Daniel Zalewski
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View article: Molecular Signatures Related to Inflammation and Angiogenesis in Patients with Lower Extremity Artery Disease, Abdominal Aortic Aneurysm, and Varicose Veins: Shared and Distinct Pathways
Molecular Signatures Related to Inflammation and Angiogenesis in Patients with Lower Extremity Artery Disease, Abdominal Aortic Aneurysm, and Varicose Veins: Shared and Distinct Pathways Open
Lower extremity artery disease (LEAD), abdominal aortic aneurysm (AAA), and varicose veins (VV) are frequently underdiagnosed and undertreated peripheral vascular diseases that pose considerable public health challenges. More research is r…
View article: RQdeltaCT: an open-source R package for relative quantification of gene expression using delta Ct methods
RQdeltaCT: an open-source R package for relative quantification of gene expression using delta Ct methods Open
Relative quantification of gene expression is a fundamental method used in the molecular biology field to analyse real-time PCR data to determine transcriptional differences between groups of samples (or technical replicates of a single sa…
View article: Complicated Diagnosis and Treatment of Rare Painless Acanthamoeba Keratitis
Complicated Diagnosis and Treatment of Rare Painless Acanthamoeba Keratitis Open
Objectives: The aim was to present the complicated diagnostic and therapeutic process of atypical, painless keratitis caused by a cosmopolitan protozoan of the genus Acanthamoeba. Methods: This Case Report describes a medical case involvin…
View article: Key Regulators of Angiogenesis and Inflammation Are Dysregulated in Patients with Varicose Veins
Key Regulators of Angiogenesis and Inflammation Are Dysregulated in Patients with Varicose Veins Open
Varicose veins (VVs) are the most common manifestation of chronic venous disease (CVD) and appear as abnormally enlarged and tortuous superficial veins. VVs result from functional abnormalities in the venous circulation of the lower extrem…
View article: RQdeltaCT: Relative Quantification of Gene Expression using Delta Ct Methods
RQdeltaCT: Relative Quantification of Gene Expression using Delta Ct Methods Open
The commonly used methods for relative quantification of gene expression levels obtained in real-time PCR (Polymerase Chain Reaction) experiments are the delta Ct methods, encompassing 2^-dCt and 2^-ddCt methods, originally proposed by Ken…
View article: Content of selected polyphenolic compounds in four Sambucus nigra l. cultivars in relation to their antimicrobial activity
Content of selected polyphenolic compounds in four Sambucus nigra l. cultivars in relation to their antimicrobial activity Open
European elderberry (Sambucus nigra L.) fruits constitute a valuable source of biologically active compounds useful in the pharmaceutical industry. We aimed to determine the content of chosen polyphenolic compounds in fruit extracts from f…
View article: Chemical Composition, and Antioxidant and Antimicrobial Activity of Oregano Essential Oil
Chemical Composition, and Antioxidant and Antimicrobial Activity of Oregano Essential Oil Open
Antimicrobial resistance (AMR) is a global public health problem, and the rapid rise in AMR is attributed to the inappropriate and/or overuse of antibiotics. Therefore, alternative antimicrobial agents, including those of natural origin, a…
View article: Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm
Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm Open
Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed disease and is burdened with a high mortality rate (65–85%) from AAA rupture…
View article: Dataset used for the article ''Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm".
Dataset used for the article ''Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm". Open
The dataset contains gene expression data and plasma levels data for selected regulators of angiogenesis and inflammation in patients with AAA. Gene expression experiments were performed in peripheral blood mononuclear cells using qPCR. Pl…
View article: Next-Generation Sequencing in the Assessment of the Transcriptomic Landscape of DNA Damage Repair Genes in Abdominal Aortic Aneurysm, Chronic Venous Disease and Lower Extremity Artery Disease
Next-Generation Sequencing in the Assessment of the Transcriptomic Landscape of DNA Damage Repair Genes in Abdominal Aortic Aneurysm, Chronic Venous Disease and Lower Extremity Artery Disease Open
Vascular diseases are one of the most common causes of death and morbidity. Lower extremity artery disease (LEAD), abdominal aortic aneurysm (AAA) and chronic venous disease (CVD) belong to this group of conditions and exhibit various pres…
View article: The Landscape of Gene Expression during Hyperfilamentous Biofilm Development in Oral Candida albicans Isolated from a Lung Cancer Patient
The Landscape of Gene Expression during Hyperfilamentous Biofilm Development in Oral Candida albicans Isolated from a Lung Cancer Patient Open
The filamentation ability of Candida albicans represents one of the main virulence factors allowing for host tissue penetration and biofilm formation. The aim of this paper was to study the genetic background of the hyperfilamentous biofil…
View article: Variation in the Antimicrobial Activity of Essential Oils from Cultivars of Lavandula angustifolia and L. × intermedia
Variation in the Antimicrobial Activity of Essential Oils from Cultivars of Lavandula angustifolia and L. × intermedia Open
The antimicrobial properties of essential oil from Lavandula sp. raise hopes related to its use in phytotherapy. This study aimed to evaluate the antimicrobial activity of essential oils from cultivars of L. angustifolia (‘Hidcote Blue Str…
View article: miRNA Regulatory Networks Associated with Peripheral Vascular Diseases
miRNA Regulatory Networks Associated with Peripheral Vascular Diseases Open
A growing body of evidence indicates a crucial role of miRNA regulatory function in a variety of mechanisms that contribute to the development of diseases. In our previous work, alterations in miRNA expression levels and targeted genes wer…
View article: MicroRNA expression biomarkers of chronic venous disease
MicroRNA expression biomarkers of chronic venous disease Open
Chronic venous disease (CVD) is a common disease caused by hemodynamic disorders of the venous circulation in the lower extremities. The clinical image of this disease is complex and includes such signs as telangiectases, varicose veins, l…
View article: Relationships between Indicators of Lower Extremity Artery Disease and miRNA Expression in Peripheral Blood Mononuclear Cells
Relationships between Indicators of Lower Extremity Artery Disease and miRNA Expression in Peripheral Blood Mononuclear Cells Open
Lower extremity artery disease (LEAD) is an underdiagnosed and globally underestimated vascular disease caused by the progressive and chronic formation of atherosclerotic plaques in the arteries of the lower limbs. Much evidence indicates …
View article: Biomarkers of brain ischemia-reperfusion injury after carotid endarterectomy
Biomarkers of brain ischemia-reperfusion injury after carotid endarterectomy Open
Background: Endarterectomy of the internal carotid artery (CEA) is a surgical procedure used to prevent cerebral ischemic stroke. Available data from previous literature indicates that CEA may lead to complications in the form of cerebral …
View article: miRNA expression data for article 'Relationships between Indicators of Lower Extremity Artery Disease and miRNA Expression in Peripheral Blood Mononu-clear Cells'
miRNA expression data for article 'Relationships between Indicators of Lower Extremity Artery Disease and miRNA Expression in Peripheral Blood Mononu-clear Cells' Open
Raw read counts of 2,792 miRNAs obtained using Ion S5XL NGS platform in peripheral blood mononuclear cells collected from 40 patients with lower extremity artery disease.This dataset is was generated for the paper:'Relationships between In…
View article: Expression_data_figshare.xlsx
Expression_data_figshare.xlsx Open
MicroRNA raw read counts resulted from RNA sequencing (Ion Torrent S5 XL platform) of PBMCs samples collected from 40 patients with lower extremity artery disease (LEAD), 28 patients with abdominal aortic aneurysm (AAA) and 34 patients wit…
View article: Raw Crt data
Raw Crt data Open
Raw Crt data of 754 miRNAs obtained using RT-qPCR experiments with OpenArray technology. Expression profiles were obtained in peripheral blood mononuclear cells collected from 18 patients with lower extremity artery disease and 10 control …
View article: miRNA expression data for article 'Relationships between Indicators of Lower Extremity Artery Disease and miRNA Expression in Peripheral Blood Mononuclear Cells'
miRNA expression data for article 'Relationships between Indicators of Lower Extremity Artery Disease and miRNA Expression in Peripheral Blood Mononuclear Cells' Open
Raw read counts of 2,792 miRNAs obtained using Ion S5XL NGS platform in peripheral blood mononuclear cells collected from 40 patients with lower extremity artery disease.This dataset is was generated for the paper:Zalewski, D.P.; Ruszel, K…
View article: miRNA expression data
miRNA expression data Open
MicroRNA raw read counts resulted from RNA sequencing (Ion Torrent S5 XL platform) of PBMCs samples collected from 40 patients with lower extremity artery disease (LEAD), 28 patients with abdominal aortic aneurysm (AAA) and 34 patients wit…
View article: Raw expression data for genes related to DNA repair and metabolism
Raw expression data for genes related to DNA repair and metabolism Open
Data: raw expression data (read counts) for 519 genes related to DNA repair and metabolism.Method: Next Generation Sequencing using Ion Torrent S5XL platform.Samples: peripheral blood mononuclear cells isolated from wh…
View article: Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy – short report
Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy – short report Open
Background: Endarterectomy of the internal carotid artery (CEA) plays an important role in the prevention of cerebral ischemic stroke; however, this surgical procedure may cause neurological complications. The aim of this study was to eval…
View article: MicroRNAs in the aqueous humor of patients with different types of glaucoma
MicroRNAs in the aqueous humor of patients with different types of glaucoma Open
Purpose The aim of the study was to compare the frequency and the level of expression of selected miRNAs in the aqueous humor of patients with various types of glaucoma. Methods The studied group consisted of 42 patients with glaucoma: 19 …
View article: Transient Thermal Analysis of the Circuit Breaker Current Path with the Use of FEA Simulation
Transient Thermal Analysis of the Circuit Breaker Current Path with the Use of FEA Simulation Open
The finite element analysis (FEA) is an essential and powerful numerical method that can explicitly optimize the design process of electrical devices. In this paper, the employment of the finite element method (FEM) as ANSYS is proposed in…
View article: Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens
Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens Open
Several human tissues are investigated in studies of molecular biomarkers associated with diseases development. Special attention is focused on the blood and its components due to combining abundant information about systemic responses to …
View article: The Correlation of Mutations and Expressions of Genes within the PI3K/Akt/mTOR Pathway in Breast Cancer—A Preliminary Study
The Correlation of Mutations and Expressions of Genes within the PI3K/Akt/mTOR Pathway in Breast Cancer—A Preliminary Study Open
There is an urgent need to seek new molecular biomarkers helpful in diagnosing and treating breast cancer. In this elaboration, we performed a molecular analysis of mutations and expression of genes within the PI3K/Akt/mTOR pathway in pati…
View article: Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens - Dataset
Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens - Dataset Open
Gene raw reads counts resulted from RNA sequencing (Ion Torrent S5 XL platform) of PBMCs samples.This dataset was used to perform analyses described in the paper:Zalewski, D.P.; Ruszel, K.P.; Stępniewski, A.; Gałkowski, D.; Bogucki, J.; Ko…
View article: Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm
Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm Open
Abdominal artery aneurysm (AAA) refers to abdominal aortic dilatation of 3 cm or greater. AAA is frequently underdiagnosed due to often asymptomatic character of the disease, leading to elevated mortality due to aneurysm rupture. MiRNA con…
View article: Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease
Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease Open
Chronic venous disease (CVD) is a vascular disease of lower limbs with high prevalence worldwide. Pathologic features include varicose veins, venous valves dysfunction and skin ulceration resulting from dysfunction of cell proliferation, a…