component where those measurements are used to parameterize computational models. There is growing interest in applying digital twins-based approaches to…
View article: TABLE 1 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
TABLE 1 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
Participant characteristics
View article: TABLE 1 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
TABLE 1 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
Participant characteristics
View article: TABLE 2 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
TABLE 2 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
The best-fit model – evaluating the financial factors across four cancer type patients (breast, lung, prostate, and colon)
View article: TABLE 3 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
TABLE 3 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
Logistic regression of full model of main effects
View article: TABLE 2 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
TABLE 2 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
The best-fit model – evaluating the financial factors across four cancer type patients (breast, lung, prostate, and colon)
View article: Data from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
Data from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
How the socioeconomic factors intersect for a particular patient can determine their susceptibility to financial toxicity, what costs they will encounter during treatment, the type and quality of their care, and the potential work impairme…
View article: Data from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
Data from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
How the socioeconomic factors intersect for a particular patient can determine their susceptibility to financial toxicity, what costs they will encounter during treatment, the type and quality of their care, and the potential work impairme…
View article: TABLE 3 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
TABLE 3 from Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
Logistic regression of full model of main effects
View article: Functional inhibition of the <scp>RNA</scp>‐binding protein <scp>HuR</scp> sensitizes triple‐negative breast cancer to chemotherapy
Functional inhibition of the <span>RNA</span>‐binding protein <span>HuR</span> sensitizes triple‐negative breast cancer to chemotherapy Open
Chemotherapy remains the standard treatment for triple‐negative breast cancer (TNBC); however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R (HuR) could be a potential therapeutic target to enhance the chem…
View article: Career disruption and limitation of financial earnings due to cancer
Career disruption and limitation of financial earnings due to cancer Open
Purpose This study investigated how cancer diagnosis and treatment lead to career disruption and, consequently, loss of income and depletion of savings. Design This study followed a qualitative descriptive design that allowed us to underst…
View article: Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status
Evaluating Work Impairment as a Source of Financial Toxicity in Cancer Healthcare and Negative Impacts on Health Status Open
How the socioeconomic factors intersect for a particular patient can determine their susceptibility to financial toxicity, what costs they will encounter during treatment, the type and quality of their care, and the potential work impairme…
View article: Data from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells
Data from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells Open
Breast cancer metastasis suppressor-1 (BRMS1) differentially regulates the expression of multiple genes, leading to metastasis suppression without affecting orthotopic tumor growth. For the first time, BRMS1 promoter methylation was evalua…
View article: Supplementary Figure Legend from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis
Supplementary Figure Legend from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis Open
PDF file - 68K
View article: Data from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells
Data from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells Open
Breast cancer metastasis suppressor-1 (BRMS1) differentially regulates the expression of multiple genes, leading to metastasis suppression without affecting orthotopic tumor growth. For the first time, BRMS1 promoter methylation was evalua…
View article: Supplementary Figure Legend from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis
Supplementary Figure Legend from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis Open
PDF file - 68K
View article: Supplementary Figure 1 from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis
Supplementary Figure 1 from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis Open
PDF file - 159K
View article: Supplementary Table 1 from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells
Supplementary Table 1 from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells Open
PDF 111KB, Oligonucleotide sequences of BRMS1 primers used in this study.
View article: Supplementary Figure 1 from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis
Supplementary Figure 1 from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis Open
PDF file - 159K
View article: Data from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis
Data from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis Open
Dysregulated Notch signaling plays an important role in the progression of cancer. Notch signaling affects tumor growth and angiogenesis through the actions of its ligand Jagged-1. In this study, we developed a novel compound 3,5-bis(2,4-d…
View article: Supplementary Table 1 from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells
Supplementary Table 1 from Breast Cancer Metastasis Suppressor-1 Promoter Methylation in Primary Breast Tumors and Corresponding Circulating Tumor Cells Open
PDF 111KB, Oligonucleotide sequences of BRMS1 primers used in this study.
View article: Data from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis
Data from 3,5-Bis(2,4-Difluorobenzylidene)-4-piperidone, a Novel Compound That Affects Pancreatic Cancer Growth and Angiogenesis Open
Dysregulated Notch signaling plays an important role in the progression of cancer. Notch signaling affects tumor growth and angiogenesis through the actions of its ligand Jagged-1. In this study, we developed a novel compound 3,5-bis(2,4-d…
View article: Supplemental Figure 3 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 3 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 3. Integrative analysis of methylation and gene expression. The methylation level for the five most differentially expressed genes (listed at the top of each page), for which also methylation data was available, is show…