Daniel Witvliet
YOU?
Author Swipe
View article: Post-embryonic maturation of the <i>C. elegans</i> motor circuit
Post-embryonic maturation of the <i>C. elegans</i> motor circuit Open
Summary During development, animals can maintain behavioral output even as the underlying circuits structurally remodel. After hatching, C. elegans undergoes substantial motor neuron expansion and synapse re-wiring while the animal continu…
View article: Structural Analysis of the Caenorhabditis elegans Dauer Larval Anterior Sensilla by Focused Ion Beam-Scanning Electron Microscopy
Structural Analysis of the Caenorhabditis elegans Dauer Larval Anterior Sensilla by Focused Ion Beam-Scanning Electron Microscopy Open
At the end of the first larval stage, the nematode Caenorhabditis elegans developing in harsh environmental conditions is able to choose an alternative developmental path called the dauer diapause. Dauer larvae exhibit different physiology…
View article: Connectomes across development reveal principles of brain maturation
Connectomes across development reveal principles of brain maturation Open
These data sets belong to the following publication: Witvliet, D., Mulcahy, B., Mitchell, J.K. et al. Connectomes across development reveal principles of brain maturation. Nature 596, 257–261 (2021). https://doi.org/10.1038/s41586-021-0377…
View article: Connectomes across development reveal principles of brain maturation
Connectomes across development reveal principles of brain maturation Open
These data sets belong to the following publication: Witvliet, D., Mulcahy, B., Mitchell, J.K. et al. Connectomes across development reveal principles of brain maturation. Nature 596, 257–261 (2021). https://doi.org/10.1038/s41586-021-0377…
View article: Structural Analysis of the Caenorhabditis elegans Dauer Larval Anterior Sensilla by Focused Ion Beam-Scanning Electron Microscopy
Structural Analysis of the Caenorhabditis elegans Dauer Larval Anterior Sensilla by Focused Ion Beam-Scanning Electron Microscopy Open
These data sets belong to the following publication: Britz S, Markert SM, Witvliet D, Steyer AM, Tröger S, Mulcahy B, Kollmannsberger P, Schwab Y, Zhen M and Stigloher C (2021) Structural Analysis of the Caenorhabditis elegans Dauer Larval…
View article: Structural Analysis of the Caenorhabditis elegans Dauer Larval Anterior Sensilla by Focused Ion Beam-Scanning Electron Microscopy
Structural Analysis of the Caenorhabditis elegans Dauer Larval Anterior Sensilla by Focused Ion Beam-Scanning Electron Microscopy Open
These data sets belong to the following publication: Britz S, Markert SM, Witvliet D, Steyer AM, Tröger S, Mulcahy B, Kollmannsberger P, Schwab Y, Zhen M and Stigloher C (2021) Structural Analysis of the Caenorhabditis elegans Dauer Larval…
View article: Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce a symmetric undulation
Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce a symmetric undulation Open
Summary In many animals, there is a direct correspondence between the motor patterns that drive locomotion and the motor neuron innervation onto the muscle groups. For example, the adult C. elegans moves with symmetric and alternating dors…
View article: Structural analysis of the <i>C. elegans</i> dauer larval anterior sensilla by Focused Ion Beam-Scanning Electron Microscopy
Structural analysis of the <i>C. elegans</i> dauer larval anterior sensilla by Focused Ion Beam-Scanning Electron Microscopy Open
At the end of the first larval stage, the nematode Caenorhabditis elegans developing in harsh environmental conditions is able to choose an alternative developmental path called the dauer diapause. Dauer larvae exhibit different physiology…
View article: Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling
Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling Open
Environmental factors such as temperature affect neuronal activity and development. However, it remains unknown whether and how they affect synaptic subcellular specificity. Here, using the nematode Caenorhabditis elegans AIY interneurons …
View article: Natural sensory context drives diverse brain-wide activity during<i>C. elegans</i>mating
Natural sensory context drives diverse brain-wide activity during<i>C. elegans</i>mating Open
Natural goal-directed behaviors often involve complex sequences of many stimulus-triggered components. Understanding how brain circuits organize such behaviors requires mapping the interactions between an animal, its environment, and its n…
View article: Corrigendum: A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System
Corrigendum: A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System Open
[This corrects the article DOI: 10.3389/fncir.2018.00094.].
View article: A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System
A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System Open
The “connectome,” a comprehensive wiring diagram of synaptic connectivity, is achieved through volume electron microscopy (vEM) analysis of an entire nervous system and all associated non-neuronal tissues. White et al. (1986) pioneered the…
View article: <scp>3D</scp> mapping of subcellular structures with super‐resolution array tomography
<span>3D</span> mapping of subcellular structures with super‐resolution array tomography Open
The combination of fluorescence light microscopy (FLM) and electron microscopy (EM) makes it possible to put molecular identity in its full ultrastructural context. With array tomography (AT) long ribbons of serial ultrathin sections are l…
View article: Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the<i>C. elegans</i>connectome
Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the<i>C. elegans</i>connectome Open
Correlating molecular labeling at the ultrastructural level with high confidence remains challenging. Array tomography (AT) allows for a combination of fluorescence and electron microscopy (EM) to visualize subcellular protein localization…
View article: ELASPIC web-server: proteome-wide structure-based prediction of mutation effects on protein stability and binding affinity
ELASPIC web-server: proteome-wide structure-based prediction of mutation effects on protein stability and binding affinity Open
Summary: ELASPIC is a novel ensemble machine-learning approach that predicts the effects of mutations on protein folding and protein–protein interactions. Here, we present the ELASPIC webserver, which makes the ELASPIC pipeline available t…