Daniela Bossi
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View article: Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output Program in Prostate Cancer
Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output Program in Prostate Cancer Open
SUMMARY Activation of the androgen receptor (AR) is the key lineage-specific oncogenic pathway and the primary therapeutic target in prostate cancer. While AR signaling is enabled by the pioneer transcription factor FOXA1, its homolog FOXA…
View article: TRIM24 Degradation Counteracts Adaptation to Androgen Receptor Inhibition in Prostate Cancer
TRIM24 Degradation Counteracts Adaptation to Androgen Receptor Inhibition in Prostate Cancer Open
The androgen receptor (AR) is the primary therapeutic target in prostate cancer. While androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSi) are effective, the disease eventually progresses to fatal castratio…
View article: TRIM24 as a therapeutic target in endocrine treatment–resistant breast cancer
TRIM24 as a therapeutic target in endocrine treatment–resistant breast cancer Open
While Estrogen receptor alpha (ERα)+ breast cancer treatment is considered effective, resistance to endocrine therapy is common. Since ERα is still the main driver in most therapy-resistant tumors, alternative therapeutic strategies are ne…
View article: GPNMB marks a quiescent cell population in melanoma and promotes metastasis formation
GPNMB marks a quiescent cell population in melanoma and promotes metastasis formation Open
Melanoma exhibits high intratumoral heterogeneity, characterized by a diverse population of cells undergoing dynamic transitions between cellular states. These adaptive changes enable melanoma cells to survive in the harsh tumor microenvir…
View article: An integrated proteomic portrait of prostate cancer progression
An integrated proteomic portrait of prostate cancer progression Open
Cancer forms a local tumor that subsequently metastasizes to distant organs. In prostate cancer, the latter part of the trajectory is influenced by the inhibition of the androgen receptor (AR). The study of proteomic changes along disease …
View article: <i>IN VIVO</i>ISOLATION OF A QUIESCENT MELANOMA POPULATION WITH INVASIVE PROPERTIES UNVEILS A TRANSCRIPTIONAL REPROGRAMMING DRIVEN BY THE TUMOR NICHE
<i>IN VIVO</i>ISOLATION OF A QUIESCENT MELANOMA POPULATION WITH INVASIVE PROPERTIES UNVEILS A TRANSCRIPTIONAL REPROGRAMMING DRIVEN BY THE TUMOR NICHE Open
Melanoma is a heterogeneous tumor composed of many interacting cellular populations and highly plastic melanoma cells that pass through distinct cell states to adapt to the surrounding microenvironment. Slow cycling is a transient state th…
View article: Supplementary Tables S1 - S5 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Supplementary Tables S1 - S5 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
Supplementary Table S1. Patient Demographics, and Clinical Characteristics of the Metastatic Cutaneous Melanomas and the Patient-derived xenografts (PDXs). Supplementary Table S2. A, Analysis of the epigenetic screening performed in MM13, …
View article: Supplementary Figures S1 - S8 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Supplementary Figures S1 - S8 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
Supplementary Figure S1 shows IHC analysis of metastatic melanoma tissues of MM13, MM16, and MM27 patients and their paired PDX1/PDX2. Supplementary Figure S2 shows exome sequencing analysis of human metastatic melanoma MM13, MM16, and MM2…
View article: Data from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Data from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
The identification of genes maintaining cancer growth is critical to our understanding of tumorigenesis. We report the first in vivo genetic screen of patient-derived tumors, using metastatic melanomas and targeting 236 chromatin genes by …
View article: Data from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Data from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
The identification of genes maintaining cancer growth is critical to our understanding of tumorigenesis. We report the first in vivo genetic screen of patient-derived tumors, using metastatic melanomas and targeting 236 chromatin genes by …
View article: Supplementary Methods, Figure Legends from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Supplementary Methods, Figure Legends from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
Supplementary Methods, Figure Legends
View article: Supplementary Figures S1 - S8 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Supplementary Figures S1 - S8 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
Supplementary Figure S1 shows IHC analysis of metastatic melanoma tissues of MM13, MM16, and MM27 patients and their paired PDX1/PDX2. Supplementary Figure S2 shows exome sequencing analysis of human metastatic melanoma MM13, MM16, and MM2…
View article: Supplementary Tables S1 - S5 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Supplementary Tables S1 - S5 from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
Supplementary Table S1. Patient Demographics, and Clinical Characteristics of the Metastatic Cutaneous Melanomas and the Patient-derived xenografts (PDXs). Supplementary Table S2. A, Analysis of the epigenetic screening performed in MM13, …
View article: Supplementary Methods, Figure Legends from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
Supplementary Methods, Figure Legends from <i>In Vivo</i> Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Open
Supplementary Methods, Figure Legends
View article: Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression.
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression. Open
Comprehensive genomic studies have delineated key driver mutations linked to disease progression for most cancers. However, corresponding transcriptional changes remain largely elusive because of the bias associated with cross-study analys…
View article: Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer
Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer Open
Driver genes with a mutually exclusive mutation pattern across tumor genomes are thought to have overlapping roles in tumorigenesis. In contrast, we show here that mutually-exclusive prostate cancer driver alterations involving the ERG tra…
View article: Modeling cell proliferation in human acute myeloid leukemia xenografts
Modeling cell proliferation in human acute myeloid leukemia xenografts Open
Motivation Acute myeloid leukemia (AML) is one of the most common hematological malignancies, characterized by high relapse and mortality rates. The inherent intra-tumor heterogeneity in AML is thought to play an important role in disease …
View article: WDR5 regulates epithelial-to-mesenchymal transition in breast cancer cells<i>via</i>TGFβ
WDR5 regulates epithelial-to-mesenchymal transition in breast cancer cells<i>via</i>TGFβ Open
Even if the mortality rate in breast cancer (BC) has recently decreased, development of metastases and drug resistance are still challenges to successful systemic treatment. The epithelial-to-mesenchymal transition (EMT), as well as epigen…
View article: PO-178 WDR5 promotes metastasis dissemination in breast cancer
PO-178 WDR5 promotes metastasis dissemination in breast cancer Open
Results and discussions In this study, we identified a membrane-anchored serine protease inhibitor, hepatocyte growth factor activator inhibitor-2 (HAI-2), was down-regulated in human prostate and lung cancer.The decreased levels of HAI-2 …
View article: Dual modulation of MCL-1 and mTOR determines the response to sunitinib
Dual modulation of MCL-1 and mTOR determines the response to sunitinib Open
Most patients who initially respond to treatment with the multi-tyrosine kinase inhibitor sunitinib eventually relapse. Therefore, developing a deeper understanding of the contribution of sunitinib's numerous targets to the clinical respon…
View article: RNAi screens identify CHD4 as an essential gene in breast cancer growth
RNAi screens identify CHD4 as an essential gene in breast cancer growth Open
Epigenetic regulation plays an essential role in tumor development and epigenetic modifiers are considered optimal potential druggable candidates. In order to identify new breast cancer vulnerabilities and improve therapeutic chances for p…