Daniela Esser
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View article: Comorbidities and Their Influence on Outcomes and Infectious Complications in Autoimmune Encephalitis
Comorbidities and Their Influence on Outcomes and Infectious Complications in Autoimmune Encephalitis Open
As premorbid psychiatric conditions are main factors associated with unfavorable outcomes, these patients would highly benefit from integrated interdisciplinary treatment centers, or at least heightened awareness of these factors. Concomit…
View article: CSF single-cell RNA sequencing reveals clonally expanded CD4<sup>+</sup>stem cell-like memory T cells in GAD65-antibody associated neurological syndromes
CSF single-cell RNA sequencing reveals clonally expanded CD4<sup>+</sup>stem cell-like memory T cells in GAD65-antibody associated neurological syndromes Open
Background Glutamic acid decarboxylase (GAD) antibody-associated autoimmune neurological syndromes (AINS) are a spectrum of autoimmune-mediated CNS disorders. While antibodies targeting the 65 kDa isoform of GAD are of high diagnostic valu…
View article: Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice
Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice Open
Aging is accompanied by considerable changes in the gut microbiome, yet the molecular mechanisms driving aging and the role of the microbiome remain unclear. Here we combined metagenomics, transcriptomics and metabolomics from aging mice w…
View article: Activated αβ T and reduced mucosa-associated invariant T cells in LGI1- and CASPR2-encephalitis
Activated αβ T and reduced mucosa-associated invariant T cells in LGI1- and CASPR2-encephalitis Open
Anti-leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) autoimmune encephalitis (AIE) are common and characterized by pathogenic antibodies targeting neuronal autoantigens. However, the drivers of the…
View article: Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases
Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases Open
Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in human AIDs with defined autoantigens by combining human leukocy…
View article: Different pain phenotypes are associated with anti-Caspr2 autoantibodies
Different pain phenotypes are associated with anti-Caspr2 autoantibodies Open
View article: CSF plasma cell expansion in LGI1-/CASPR2-autoimmune encephalitis is associated with loss of regulatory MAIT cells
CSF plasma cell expansion in LGI1-/CASPR2-autoimmune encephalitis is associated with loss of regulatory MAIT cells Open
Anti-Leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) associated autoimmune encephalitis (AIE) variants are characterized by directly pathogenic autoantibodies present in serum and CSF. The dynamics…
View article: Recurrent Phases of Strict Protein Limitation Inhibit Tumor Growth and Restore Lifespan in A <i>Drosophila</i> Intestinal Cancer Model
Recurrent Phases of Strict Protein Limitation Inhibit Tumor Growth and Restore Lifespan in A <i>Drosophila</i> Intestinal Cancer Model Open
Diets that restrict caloric or protein intake offer a variety of benefits, including decreasing the incidence of cancer. However, whether such diets pose a substantial therapeutic benefit as auxiliary cancer treatments remains unclear. We …
View article: Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models Open
Introduction Resistance in anti-cancer treatment is a result of clonal evolution and clonal selection. In chronic myeloid leukemia (CML), the hematopoietic neoplasm is predominantly caused by the formation of the BCR::ABL1 kinase. Evidentl…
View article: Insights into Gene Regulation under Temozolomide-Promoted Cellular Dormancy and Its Connection to Stemness in Human Glioblastoma
Insights into Gene Regulation under Temozolomide-Promoted Cellular Dormancy and Its Connection to Stemness in Human Glioblastoma Open
The aggressive features of glioblastoma (GBM) are associated with dormancy. Our previous transcriptome analysis revealed that several genes were regulated during temozolomide (TMZ)-promoted dormancy in GBM. Focusing on genes involved in ca…
View article: Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a<i>Drosophila</i>intestinal cancer model
Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a<i>Drosophila</i>intestinal cancer model Open
Diets that restrict caloric or protein intake offer a variety of benefits, including decreasing the incidence of cancer. However, whether such diets pose a substantial therapeutic benefit as auxiliary cancer treatments remains unclear. We …
View article: Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis
Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis Open
Autoimmune Encephalitis (AE) spans a group of non-infectious inflammatory conditions of the central nervous system due to an imbalanced immune response. Aiming to elucidate the pathophysiological mechanisms of AE, we applied an unsupervise…
View article: B-cell-depletion reverses dysbiosis of the microbiome in multiple sclerosis patients
B-cell-depletion reverses dysbiosis of the microbiome in multiple sclerosis patients Open
To elucidate cross-sectional patterns and longitudinal changes of oral and stool microbiota in multiple sclerosis (MS) patients and the effect of B-cell depletion. We conducted an observational, longitudinal clinical cohort study analysing…
View article: B-Cell-Depletion Reverses Dysbiosis of the Microbiome in Multiple Sclerosis Patients
B-Cell-Depletion Reverses Dysbiosis of the Microbiome in Multiple Sclerosis Patients Open
Objective: To elucidate cross-sectional patterns and longitudinal changes of oral and stool microbiota in multiple sclerosis (MS) patients and the effect of B-cell depletion.Methods: We conducted an observational, longitudinal clinical coh…
View article: Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19
Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19 Open
View article: Pre-existing T cell memory as a risk factor for severe COVID-19 in the elderly
Pre-existing T cell memory as a risk factor for severe COVID-19 in the elderly Open
Summary Coronavirus disease 2019 (COVID-19) displays high clinical variability but the parameters that determine disease severity are still unclear. Pre-existing T cell memory has been hypothesized as a protective mechanism but conclusive …
View article: Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy Open
View article: Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly Open
The original version of this Article contained an error in the spelling of the author Jule Müller, which was incorrectly given as Julia Müller. Additionally, in Fig. 4a, the blue-red colour scale for fold change in ageing/disease regulatio…
View article: Genomic and transcriptomic signatures of inflammation and malignancy in the intestinal tract
Genomic and transcriptomic signatures of inflammation and malignancy in the intestinal tract Open
Cancer is one of the main causes of death in industrialized countries. A better understanding of genomic mechanisms underlying tumor development would create novel treatment possibilities. In the present study, methods based on next-genera…
View article: Functions of the Microbiota for the Physiology of Animal Metaorganisms
Functions of the Microbiota for the Physiology of Animal Metaorganisms Open
Animals are usually regarded as independent entities within their respective environments. However, within an organism, eukaryotes and prokaryotes interact dynamically to form the so-called metaorganism or holobiont, where each partner ful…
View article: Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice Open
View article: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly Open
View article: Interpreting whole genome and exome sequencing data of individual gastric cancer samples
Interpreting whole genome and exome sequencing data of individual gastric cancer samples Open
View article: Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae
Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae Open
View article: Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae
Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae Open
Lists of all differentially expressed genes in the different priming-challenge treatments (compared to the fully naïve control; xlsx file). Relevant columns include the following: sample_1 and sample_2 – treatment groups being compared; No…
View article: Additional file 5: Table S3. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae
Additional file 5: Table S3. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae Open
Lists of top 20 overrepresented GO terms in Btt exposed treatment groups (compared to fully naïve control). Methodology as described for Fig. 7. The columns are as follows: GO ID – Gene Ontology unique ID of the overrepresented GO term; GO…
View article: Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease
Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease Open
Objective An inadequate host response to the intestinal microbiota likely contributes to the manifestation and progression of human inflammatory bowel disease (IBD). However, molecular approaches to unravelling the nature of the defective …
View article: Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis
Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis Open
Pathogen infection can activate multiple signaling cascades that ultimately alter the abundance of molecules in cells. This change can be measured both at the transcript and protein level. Studies analyzing the immune response at both leve…