Daniela Burau
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View article: Assessment of dose optimisation requirements in special patient populations in the field of endocrinology and infectiology
Assessment of dose optimisation requirements in special patient populations in the field of endocrinology and infectiology Open
Drug therapy is always at risk of over- or underdosing resulting in inefficient treatment or adverse drug reactions. To find an optimal dose of a drug is therefore crucial. However, determination of the “right dose” is challenging due to s…
View article: Pharmacokinetics of Cefuroxime in Synovial Fluid
Pharmacokinetics of Cefuroxime in Synovial Fluid Open
Cefuroxime is frequently used as preoperative antibiotic prophylaxis and may be used for the treatment of septic arthritis. A prerequisite for successful treatment of septic arthritis is the ability of an antibiotic agent to penetrate into…
View article: Penetration of linezolid into synovial fluid and muscle tissue after elective arthroscopy
Penetration of linezolid into synovial fluid and muscle tissue after elective arthroscopy Open
Linezolid may be used to treat septic arthritis caused by bacterial strains with an MIC ≤1 mg/L. Assuming a pharmacokinetic/pharmacodynamic target of > 50 for AUC0-24/MIC, when treating strains with an MIC >1 mg/L treatment surveillance is…
View article: Quality of compounded hydrocortisone capsules used in the treatment of children
Quality of compounded hydrocortisone capsules used in the treatment of children Open
Objectives Due to the lack of paediatric-licensed formulations, children are often treated with individualized pharmacy-compounded adult medication. An international web-based survey about the types of medication in children with adrenal i…