Yan D. Zhao
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List of contributors Open
View article: Steering Autoregressive Music Generation with Recursive Feature Machines
Steering Autoregressive Music Generation with Recursive Feature Machines Open
Controllable music generation remains a significant challenge, with existing methods often requiring model retraining or introducing audible artifacts. We introduce MusicRFM, a framework that adapts Recursive Feature Machines (RFMs) to ena…
View article: Exploring the pharmacological action mechanism of chamomile essential oil on the treatment of breast cancer based on network pharmacology
Exploring the pharmacological action mechanism of chamomile essential oil on the treatment of breast cancer based on network pharmacology Open
Our research suggest that CEO inhibit proliferation of breast cancer cell lines through modulating those multi-pathways and multi-targets. The present study not only indicate the therapeutic potential of CEO for breast cancer, but also pro…
View article: Towards Interpretable and Inference-Optimal COT Reasoning with Sparse Autoencoder-Guided Generation
Towards Interpretable and Inference-Optimal COT Reasoning with Sparse Autoencoder-Guided Generation Open
We propose a novel method that leverages sparse autoencoders (SAEs) and clustering techniques to analyze the internal token representations of large language models (LLMs) and guide generations in mathematical reasoning tasks. Our approach…
View article: Banxia-Xiexin Decoction Ameliorates Colitis-Associated Colorectal Cancer by Modulating Inflammatory Responses and the Complement and Coagulation Cascade Pathway
Banxia-Xiexin Decoction Ameliorates Colitis-Associated Colorectal Cancer by Modulating Inflammatory Responses and the Complement and Coagulation Cascade Pathway Open
BXD may ameliorate CAC by modulating inflammatory responses and glycerophospholipid metabolism, with particular involvement of the complement and coagulation cascades. These findings provide mechanistic insight into the potential anti-CAC …
View article: Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota
Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota Open
Deoxynivalenol (DON), a mycotoxin from Fusarium that contaminates cereals, can also induce intestinal injury. However, the mechanisms underlying DON-induced jejunal barrier injury remain unclear. This study demonstrates that shikimic acid …
View article: Epigenetic regulation of bladder cancer in the context of aging
Epigenetic regulation of bladder cancer in the context of aging Open
Bladder cancer (BC) is a disease that predominantly affects older adults, with aging playing a critical role in its onset and progression. Age-associated phenomena, including immunosenescence and chronic inflammation, form a pro-tumor mili…
View article: Development and validation of a deep-learning algorithm for rule-in and rule-out coronary artery disease based on electrocardiogram without evidence of myocardial ischemia
Development and validation of a deep-learning algorithm for rule-in and rule-out coronary artery disease based on electrocardiogram without evidence of myocardial ischemia Open
Our algorithm based on ECG without myocardial ischemia evidence performed good in CAD detection. An algorithm-based decision-making protocol could achieve the guideline-recommended performance in guiding rule-out or rule-in for further exa…
View article: [Exogenous triggering with hCG/GnRHa improves outcomes of natural cycle IVF/ICSI in patients with diminished ovarian reserve: a propensity score matching and logistic regression analysis].
[Exogenous triggering with hCG/GnRHa improves outcomes of natural cycle IVF/ICSI in patients with diminished ovarian reserve: a propensity score matching and logistic regression analysis]. Open
For DOR patients undergoing NC-IVF/ICSI, exogenous triggering comprehensively improves the treatment outcomes, particularly providing significant live birth benefits for women aged 35-40 years. An individualized protocol incorporating the …
View article: Investigating Protective Effect of Suspension of Paeoniflorin in Combination with Curcumin Against Acute Liver Injury Based on Inhibition of TLR4/NF-κB/NLRP3 Inflammatory Pathway
Investigating Protective Effect of Suspension of Paeoniflorin in Combination with Curcumin Against Acute Liver Injury Based on Inhibition of TLR4/NF-κB/NLRP3 Inflammatory Pathway Open
The objective of this study was to formulate a compound suspension comprising paeoniflorin and curcumin, assess its quality characteristics, and investigate its protective efficacy against acute liver injury in mice. The prescriptions were…
View article: Fetal Weight Extrapolation Following a Third-Trimester Ultrasound Examination Using the Gestation-Adjusted Projection Method: A Systematic Review and Meta-analysis
Fetal Weight Extrapolation Following a Third-Trimester Ultrasound Examination Using the Gestation-Adjusted Projection Method: A Systematic Review and Meta-analysis Open
Using systematic review and meta-analysis methodology, we sought to evaluate the accuracy of the gestation-adjusted projection (GAP) method of fetal weight extrapolation in the prediction of actual birth weight. A systematic literature sea…
View article: A Phase 1b Study of Avelumab Plus Bacillus Calmette-Guérin in Patients With Nonmuscle-Invasive Bladder Cancer
A Phase 1b Study of Avelumab Plus Bacillus Calmette-Guérin in Patients With Nonmuscle-Invasive Bladder Cancer Open
Purpose: The optimal management of Bacillus Calmette-Guérin (BCG)-unresponsive nonmuscle-invasive bladder cancer (NMIBC) remains unclear. This study evaluated the safety and tolerability of a novel intense immunotherapy dosing regimen of a…
View article: Identification and Characterization of Oxidative Stress and Endoplasmic Reticulum Stress-Related Genes in Esophageal Cancer
Identification and Characterization of Oxidative Stress and Endoplasmic Reticulum Stress-Related Genes in Esophageal Cancer Open
Increasing evidence highlights the critical roles of oxidative stress and endoplasmic reticulum (ER) stress in tumor initiation and progression. However, the specific functions of related genes in esophageal cancer (ESCA) remain poorly und…
View article: A Randomized Controlled Trial of Ergonomic Risk in Pediatric Adenotonsillectomy
A Randomized Controlled Trial of Ergonomic Risk in Pediatric Adenotonsillectomy Open
Objective This study aims to compare the intraoperative ergonomics of tonsillectomies and adenoidectomies performed in seated versus standing positions for pediatric otolaryngology residents and attending physicians. Study Design A randomi…
View article: Modulation of double-negative T cells by Huang-Lian-Jie-Du Decoction attenuates neuroinflammation in ischemic stroke: insights from single-cell transcriptomics
Modulation of double-negative T cells by Huang-Lian-Jie-Du Decoction attenuates neuroinflammation in ischemic stroke: insights from single-cell transcriptomics Open
Introduction Ischemic stroke (IS) represents a significant global health challenge, characterized by elevated morbidity and mortality rates, largely driven by inflammatory responses. Double-negative T cells (DNTs), a distinct subset of T c…
View article: Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury
Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury Open
This study aimed to investigate the potential protective properties of a traditional Chinese medicine (TCM) herbal product, Siraitia grosvenorii granules (SGG) against PM2.5-induced lung injury, as well as their active constituents and und…
View article: Abstract #14: Older cervical cancer patients are inadequately screened prior to diagnosis: an opportunity for improvement
Abstract #14: Older cervical cancer patients are inadequately screened prior to diagnosis: an opportunity for improvement Open
View article: The Predictive Synthesis of Monodisperse and Biocompatible Gold Nanoparticles
The Predictive Synthesis of Monodisperse and Biocompatible Gold Nanoparticles Open
The predictive bottom-up synthesis of monodisperse and biocompatible gold nanoparticles using seed-mediated growth procedures is limited by a lack of mathematical models relating reaction components to the final nanoparticle diameter. In t…
View article: Policy Gradients for Optimal Parallel Tempering MCMC
Policy Gradients for Optimal Parallel Tempering MCMC Open
Parallel tempering is a meta-algorithm for Markov Chain Monte Carlo that uses multiple chains to sample from tempered versions of the target distribution, enhancing mixing in multi-modal distributions that are challenging for traditional m…
View article: Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy
Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy Open
View article: Association between vitamin B2 intake and prostate-specific antigen in American men: 2003–2010 National Health and Nutrition Examination Survey
Association between vitamin B2 intake and prostate-specific antigen in American men: 2003–2010 National Health and Nutrition Examination Survey Open
Background Accumulating evidence suggests a pivotal role of vitamin B2 in the pathogenesis and progression of prostate cancer (PCa). Vitamin B2 intake has been postulated to modulate the screening rate for PCa by altering the concentration…
View article: Prediction of coronary artery disease based on facial temperature information captured by non-contact infrared thermography
Prediction of coronary artery disease based on facial temperature information captured by non-contact infrared thermography Open
Background Current approaches for initial coronary artery disease (CAD) assessment rely on pretest probability (PTP) based on risk factors and presentations, with limited performance. Infrared thermography (IRT), a non-contact technology t…
View article: Exploring the Pharmacological Action Mechanism of Chamomile Essential Oil on the Treatment of Breast Cancer Based on Network Pharmacology
Exploring the Pharmacological Action Mechanism of Chamomile Essential Oil on the Treatment of Breast Cancer Based on Network Pharmacology Open
Background Chamomile essential oil (CEO) can be beneficial in cancer therapy. The aim of the current research is to explore the underlying mechanism of CEO for breast cancer treatment by network pharmacology approach and evaluate its anti-…
View article: Systematic Review and Meta‐Analysis of Endovascular Therapy Effectiveness for Unruptured Saccular Intracranial Aneurysms
Systematic Review and Meta‐Analysis of Endovascular Therapy Effectiveness for Unruptured Saccular Intracranial Aneurysms Open
Background Currently, endovascular treatment of intracranial aneurysms is limited by low complete occlusion rates. The advent of novel endovascular technology has expanded the applicability of endovascular therapies; however, the superiori…
View article: Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells
Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells Open
Chemotherapy and radiotherapy resistance are major obstacles in the long-term efficacy of head and neck squamous cell carcinoma (HNSCC) treatment. Secondhand smoke (SHS) exposure is common and has been proposed as an independent predictor …
View article: Cardiac Myosin Autoantibodies Promote a Fibrotic Transcriptome and Reduced Ventricular Recovery in Human Myocarditis
Cardiac Myosin Autoantibodies Promote a Fibrotic Transcriptome and Reduced Ventricular Recovery in Human Myocarditis Open
View article: Exploring and Analyzing the Systemic Delivery Barriers for Nanoparticles
Exploring and Analyzing the Systemic Delivery Barriers for Nanoparticles Open
Most nanomedicines require efficient in vivo delivery to elicit meaningful diagnostic and therapeutic effects. However, en route to their intended tissues, systemically administered nanoparticles often encounter delivery barriers. To descr…
View article: Network pharmacology-based approach to investigate the molecular targets of essential oil obtained from lavender for treating breast cancer
Network pharmacology-based approach to investigate the molecular targets of essential oil obtained from lavender for treating breast cancer Open
Lavender essential oil (LEO) is known for its medicinal use in the development of pharmaceuticals. Further investigations were demonstrated that LEO has many biological properties including apoptosis. However, The anti-breast cancer activi…
View article: Choosing Statistical Models to Assess Biological Interaction as a Departure from Additivity of Effects
Choosing Statistical Models to Assess Biological Interaction as a Departure from Additivity of Effects Open
Vanderweele and Knol define biological interaction as an instance wherein “two exposures physically interact to bring about the outcome.” A hallmark of biological interaction is that the total effect, produced when factors act together, di…
View article: Corrigendum: IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes
Corrigendum: IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes Open
[This corrects the article DOI: 10.3389/fcvm.2022.919700.].