Deyin Guo
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View article: Coronaviral nsp6 hijacks ERAD machinery to facilitate lipolysis and supply membrane components for DMV growth
Coronaviral nsp6 hijacks ERAD machinery to facilitate lipolysis and supply membrane components for DMV growth Open
The positive-strand RNA ( + RNA) viruses extensively remodel cellular endomembranes to facilitate viral replication, with coronaviruses forming a specialized viral replication organelle (RO) known as double-membrane vesicles (DMVs). These …
View article: Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification
Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification Open
Rapid and accurate detection of infectious virus particles, not just viral nucleic acid, is essential to avoid unnecessary quarantine and effectively control the spread of viral diseases such as coronavirus disease 2019 (COVID-19), severe …
View article: SegFinder: an automated tool for identifying complete RNA virus genome segments through co-occurrence in multiple sequenced samples
SegFinder: an automated tool for identifying complete RNA virus genome segments through co-occurrence in multiple sequenced samples Open
Metagenomic sequencing has expanded the ribonucleic acid (RNA) virosphere, but many identified viral genomes remain incomplete, especially for segmented viruses. Traditional methods relying on sequence homology struggle to identify highly …
View article: Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses
Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses Open
Introduction Understanding the intricacies of the host inflammatory response to coronaviruses is essential for developing effective therapeutic strategies to mitigate the severe consequences of these infections. Various coronaviruses can t…
View article: Evidence for fomite transmission of SARS‐CoV‐2 Omicron variant in a mouse model
Evidence for fomite transmission of SARS‐CoV‐2 Omicron variant in a mouse model Open
Impact statement Throughout the COVID‐19 pandemic, the risk of fomite‐based transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has not been systematically investigated. In this study, we employed the K18‐hACE2 mou…
View article: Genome modeling and design across all domains of life with Evo 2
Genome modeling and design across all domains of life with Evo 2 Open
All of life encodes information with DNA. While tools for sequencing, synthesis, and editing of genomic code have transformed biological research, intelligently composing new biological systems would also require a deep understanding of th…
View article: Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial
Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial Open
Background SHEN26 (ATV014) is an oral RNA-dependent RNA polymerase (RdRp) inhibitor with potential anti-SARS-CoV-2 activity. Safety, tolerability, and pharmacokinetic characteristics were verified in a Phase I study. This phase II study ai…
View article: Comprehensive Infectome Analysis Reveals Diverse Infectious Agents with Zoonotic Potential in Wildlife
Comprehensive Infectome Analysis Reveals Diverse Infectious Agents with Zoonotic Potential in Wildlife Open
Understanding wildlife-pathogen interactions is crucial for mitigating zoonotic risk. Through meta-transcriptomic sequencing we profiled the infectomes of 1,922 samples from 67 mammalian species across China, uncovering a remarkable divers…
View article: Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation
Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation Open
Hantaan virus (HTNV) infection causes severe hemorrhagic fever with renal syndrome (HFRS) in humans and the infectious process can be regulated by autophagy. The phosphatase and tensin homolog (PTEN) protein has antiviral effects and plays…
View article: Small mammals in a biodiversity hotspot harbor viruses of emergence risk
Small mammals in a biodiversity hotspot harbor viruses of emergence risk Open
Metagenomic sequencing has transformed the understanding of viral diversity in wildlife and the potential threats these viruses pose to human health. Despite this progress, such sequencing studies often have lacked systematic and ecologica…
View article: Using artificial intelligence to document the hidden RNA virosphere
Using artificial intelligence to document the hidden RNA virosphere Open
Current metagenomic tools can fail to identify highly divergent RNA viruses. We developed a deep learning algorithm, termed LucaProt, to discover highly divergent RNA-dependent RNA polymerase (RdRP) sequences in 10,487 metatranscriptomes g…
View article: VirID: Beyond Virus Discovery—An Integrated Platform for Comprehensive RNA Virus Characterization
VirID: Beyond Virus Discovery—An Integrated Platform for Comprehensive RNA Virus Characterization Open
RNA viruses exhibit vast phylogenetic diversity and can significantly impact public health and agriculture. However, current bioinformatics tools for viral discovery from metagenomic data frequently generate false positive virus results, o…
View article: Small mammals in biodiversity hotspot harbor viruses of epidemic potential
Small mammals in biodiversity hotspot harbor viruses of epidemic potential Open
Metagenomic sequencing has transformed our understanding of viral diversity in wildlife and its threat to human health. Despite this progress, many studies have lacked systematic and ecologically informed sampling, which has left numerous …
View article: SARS-CoV-2 NSP16 promotes IL-6 production by regulating the stabilization of HIF-1α
SARS-CoV-2 NSP16 promotes IL-6 production by regulating the stabilization of HIF-1α Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of coronavirus disease 2019 (COVID-19). Severe and fatal COVID-19 cases often display cytokine storm i.e. significant elevation of pro-inflammatory cytokin…
View article: The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression
The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression Open
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes widespread changes in epigenetic modifications and chromatin architecture in the host cell. Recent evidence suggests that SARS-CoV-2 nonstructural prote…
View article: SegFinder: an automated tool for identifying RNA virus genome segments through co-occurrence in multiple sequenced samples
SegFinder: an automated tool for identifying RNA virus genome segments through co-occurrence in multiple sequenced samples Open
Metagenomic sequencing has expanded the RNA virosphere, but many identified viral genomes remain incomplete, especially for segmented viruses. Traditional methods relying on sequence homology struggle to identify highly divergent segments …
View article: VirID: Beyond Virus Discovery - An Integrated Platform for Comprehensive RNA Virus Characterization
VirID: Beyond Virus Discovery - An Integrated Platform for Comprehensive RNA Virus Characterization Open
RNA viruses exhibit vast phylogenetic diversity and can significantly impact public health and agriculture. However, current bioinformatics tools for viral discovery from metagenomic data frequently generate false positive virus results, o…
View article: CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity Open
Protein aggregation caused by the disruption of proteostasis will lead to cellular cytotoxicity and even cell death, which is implicated in multiple neurodegenerative diseases. The elimination of aggregated proteins is mediated by selectiv…
View article: Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16
Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16 Open
The ongoing COVID-19 pandemic still threatens human health around the world. The methyltransferases (MTases) of SARS-CoV-2, specifically nsp14 and nsp16, play crucial roles in the methylation of the N7 and 2′-O positions of viral RNA, maki…
View article: Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19
Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 Open
The RNA-dependent RNA polymerase (RdRp), 3C-like protease (3CL pro ), and papain-like protease (PL pro ) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as promising therapeutic targets. Currently, all FDA-approved…
View article: Reconstitution of RNA cap methylation reveals different features of SARS‐CoV‐2 and SARS‐CoV methyltransferases
Reconstitution of RNA cap methylation reveals different features of SARS‐CoV‐2 and SARS‐CoV methyltransferases Open
Cap RNA methylations play important roles in the replication, evasion of host RNA sensor recognition, and pathogenesis. Coronaviruses possess both guanine N7‐ and 2′‐O‐ribose methyltransferases (N7‐MTase and 2′‐O‐MTase) encoded by nonstruc…