Dong Shen
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View article: PEAR: Planner-Executor Agent Robustness Benchmark
PEAR: Planner-Executor Agent Robustness Benchmark Open
Large Language Model (LLM)-based Multi-Agent Systems (MAS) have emerged as a powerful paradigm for tackling complex, multi-step tasks across diverse domains. However, despite their impressive capabilities, MAS remain susceptible to adversa…
View article: <i>MDM2</i>Knockdown Reduces the Oncogenic Activities and Enhances NIS Protein Abundance in Papillary Thyroid Cancer
<i>MDM2</i>Knockdown Reduces the Oncogenic Activities and Enhances NIS Protein Abundance in Papillary Thyroid Cancer Open
MDM2 knockdown not only reduced the oncogenic activities of thyroid cancer but also enhanced the intensity of NIS protein responsible for iodine intake in thyroid gland. Therefore, MDM2 could serve as a prognosis indicator in thyroid cance…
View article: Global, regional, and national prevalence and disability-adjusted life-years for endometriosis in 204 countries and territories, 1990–2019: Findings from a global burden of disease study
Global, regional, and national prevalence and disability-adjusted life-years for endometriosis in 204 countries and territories, 1990–2019: Findings from a global burden of disease study Open
The findings of this study reflect the temporal and spatial tendency of the burden of endometriosis during the study period, and provide a reference for health agencies around the world to formulate policies on endometriosis, so as to redu…
View article: Leisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study
Leisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study Open
With the acceleration of population aging, disability in older adults is a growing public health problem; however, little is known about the role of specific leisure-time activities in affecting disability. This study prospectively examine…
View article: METTL14 regulates CD8+T-cell activation and immune responses to anti‐PD‐1 therapy in lung cancer
METTL14 regulates CD8+T-cell activation and immune responses to anti‐PD‐1 therapy in lung cancer Open
Background N6-methyladenosine (m6A) modification plays an important role in lung cancer. However, methyltransferase-like 14 (METTL14), which serves as the main component of the m6A complex, has been less reported to be involved in the immu…
View article: SPINK5 inhibits esophageal squamous cell carcinoma metastasis via immune activity
SPINK5 inhibits esophageal squamous cell carcinoma metastasis via immune activity Open
Background Esophageal squamous cell carcinoma (ESCC) is a predominant subtype of esophageal cancer with relatively high mortality worldwide. Serine peptidase inhibitor Kazal‐type 5 (SPINK5) is reported to be downregulated in ESCC. However,…
View article: Predicting Malignancy in Breast Lesions: Enhancing Accuracy with Fine-Tuned Convolutional Neural Network Models
Predicting Malignancy in Breast Lesions: Enhancing Accuracy with Fine-Tuned Convolutional Neural Network Models Open
Objectives. This study aimed to explore which convolutional neural network (CNN) model is best for predicting the likelihood of malignancy on dynamic contrast-enhanced breast magnetic resonance imaging (DCE-BMRI). Materials and Methods. A …
View article: New Concept, Definition and Clinic of Mixed Unit in Bipolar Disorder
New Concept, Definition and Clinic of Mixed Unit in Bipolar Disorder Open
Objective: To explore a clinical and practical method for diagnosing and evaluating mixed states of bipolar disorder. Method: Starting from a theoretical perspective, to analyze the forms of expression of mixed states, propose a concept th…
View article: Discrimination of benign and malignant breast lesions on dynamic contrast-enhanced magnetic resonance imaging using deep learning
Discrimination of benign and malignant breast lesions on dynamic contrast-enhanced magnetic resonance imaging using deep learning Open
Purpose: To evaluate the capability of deep transfer learning (DTL) and fine-tuning methods in differentiating malignant from benign lesions in breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods: The diagnostic …
View article: Endoscopic therapy versus esophagectomy for T1bN0M0 esophageal cancer: A population-based study using propensity score matching
Endoscopic therapy versus esophagectomy for T1bN0M0 esophageal cancer: A population-based study using propensity score matching Open
Endoscopic therapy and esophagectomy were associated with a significant survival advantage compared with chemoradiotherapy in patients with T1bN0M0 EC. In contrast, after PSM, among the EC patients with stage T1bN0M0, OS and CSS did not di…
View article: Predictive value of <i>DOT1L</i> mutations for clinical outcomes in non‐small‐cell lung cancer patients receiving immune checkpoint inhibitor therapy
Predictive value of <i>DOT1L</i> mutations for clinical outcomes in non‐small‐cell lung cancer patients receiving immune checkpoint inhibitor therapy Open
Dear Editor, In this study, we present findings that highlight the role of baseline Disruptor of telomeric silencing 1-like (DOT1L) mutations as a promising biomarker to identify stage IIIb/IV non-small-cell lung cancer (NSCLC) patients wh…
View article: Classification of Breast Lesions on DCE-MRI Data Using a Fine-Tuned MobileNet
Classification of Breast Lesions on DCE-MRI Data Using a Fine-Tuned MobileNet Open
It is crucial to diagnose breast cancer early and accurately to optimize treatment. Presently, most deep learning models used for breast cancer detection cannot be used on mobile phones or low-power devices. This study intended to evaluate…
View article: Whole β-glucan particle attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation
Whole β-glucan particle attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation Open
Yeast β-glucan is a polysaccharide purified from the Saccharomyces cerevisiae cell wall, and its multiple biological activities are essential for immune regulation. However, the effect of β-glucan on the intestinal immune response during c…
View article: Differentiation of breast lesions on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using deep transfer learning based on DenseNet201
Differentiation of breast lesions on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using deep transfer learning based on DenseNet201 Open
In order to achieve better performance, artificial intelligence is used in breast cancer diagnosis. In this study, we evaluated the efficacy of different fine-tuning strategies of deep transfer learning (DTL) based on the DenseNet201 model…
View article: Is aripiprazole similar to quetiapine for treatment of bipolar depression? Results from meta-analysis of Chinese data
Is aripiprazole similar to quetiapine for treatment of bipolar depression? Results from meta-analysis of Chinese data Open
Objective To study the similarities and differences in the clinical efficacy of aripiprazole and quetiapine in Chinese patients with bipolar depression through meta-analysis. Additionally, to provide evidence of aripiprazole in treatment f…
View article: Lamotrigine and Lithium Combination for Treatment of Rapid Cycling Bipolar Disorder: Results From Meta-Analysis
Lamotrigine and Lithium Combination for Treatment of Rapid Cycling Bipolar Disorder: Results From Meta-Analysis Open
Objective The objective of this study is to observe the effect of combination of lithium and lamotrigine in treatment of rapid-cycling bipolar disorder (RCBD). Method We searched MEDLINE, EMBASE, Cochrane Library in English and CBM, CNKI, …
View article: A Pan-Cancer Study of KMT2 Family as Therapeutic Targets in Cancer
A Pan-Cancer Study of KMT2 Family as Therapeutic Targets in Cancer Open
Objective. Exome sequencing studies have shown that the histone-lysine N-methyltransferase 2 (KMT2) gene is one of the most commonly mutated genes in a range of human malignancies and is linked to some of the most common and deadly solid t…
View article: Efficacy and safety of acupuncture and moxibustion combined with the external application of traditional Chinese medicine in the treatment of primary liver cancer
Efficacy and safety of acupuncture and moxibustion combined with the external application of traditional Chinese medicine in the treatment of primary liver cancer Open
Background: Primary liver cancer (PLC) is one of the most common malignant tumors in the world, and its incidence and fatality rate are increasing year by year. Due to the large population base in China, the aging population is severely af…
View article: CCR4 is a prognostic biomarker and correlated with immune infiltrates in head and neck squamous cell carcinoma
CCR4 is a prognostic biomarker and correlated with immune infiltrates in head and neck squamous cell carcinoma Open
Our study found that CCR4 was a prognostic marker related to HNSC immune infiltration, and patients with high expression of CCR4 had a better prognosis.
View article: Lamotrigine and Lithium Combination for Treatment of Rapid Cycling Bipolar Disorder: Results From Meta-analysis
Lamotrigine and Lithium Combination for Treatment of Rapid Cycling Bipolar Disorder: Results From Meta-analysis Open
Objective: to observe effect of combination of lithium and lamotrigine in treatment for Rapid-cycling bipolar disorder(RCBD). Method: We searched both MEDLINE, EMBASE, Cochrane Library in English and CBM, CNKI, WANFANG and CSSCI in Chinese…
View article: Landscape of <i>IDH1/2</i> mutations in Chinese patients with solid tumors: A pan‐cancer analysis
Landscape of <i>IDH1/2</i> mutations in Chinese patients with solid tumors: A pan‐cancer analysis Open
Background Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. However, the landscape of IDH mutations in pan‐cancer has not been fully characterized. Methods Tissue or blood …
View article: Long noncoding RNA LINC01296 plays an oncogenic role in colorectal cancer by suppressing p15 expression
Long noncoding RNA LINC01296 plays an oncogenic role in colorectal cancer by suppressing p15 expression Open
Objective To examine the role of the long noncoding RNA LINC01296 in colorectal carcinoma (CRC) and to explore the underlying mechanism. Methods We detected LINC01296 expression levels in a cohort of 51 paired CRC and normal tissues. We al…
View article: Clinicopathological characteristics and survival outcomes in neuroendocrine prostate cancer
Clinicopathological characteristics and survival outcomes in neuroendocrine prostate cancer Open
Objective: This study aimed to investigate the clinicopathological features and the survival outcomes of neuroendocrine prostate cancer (NEPC). Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database of the National…
View article: Efficacy of afatinib in a patient with rare EGFR (G724S/R776H) mutations and amplification in lung adenocarcinoma: A case report
Efficacy of afatinib in a patient with rare EGFR (G724S/R776H) mutations and amplification in lung adenocarcinoma: A case report Open
A case of non-small cell lung cancer with rare EGFR G724S/R776H mutations and EGFR amplification responds well to TKI treatment.
View article: Circulating plasma exosomal miRNA profiles serve as potential metastasis‑related biomarkers for hepatocellular carcinoma
Circulating plasma exosomal miRNA profiles serve as potential metastasis‑related biomarkers for hepatocellular carcinoma Open
Exosomes carry functional molecules that can regulate cancer progression. Understanding the function of exosomal markers may provide invaluable insights into the mechanism of metastasis in hepatocellular carcinoma (HCC). The aim of the pre…
View article: Landscape of IDH1/2 mutations in Chinese patients with solid tumors: a pan-cancer analysis
Landscape of IDH1/2 mutations in Chinese patients with solid tumors: a pan-cancer analysis Open
Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. However, the landscape of IDH mutations in pan-cancer has not been fully characterized. Tissue or blood samples were subjec…
View article: Eradication of Hepatitis C Virus (HCV) Improves Survival of Hepatocellular Carcinoma Patients with Active HCV Infection – A Real-World Cohort Study
Eradication of Hepatitis C Virus (HCV) Improves Survival of Hepatocellular Carcinoma Patients with Active HCV Infection – A Real-World Cohort Study Open
Yang Luo,1 Yue Zhang,2 Di Wang,3 Di Shen,2 Yi-Qun Che2 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Colle…