Daniel Zalko
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View article: A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health
A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health Open
Bisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodev…
View article: Endocrine-disrupting chemical concentrations in follicular fluid and follicular reproductive hormone levels
Endocrine-disrupting chemical concentrations in follicular fluid and follicular reproductive hormone levels Open
Purpose To determine correlations between chemicals in follicular fluid (FF) and follicular reproductive hormone levels. Methods The analysis was part of a larger cohort study to determine associations between exposure to EDCs and in vitro…
View article: The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA)
The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA) Open
We strongly endorse EFSA's revised TDI for BPA and support the European Commission's (EC) apparent acceptance of this updated BPA risk assessment. We discuss challenges to current chemical risk assessment assumptions about EDCs that need t…
View article: Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project Open
[This corrects the article DOI: 10.3389/ftox.2023.1212509.].
View article: Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment
Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment Open
New approach methodologies (NAMs) have the potential to become a major component of regulatory risk assessment, however, their actual implementation is challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC)…
View article: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project Open
In past times, the analysis of endocrine disrupting properties of chemicals has mainly been focused on (anti-)estrogenic or (anti-)androgenic properties, as well as on aspects of steroidogenesis and the modulation of thyroid signaling. Mor…
View article: Ranking food products based on estimating and combining their microbiological, chemical and nutritional risks: Method and application to Ready-To-Eat dishes sold in France
Ranking food products based on estimating and combining their microbiological, chemical and nutritional risks: Method and application to Ready-To-Eat dishes sold in France Open
Microbiological (M), chemical (C), and nutritional (N) risks associated with food products are usually assessed and managed independently by experts in public services or food companies. This can render difficult the comparison of food pro…
View article: Gestational exposure to bisphenol A induces region-specific changes in brain metabolomic fingerprints in sheep
Gestational exposure to bisphenol A induces region-specific changes in brain metabolomic fingerprints in sheep Open
Fetal brain development depends on maternofetal thyroid function. In rodents and sheep, perinatal BPA exposure is associated with maternal and/or fetal thyroid disruption and alterations in central nervous system development as demonstrate…
View article: OBEMIRISK‐Knowledge platform for assessing the risk of bisphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers
OBEMIRISK‐Knowledge platform for assessing the risk of bisphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers Open
International audience
View article: Modulation of hepatic xenobiotic metabolizing enzymes following chronic low-dose exposure to PFOA in mice
Modulation of hepatic xenobiotic metabolizing enzymes following chronic low-dose exposure to PFOA in mice Open
Meeting abstract56th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology of the Next Generation, 27septembre-1er octobre 2021
View article: Transgenerational metabolomic fingerprints in mice ancestrally exposed to the obesogen TBT
Transgenerational metabolomic fingerprints in mice ancestrally exposed to the obesogen TBT Open
This study is the first application of metabolomics to unveil the transgenerational effects of EDC exposure. Very early, significant changes in the plasma metabolome were observed in animals ancestrally exposed to TBT. These changes preced…
View article: Additional file 4 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 4 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 3. List of all genes detected in the microarray experiment, log(fold-changes), raw p-values and corrected p-values for inter-group comparisons.
View article: Additional file 7 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 7 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 6 Gene lists for sex-biased genes. (A) List of genes significantly higher in males Pxr+/+ compared to females Pxr+/+ (male-biased genes). (B) List of genes significantly higher in males Pxr-/- compared to females Pxr-/-. (C…
View article: Additional file 6 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 6 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 5 Gene lists and GO enrichment analyses for Pxr-/- vs Pxr+/+ transcriptome comparisons. (A) List of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. (B) GO term enrichment analysis using the list o…
View article: Additional file 9 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 9 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 8 Gene lists and GO enrichment analyses for ATB- vs. Cont. transcriptome comparisons. (A) List of genes significantly up-regulated in males Pxr+/+ ATB compared to males Pxr+/+ Cont. (B) GO term enrichment analysis using the…
View article: Addendum: An Optimised Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples. Metabolites 2020, 10, 338
Addendum: An Optimised Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples. Metabolites 2020, 10, 338 Open
The authors wish to make the following comment to the paper [...]
View article: An Optimized Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples
An Optimized Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples Open
The functional understanding of metabolic changes requires both a significant investigation into metabolic pathways, as enabled by global metabolomics and lipidomics approaches, and the comprehensive and accurate exploration of specific ke…
View article: Synergic toxic effects of food contaminant mixtures in human cells
Synergic toxic effects of food contaminant mixtures in human cells Open
Humans are exposed to multiple exogenous substances, notably through food consumption. Many of these compounds are suspected to impact human health, and their combination could exacerbate their harmful effects. We previously observed in hu…
View article: The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds
The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds Open
The purpose of this project report is to introduce the European “GOLIATH” project, a new research project which addresses one of the most urgent regulatory needs in the testing of endocrine-disrupting chemicals (EDCs), namely the lack of m…
View article: Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation
Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation Open
Being able to explore the metabolism of broad metabolizing cells is of critical importance in many research fields. This article presents an original modeling solution combining metabolic network and omics data to identify modulated metabo…
View article: Comparison of the metabolism of 10 chemicals in human and pig skin explants
Comparison of the metabolism of 10 chemicals in human and pig skin explants Open
Skin metabolism is important to consider when assessing local toxicity and/or penetration of chemicals and their metabolites. If human skin supply is limited, pig skin can be used as an alternative. To identify any species differences, we …