Daniel Whitehouse
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View article: A Technical Assessment of a Commercial GFAP Lateral Flow Assay to Establish Proof-of-Concept for Use in Traumatic Brain Injury
A Technical Assessment of a Commercial GFAP Lateral Flow Assay to Establish Proof-of-Concept for Use in Traumatic Brain Injury Open
View article: Association of Blood-Based Biomarkers and 6-Month Patient-Reported Outcomes in Patients With Mild TBI
Association of Blood-Based Biomarkers and 6-Month Patient-Reported Outcomes in Patients With Mild TBI Open
Participants with higher biomarker levels had greater odds of impaired functional recovery. However, in CT-negative participants, higher GFAP concentrations were associated with better HRQoL and less impaired mental health. Further explora…
View article: Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury
Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury Open
European Union 7th Framework program (EC grant 602150), Hannelore Kohl Stiftung, One Mind, Integra LifeSciences, Neuro-Trauma Sciences, NIHR Rosetrees Trust.
View article: Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study
Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study Open
View article: Time to resolution of symptoms and recovery after mild traumatic brain injury: protocol for a systematic review and meta-analysis
Time to resolution of symptoms and recovery after mild traumatic brain injury: protocol for a systematic review and meta-analysis Open
Introduction Mild traumatic brain injury (mTBI) is a leading cause of morbidity and mortality, with approximately 1 out of 200 people each year sustaining an mTBI in Europe. There is a growing awareness that recovery may take months or yea…
View article: Feasibility of Federated Learning from Client Databases with Different Brain Diseases and MRI Modalities
Feasibility of Federated Learning from Client Databases with Different Brain Diseases and MRI Modalities Open
Segmentation models for brain lesions in MRI are typically developed for a specific disease and trained on data with a predefined set of MRI modalities. Such models cannot segment the disease using data with a different set of MRI modaliti…
View article: Feasibility and benefits of joint learning from MRI databases with different brain diseases and modalities for segmentation
Feasibility and benefits of joint learning from MRI databases with different brain diseases and modalities for segmentation Open
Models for segmentation of brain lesions in multi-modal MRI are commonly trained for a specific pathology using a single database with a predefined set of MRI modalities, determined by a protocol for the specific disease. This work explore…
View article: Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans
Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans Open
Repeated mild traumatic brain injury is of growing interest regarding public and sporting safety and is thought to have greater adverse or cumulative neurological effects when compared with single injury. While epidemiological links betwee…
View article: Journal update monthly top five
Journal update monthly top five Open
View article: Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury: A CENTER-TBI study
Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury: A CENTER-TBI study Open
View article: Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review.
Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review. Open
BACKGROUND: Blood biomarkers are of increasing importance in the diagnosis and assessment of traumatic brain injury (TBI). However, the relationship between them and lesions seen on imaging remains unclear. OBJECTIVE: To perform a systemat…
View article: Transductive image segmentation: Self-training and effect of uncertainty estimation
Transductive image segmentation: Self-training and effect of uncertainty estimation Open
Semi-supervised learning (SSL) uses unlabeled data during training to learn better models. Previous studies on SSL for medical image segmentation focused mostly on improving model generalization to unseen data. In some applications, howeve…
View article: Head injury and concussion in cricket: Incidence, current guidance, and implications of sports concussion literature
Head injury and concussion in cricket: Incidence, current guidance, and implications of sports concussion literature Open
Concussion following head injury remains a significant cause of injury in cricket, with recent high profile events highlighting the ongoing risk of head injury in the sport and the emerging use of concussion assessments for elite players f…
View article: 361 The relationship between intracranial MRI abnormalities and post-concussive symptoms in ED patients with a normal CT: as demonstrated on the Rivermead Post Concussion Symptom Questionnaire (RPQ)
361 The relationship between intracranial MRI abnormalities and post-concussive symptoms in ED patients with a normal CT: as demonstrated on the Rivermead Post Concussion Symptom Questionnaire (RPQ) Open
Aims/Objectives/Background Mild traumatic brain injury (TBI) is common presentation to the ED. Mild, however, is a misnomer with 10–40% of patients suffering from post-concussion symptoms for months to years following injury. 1 2 Patients …
View article: 358 The relationship between serum biomarkers of traumatic brain injury (TBI) and magnetic resonance imaging (MRI) in patients discharged from the emergency department (ED) with a normal acute CT
358 The relationship between serum biomarkers of traumatic brain injury (TBI) and magnetic resonance imaging (MRI) in patients discharged from the emergency department (ED) with a normal acute CT Open
Aims/Objectives/Background CT remains the neuroimaging of choice in patients with TBI, however the relative lack of sensitivity as compared to MRI for certain traumatic lesion types, including diffuse axonal injury (DAI), could lead to mis…
View article: The neurological sequelae of pandemics and epidemics
The neurological sequelae of pandemics and epidemics Open
Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limi…
View article: Multiclass semantic segmentation and quantification of traumatic brain injury lesions on head CT using deep learning: an algorithm development and multicentre validation study
Multiclass semantic segmentation and quantification of traumatic brain injury lesions on head CT using deep learning: an algorithm development and multicentre validation study Open
View article: Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients: A CENTER-TBI Study
Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients: A CENTER-TBI Study Open
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may be associat…
View article: Relationship Between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute TBI Patients: an Exploratory Analysis
Relationship Between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute TBI Patients: an Exploratory Analysis Open
View article: Sparse Representation of 3D Images for Piecewise Dimensionality\n Reduction with High Quality Reconstruction
Sparse Representation of 3D Images for Piecewise Dimensionality\n Reduction with High Quality Reconstruction Open
Sparse representation of 3D images is considered within the context of data\nreduction. The goal is to produce high quality approximations of 3D images\nusing fewer elementary components than the number of intensity points in the 3D\narray…