Daniel Yerly
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View article: Undressing DReSS as p-i mediated disease
Undressing DReSS as p-i mediated disease Open
Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) is a severe T cell-mediated hypersensitivity reaction. T cells in DReSS are stimulated via the p-i mechanism (pharmacological interaction with immune receptors), where the drug …
View article: The Cyto-LTT: A multiplex cytokine assay to detect and assess the strength of T cell reactivity in drug hypersensitivity
The Cyto-LTT: A multiplex cytokine assay to detect and assess the strength of T cell reactivity in drug hypersensitivity Open
Cyto-LTT reveals dose-dependent T cell activation in delayed drug hypersensitivity reactions, challenging the notion that drug allergic reactions are dose-independent. The assay not only identifies the culprit drug but also quantifies immu…
View article: Flow Cytometry‐Assisted Analyses of Individual Human Basophils, Mast Cells and T Cells in the Diagnosis of Immediate Drug Hypersensitivity: A Review
Flow Cytometry‐Assisted Analyses of Individual Human Basophils, Mast Cells and T Cells in the Diagnosis of Immediate Drug Hypersensitivity: A Review Open
Immediate drug hypersensitivity reactions (IDHRs) pose significant diagnostic challenges, often requiring potentially hazardous drug challenge testing (DCT). Flow cytometry‐based cellular tests including the basophil activation test (BAT),…
View article: Proceedings of the 15 <sup>th</sup> European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals
Proceedings of the 15 <sup>th</sup> European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals Open
The European Immunogenicity Platform (EIP) celebrated the 15th edition of its Open Symposium on Immunogenicity of Biopharmaceuticals and its associated one-day workshop on 22-24 February 2024 in Lisbon. The meeting attracted experts and ne…
View article: Drug hypersensitivity and eosinophilia: The decisive role of p‐i stimulation
Drug hypersensitivity and eosinophilia: The decisive role of p‐i stimulation Open
Eosinophilia is a common finding in drug hypersensitivity reactions (DHR). Its cause is unclear, as neither antigen/allergen‐driven inflammation nor clonal expansion is involved. Most delayed‐DHRs are due to p‐i ( p harmacologic interactio…
View article: Clinical and immunological data from chronic urticaria onset after mRNA SARS‐CoV‐2 vaccines
Clinical and immunological data from chronic urticaria onset after mRNA SARS‐CoV‐2 vaccines Open
The Swiss regulatory agency approved BNT 162b2 from Pfizer-BioNTech and mRNA-1273 from Moderna in December 2020 and January 2021, respectively. A third vaccine dose (booster) was recommended by the end of October 2021. Although the vast ma…
View article: Intradermal Testing With COVID-19 mRNA Vaccines Predicts Tolerance
Intradermal Testing With COVID-19 mRNA Vaccines Predicts Tolerance Open
Background The newly developed mRNA-based COVID-19 vaccines can provoke anaphylaxis, possibly induced by polyethylene glycol (PEG) contained in the vaccine. The management of persons with a history of PEG allergy or with a suspected allerg…
View article: Risk Assessment in Drug Hypersensitivity: Detecting Small Molecules Which Outsmart the Immune System
Risk Assessment in Drug Hypersensitivity: Detecting Small Molecules Which Outsmart the Immune System Open
Drug hypersensitivity (DH) reactions are clinically unusual because the underlying immune stimulations are not antigen-driven, but due to non-covalent drug-protein binding. The drugs may bind to immune receptors like HLA or TCR which elici…
View article: The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions
The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions Open
Rationale β-lactam antibiotics cause drug hypersensitivity reactions (DHR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions and anaphylaxis. Current…
View article: Long COVID 1 year after hospitalisation for COVID-19: a prospective bicentric cohort study
Long COVID 1 year after hospitalisation for COVID-19: a prospective bicentric cohort study Open
AIMS OF THE STUDY: There is increasing interest in better understanding of long COVID, a condition characterised by long-term sequelae — appearing or persisting after the typical convalescence period — of coronavirus disease 2019 (COVID-19…
View article: Pre-vaccination allergy testing with COVID-19 mRNA vaccines predicts tolerance
Pre-vaccination allergy testing with COVID-19 mRNA vaccines predicts tolerance Open
Background: The newly developed mRNA-based COVID-19 vaccines can provoke anaphylaxis, possibly induced by polyethylene glycol (PEG) contained in the vaccine. The management of persons with a history of PEG allergy, or with an allergic-like…
View article: Highly specific and reliable in vitro diagnostic analysis of memory T and B lymphocytes in a Swiss cohort of COVID-19 patients
Highly specific and reliable in vitro diagnostic analysis of memory T and B lymphocytes in a Swiss cohort of COVID-19 patients Open
The SARS-CoV-2 pandemic has claimed many lives and disrupted the quality of life of most individuals. Diagnostic tests not only serve to confirm past exposure but can provide information crucial for guiding healthcare options for patients.…
View article: Massive clonal expansion of polycytotoxic skin and blood CD8 <sup>+</sup> T cells in patients with toxic epidermal necrolysis
Massive clonal expansion of polycytotoxic skin and blood CD8 <sup>+</sup> T cells in patients with toxic epidermal necrolysis Open
This study highlights the key role of polycytotoxic CD8 + T cells in the severity of toxic epidermal necrolysis.
View article: Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS)
Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS) Open
Background A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid tre…
View article: The role of drug, dose, and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndrome
The role of drug, dose, and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndrome Open
Background Multiple drug hypersensitivity syndrome (MDH) is used to describe persons with a drug hypersensitivity reaction (DHR) to at least two chemically unrelated drugs, confirmed by skin test or in vitro assay. Methods Medical records …
View article: Immuno-monitoring reveals an extended subclinical disease activity in tocilizumab-treated giant cell arteritis
Immuno-monitoring reveals an extended subclinical disease activity in tocilizumab-treated giant cell arteritis Open
ClinicalTrials.gov, http://clinicaltrials.gov, NCT01450137.
View article: Structural Elements Recognized by Abacavir-Induced T Cells
Structural Elements Recognized by Abacavir-Induced T Cells Open
Adverse drug reactions are one of the leading causes of morbidity and mortality in health care worldwide. Human leukocyte antigen (HLA) alleles have been strongly associated with drug hypersensitivities, and the causative drugs have been s…
View article: 7th drug hypersensitivity meeting: part one
7th drug hypersensitivity meeting: part one Open
Table of contents\n Oral Abstracts\n O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN\n Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Corne…
View article: Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors
Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors Open
Small chemicals like drugs tend to bind to proteins via noncovalent bonds, e.g. hydrogen bonds, salt bridges or electrostatic interactions. Some chemicals interact with other molecules than the actual target ligand, representing so-called …