Daniel Y. Bargieri
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View article: Anti-malarial contact dependent blocking of transmission of <i>Plasmodium vivax</i> by <i>Anopheles darlingi</i> mosquito vector
Anti-malarial contact dependent blocking of transmission of <i>Plasmodium vivax</i> by <i>Anopheles darlingi</i> mosquito vector Open
Malaria, caused by protozoa of the genus Plasmodium and transmitted to humans through the bite of mosquitoes of the genus Anopheles , remains a public health problem. Long-Lasting Insecticide -treated bed Nets (LLINS) and Indoor Residual S…
View article: Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin
Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin Open
Fosmidomycin was proposed as an antimalarial drug but failed in clinical trials due to recrudescence, a phenomenon whose causes remain poorly understood. The mechanism of action of fosmidomycin is the inhibition of the methylerythritol 4-p…
View article: Expression and purification of <scp>E140</scp> protein antigen fragments of <i>Plasmodium vivax</i> and <i>Plasmodium berghei</i> for serological assays
Expression and purification of <span>E140</span> protein antigen fragments of <i>Plasmodium vivax</i> and <i>Plasmodium berghei</i> for serological assays Open
Malaria, a life‐threatening disease caused by Plasmodium parasites, continues to pose a significant global health threat, with nearly 250 million infections and over 600 000 deaths reported annually by the WHO. Fighting malaria is particul…
View article: Smartphone-based retrospective analysis for malaria hotspot detection
Smartphone-based retrospective analysis for malaria hotspot detection Open
Sickness Positioning System demonstrates a cost-effective, objective, and timely method for identifying malaria transmission hotspots. This approach has the potential to significantly enhance disease surveillance and facilitate more target…
View article: A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants Open
Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is imperiled by widespread partial artemisinin resistance in Southeast Asia and its…
View article: Pyrimidine Azepine Targets the <i>Plasmodium bc</i><sub>1</sub> Complex and Displays Multistage Antimalarial Activity
Pyrimidine Azepine Targets the <i>Plasmodium bc</i><sub>1</sub> Complex and Displays Multistage Antimalarial Activity Open
Malaria control and elimination efforts would benefit from the identification and validation of new malaria chemotherapeutics. Recently, a transgenic Plasmodium berghei line was used to perform a series of high-throughput in vitro screens …
View article: QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities
QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities Open
Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved …
View article: Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria
Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria Open
Aim: Computer-aided drug design approaches were applied to identify chalcones with antiplasmodial activity. Methodology: The virtual screening was performed as follows: structural standardization of in-house database of chalcones; identifi…
View article: Innovative Multistage ML-QSAR Models for Malaria: From Data to Discovery
Innovative Multistage ML-QSAR Models for Malaria: From Data to Discovery Open
Malaria presents a significant challenge to global public health, with around 247 million cases estimated to occur annually worldwide. The growing resistance of Plasmodium parasites to existing therapies underscores the urgent need for new…
View article: Characterisation of the merozoite thrombospondin related anonymous protein (MTRAP) of Plasmodium berghei as a transmission-blocking antigen
Characterisation of the merozoite thrombospondin related anonymous protein (MTRAP) of Plasmodium berghei as a transmission-blocking antigen Open
Our results indicate that antibodies to PbMTRAP may reduce but are not sufficient to completely block transmission.
View article: Transcriptomics-Guided In Silico Drug Repurposing: Identifying New Candidates with Dual-Stage Antiplasmodial Activity
Transcriptomics-Guided In Silico Drug Repurposing: Identifying New Candidates with Dual-Stage Antiplasmodial Activity Open
In tropical and subtropical areas, malaria stands as a profound public health challenge, causing an estimated 247 million cases worldwide annually. Given the absence of a viable vaccine, the timely and effective treatment of malaria remain…
View article: Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the improved treatment of malaria caused by Plasmodium vivax
Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the improved treatment of malaria caused by Plasmodium vivax Open
Malaria is a global parasitic infection that leads to substantial illness and death. The most commonly-used drugs for treatment of malaria vivax are primaquine and chloroquine, but they have limitations, such as poor adherence due to frequ…
View article: Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc
Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc Open
Safe and effective malaria transmission-blocking chemotherapeutics would allow a community-level approach to malaria control and eradication efforts by targeting the mosquito sexual stage of the parasite life cycle. However, only a single …
View article: Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc
Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc Open
This is the accepted manuscript version of the work published in its final form as Calit J., Araújo J E., Deng B., Miura K., Gaitán X A., Araújo M D S., Medeiros J F., Long C A., Simeonov A., Eastman R T., & Bargieri D Y. (2023). Novel tra…
View article: Immune System Modulation by the Adjuvants Poly (I:C) and Montanide ISA 720
Immune System Modulation by the Adjuvants Poly (I:C) and Montanide ISA 720 Open
Adjuvants are essential for vaccine development, especially subunit-based vaccines such as those containing recombinant proteins. Increasing the knowledge of the immune response mechanisms generated by adjuvants should facilitate the formu…
View article: Parasitological profiling shows 4(1H)-quinolone derivatives as new lead candidates for malaria
Parasitological profiling shows 4(1H)-quinolone derivatives as new lead candidates for malaria Open
4(1H)-quinolone is an attractive template for antimalarial drug discovery campaigns. Given the current global increase in drug and insecticide resistance, the discovery of new antimalarial drugs is an urgent goal for the fight against mala…
View article: Diagnostic Methods for Non-Falciparum Malaria
Diagnostic Methods for Non-Falciparum Malaria Open
Malaria is a serious public health problem that affects mostly the poorest countries in the world, killing more than 400,000 people per year, mainly children under 5 years old. Among the control and prevention strategies, the differential …
View article: Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity
Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity Open
Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, …
View article: Correction for Ferreira et al., “Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax”
Correction for Ferreira et al., “Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax” Open
Volume 64, no. 9, e02041-19, 2020, https://doi.org/10.1128/AAC.02041-19. Page 1: This article was published on 20 August 2020 with a standard copyright line (“© 2020 American Society for Microbiology. All Rights Reserved.”). The authors el…
View article: Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of <i>P. falciparum</i> Phosphatidylinositol 4-Kinase (<i>Pf</i> PI4KIIIβ)
Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of <i>P. falciparum</i> Phosphatidylinositol 4-Kinase (<i>Pf</i> PI4KIIIβ) Open
Drug resistance is a constant threat to malaria control efforts making it important to maintain a good pipeline of new drug candidates. Of particular need are compounds that also block transmission by targeting sexual stage parasites. Matu…
View article: Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax
Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax Open
Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduc…
View article: Protective Immunity in Mice Immunized With P. vivax MSP119-Based Formulations and Challenged With P. berghei Expressing PvMSP119
Protective Immunity in Mice Immunized With P. vivax MSP119-Based Formulations and Challenged With P. berghei Expressing PvMSP119 Open
The lack of continuous in vitro cultures has been an obstacle delaying pre-clinical testing of Plasmodium vivax vaccine formulations based on known antigens. In this study, we generated a model to test available formulations based on the P…
View article: São Paulo School of Advanced Sciences on Vaccines: an overview
São Paulo School of Advanced Sciences on Vaccines: an overview Open
Two years ago, we held an exciting event entitled the São Paulo School of Advanced Sciences on Vaccines (SPSASV). Sixty-eight Ph.D. students, postdoctoral fellows and independent researchers from 37 different countries met at the Mendes Pl…
View article: Screening the Pathogen Box for Molecules Active against Plasmodium Sexual Stages Using a New Nanoluciferase-Based Transgenic Line of P. berghei Identifies Transmission-Blocking Compounds
Screening the Pathogen Box for Molecules Active against Plasmodium Sexual Stages Using a New Nanoluciferase-Based Transgenic Line of P. berghei Identifies Transmission-Blocking Compounds Open
Malaria remains an important parasitic disease with a large morbidity and mortality burden. Plasmodium transmission-blocking (TB) compounds are essential for achieving malaria elimination efforts.
View article: QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities
QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities Open
Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved …