Explanipedia

Astrocytes modulate neuronal development by S100A6 signaling Open

Valentina Cinquina, Evgenii O. Tretiakov, Predrag Kalaba, Alán Alpár, Daniela Calvigioni , et al. · 2025

Neuronal morphogenesis relies on intercellular signaling. Astrocytes release metabolites, trophic, and guidance factors to promote neuronal maturation. In contrast, the mechanisms by which astrocytes could limit and stabilize neuronal conn…

A striosomal accumbens pathway drives compulsive seeking behaviors through an aversive Esr1+ hypothalamic-habenula circuit Open

Thomas Contesse, Buse Yel Bektash, Marta Graziano, Chiara Forastieri, Alessandro Contestabile , et al. · 2024

The lateral hypothalamic area (LHA) integrates external stimuli with internal states to drive the choice between competing innate or value-driven motivated behaviors. Projections from the LHA to the lateral habenula (LHb) shape internal st…

All-optical voltage imaging-guided postsynaptic single-cell transcriptome profiling with Voltage-Seq Open

Veronika Csillag, J. C. Noble, Daniela Calvigioni, Björn Reinius, János Fuzik · 2024

Neuronal pathways recruit large postsynaptic populations and maintain connections via distinct postsynaptic response types (PRTs). Until recently, PRTs were accessible as a selection criterion for single-cell RNA sequencing only through pr…

All-optical voltage imaging-guided postsynaptic single-cell transcriptome profiling with Voltage-Seq Open

Veronika Csillag, J. C. Noble, Daniela Calvigioni, Björn Reinius, János Fuzik · 2023

Neuronal pathways recruit large postsynaptic populations and maintain connections via distinct postsynaptic response types (PRTs). Until recently, PRTs were only accessible as a selection criterion for single-cell RNA-sequencing (scRNA-seq…

Evolutionary conservation of hippocampal mossy fiber synapse properties Open

Kenneth A. Pelkey, Geoffrey Vargish, Leonardo V. Pellegrini, Daniela Calvigioni, Julio I. Chapeton , et al. · 2023

Astrocytes modulate neuronal development by S100A6 signaling Open

Valentina Cinquina, Alán Alpár, Predrag Kalaba, Daniela Calvigioni, Evgenii O. Tretiakov , et al. · 2023

Neuronal morphogenesis relies on intercellular signaling. Astrocytes release metabolites, trophic, and guidance factors to promote neuronal maturation. In contrast, the mechanisms by which astrocytes could limit and stabilize neuronal conn…

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum Open

Krishnakanth Kondabolu, Natalie M. Doig, Olaoluwa Ayeko, Bakhtawer Khan, Alexandra Torres , et al. · 2023

The striatum and subthalamic nucleus (STN) are considered to be the primary input nuclei of the basal ganglia. Projection neurons of both striatum and STN can extensively interact with other basal ganglia nuclei, and there is growing anato…

Esr1+ hypothalamic-habenula neurons shape aversive states Open

Daniela Calvigioni, János Fuzik, Pierre Le Merre, Marina Slashcheva, Felix Jung , et al. · 2023

Of Mice and Men: Evolutionary Conservation of Detonator Synapse Properties Open

Kenneth A. Pelkey, Geoffrey Vargish, Leonardo Pellegrini, Daniela Calvigioni, Julio I. Chapeton , et al. · 2023

Esr1+ hypothalamic-habenula neurons shape aversive states Open

Daniela Calvigioni, János Fuzik, Pierre Le Merre, Marina Slashcheva, Felix Jung , et al. · 2022

Excitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) drive aversive responses. We used Patch-seq guided multimodal classification to define the structural and functional heterogeneity of the LHA-LHb…

Complete representation of action space and value in all dorsal striatal pathways Open

Moritz Weglage, Emil Wärnberg, Iakovos Lazaridis, Daniela Calvigioni, Ourania Tzortzi , et al. · 2021

The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-sp…

A selective projection from the subthalamic nucleus to parvalbumin-expressing interneurons of the striatum Open

Krishnakanth Kondabolu, Natalie M. Doig, Olaoluwa Ayeko, Bakhtawer Khan, Alexandra Torres , et al. · 2020

The striatum and subthalamic nucleus (STN) are considered to be the primary input nuclei of the basal ganglia. Projection neurons of both striatum and STN can extensively interact with other basal ganglia nuclei, and there is growing anato…

Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development Open

Johannes Beiersdorf, Zsófia Hevesi, Daniela Calvigioni, Jakob Pyszkowski, Roman A. Romanov , et al. · 2020

Ongoing societal changes in views on the medical and recreational roles of cannabis increased the use of concentrated plant extracts with a Δ9-tetrahydrocannabinol (THC) content of more than 90%. Even though prenatal THC exposure is widely…

Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells Open

Ramesh Chittajallu, Kurt Auville, Vivek Mahadevan, Mandy Lai, Steven Hunt , et al. · 2020

The ability to modulate the efficacy of synaptic communication between neurons constitutes an essential property critical for normal brain function. Animal models have proved invaluable in revealing a wealth of diverse cellular mechanisms …

Author response: Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells Open

Ramesh Chittajallu, Kurt Auville, Vivek Mahadevan, Mandy Lai, Steven Hunt , et al. · 2020

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The ability to modulate the efficacy of sy…

Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells Open

Ramesh Chittajallu, Kurt Auville, Vivek Mahadevan, Massimo Lai, Steven Hunt , et al. · 2020

The ability to modulate the efficacy of synaptic communication between neurons constitutes an essential property critical for normal brain function. Animal models have proved invaluable in revealing a wealth of diverse cellular mechanisms …

Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons Open

Kenneth A. Pelkey, Daniela Calvigioni, Calvin Fang, Geoffrey Vargish, Tyler G. Ekins , et al. · 2020

In violation of Dale’s principle several neuronal subtypes utilize more than one classical neurotransmitter. Molecular identification of vesicular glutamate transporter three and cholecystokinin expressing cortical interneurons (CCK+VGluT3…

Author response: Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons Open

Kenneth A. Pelkey, Daniela Calvigioni, Calvin Fang, Geoffrey Vargish, Tyler G. Ekins , et al. · 2020

A Spatiomolecular Map of the Striatum Open

Antje Märtin, Daniela Calvigioni, Ourania Tzortzi, János Fuzik, Emil Wärnberg , et al. · 2019

Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy Open

Valentina Cinquina, Daniela Calvigioni, Matthias Farlik, Florian Halbritter, Victoria Fife , et al. · 2019

A Spatiomolecular Map of the Striatum Open

Antje Märtin, Daniela Calvigioni, Ourania Tzortzi, János Fuzik, Emil Wärnberg , et al. · 2019

SUMMARY The striatum is organized into two major outputs formed by striatal projection neuron (SPN) subtypes with distinct molecular identities. In addition, the histochemical division into patch and matrix compartments represents an addit…

Neocortical Projection Neurons Instruct Inhibitory Interneuron Circuit Development in a Lineage-Dependent Manner Open

Jason C. Wester, Vivek Mahadevan, Christopher T. Rhodes, Daniela Calvigioni, Sanan Venkatesh , et al. · 2019

Molecular determinants of endocannabinoid-mediated brain development Open

Daniela Calvigioni · 2017

The enchanting process of brain development entails a fragile and finite time window, throughout which biochemical imbalances and external insults can potentially affect developing neuronal circuits. Within the numerous exquisitely orchest…

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes Open

Roman A. Romanov, Amit Zeisel, Joanne Bakker, Fatima Girach, Arash Hellysaz , et al. · 2016

Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex Open

Daniela Calvigioni, Zoltán Máté, János Fuzik, Fatima Girach, Mingdong Zhang , et al. · 2016

Although extensively studied postnatally, the functional differentiation of cholecystokinin (CCK)-containing interneurons en route towards the cerebral cortex during fetal development is incompletely understood. Here, we used CCKBAC/DsRed …

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes Open

János Fuzik, Amit Zeisel, Zoltán Máté, Daniela Calvigioni, Yuchio Yanagawa , et al. · 2015

Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture Open

Katarzyna Maleńczyk, Erik Keimpema, Fabiana Piscitelli, Daniela Calvigioni, Peyman Björklund , et al. · 2015

Significance Glucagon and insulin are produced in distinct cell populations within pancreatic Langerhans islets, where intercellular interactions control their production and release. Modifications to the microstructure of pancreatic islet…

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