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View article: Lomitapide-induced fatty liver is a reversible condition: Evidence from a case of familial chylomicronemia syndrome
Lomitapide-induced fatty liver is a reversible condition: Evidence from a case of familial chylomicronemia syndrome Open
Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder characterized by severe hypertriglyceridemia. It is caused by loss-of-function variants in the genes encoding the lipoprotein lipase (LPL) enzyme and its cofact…
View article: Renal Safety Assessment of Lipid-Lowering Drugs: Between Old Certainties and New Questions
Renal Safety Assessment of Lipid-Lowering Drugs: Between Old Certainties and New Questions Open
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Quantitative and qualitative changes in plasma lipoprotein profiles are frequently associated with CKD and represen…
View article: Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events
Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events Open
Background Familial hypercholesterolemia (FH) may arise from deleterious monogenic variants in FH‐causing genes as well as from a polygenic cause. We evaluated the relationships between monogenic FH and polygenic hypercholesterolemia in in…