Explanipedia

Compartmentalized VEGF Receptor Expression in Hypothalamic Tanycytes Reveals a Novel Non- Endothelial Axis of VEGF Signaling (Tanycytes as a Novel Non-Endothelial Target of VEGF Signaling) Open

Ombeline Desruelle, Manon Leclerc, Sreekala S. Nampoothiri, Daniela Fernandois, Claude‐Alain Maurage , et al. · 2025

Background: Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are critical regulators of angiogenesis and vascular homeostasis. While VEGF signaling has been extensively studied in endothelial cells, emerging evidenc…

Hypothalamic gliosis as a potential mediator of improved glucose tolerance induced by time-restricted feeding in obese mice Open

Camila Astudillo-Guerrero, Daniela Fernandois, Émilie Caron, Vincent Prévot, Joshua P. Thaler , et al. · 2025

This study shows that time-restricted feeding (TRF) improves glucose tolerance in obese mice independently of weight loss. Surprisingly, this benefit is linked to increased hypothalamic gliosis, challenging the view that gliosis is solely …

Metabolic control of ovarian function through the sympathetic nervous system: role of leptin Open

Camila Astudillo-Guerrero, Alfonso Paredes, Jorge Escobar, Daniela Fernandois, Rafael Barra , et al. · 2025

The link between metabolism and reproduction is well-known. Both undernutrition and obesity affect the reproductive system. Metabolic status influences reproductive physiology by regulating gonadotropin secretion and affecting reproductive…

Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus Open

Soma Szentkirályi-Tóth, Balázs Göcz, Szabolcs Takács, Miklós Sárvári, Imre Farkas , et al. · 2025

While hypothalamic kisspeptin (KP) neurons play well-established roles in the estrogen-dependent regulation of reproduction, little is known about extrahypothalamic KP-producing (KP LS ) neurons of the lateral septum. As established previo…

Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism Open

Daniela Fernandois, Mariam Rusidzé, Helge Müller‐Fielitz, Florent Sauvé, Eleonora Deligia , et al. · 2024

Our investigation reveals that tanycytes, specialized glial cells in the brain, are key interpreters of estrogen signals for orexigenic NPY neurons in the hypothalamus. Disrupting tanycytic estrogen receptors not only alters fertility in f…

Multi-Organ Increase in Norepinephrine Levels after Central Leptin Administration and Diet-Induced Obesity Open

Daniela Fernandois, María J. Vázquez, Alexia Barroso, Alfonso Paredes, Manuel Tena‐Sempere , et al. · 2023

Autonomic innervation is important to regulate homeostasis in every organ of the body. The sympathetic nervous system controls several organs associated with metabolism and reproduction, including adipose tissue, the liver, and the ovaries…

ESTRADIOL-MEDIATED ACTIVATION OF ESTROGEN RECEPTOR ALPHA IN TANYCYTES MODULATES ENERGY HOMEOSTASIS AND LEPTIN TRANSPORT INTO THE HYPOTHALAMUS. Open

Daniela Fernandois, Eleonora Deligia, Florent Sauvé, Mónica Imbernón, Inés Martínez‐Corral , et al. · 2023

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death Open

Florent Sauvé, Sreekala S. Nampoothiri, Sophie Clarke, Daniela Fernandois, Caio Fernando Ferreira Coêlho , et al. · 2023

Summary Background We have recently demonstrated a causal link between loss of gonadotropin-releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive deficits during pathological aging, including Down syndrome an…

Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions Open

Mónica Imbernón, Chiara Saponaro, Hans Christian Cederberg Helms, Manon Duquenne, Daniela Fernandois , et al. · 2022

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels Open

Erika Cecon, Daniela Fernandois, Nicolas Renault, Caio Fernando Ferreira Coêlho, Jan Wenzel , et al. · 2022

Sowing SARS-CoV-2 to reap neurodegeneration: A hamster study Open

Sowmyalakshmí Rasika, Daniela Fernandois, Vincent Prévot · 2022

The jury is still out on how widespread brain infection by SARS-CoV-2 is, and what invasion route or routes the virus takes. However, more and more reports suggest that even patients who contract mild forms of COVID-19 suffer from long-ter…

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels Open

Erika Cecon, Daniela Fernandois, Nicolas Renault, Caio Fernando Ferreira Coêlho, Jan Wenzel , et al. · 2022

COVID-19 is a complex disease with short- and long-term respiratory, inflammatory and neurological symptoms that are triggered by the infection with SARS-CoV-2. Invasion of the brain by SARS-CoV-2 has been observed in humans and is postula…

SARS-CoV-2 infects human GnRH neurons and tanycytes, disrupting hypothalamic-pituitary hormonal axes Open

Florent Sauvé, Sreekala S. Nampoothiri, Daniela Fernandois, Caio Fernando Ferreira Coêlho, Julie Dam , et al. · 2021

Neuroinvasion by SARS-CoV-2 is now accepted. To investigate whether low testosterone levels observed in men with severe COVID-19 could be of central origin, we retrospectively analyzed blood samples from 60 male intensive-care patients and…

Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function Open

Manon Duquenne, Cintia Folgueira, Cyril Bourouh, M Millet, Anisia Silva , et al. · 2021

Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons Open

Tori Lhomme, Jérôme Clasadonte, Mónica Imbernón, Daniela Fernandois, Florent Sauvé , et al. · 2021

Hypothalamic glucose sensing enables an organism to match energy expenditure and food intake to circulating levels of glucose, the main energy source of the brain. Here, we established that tanycytes of the arcuate nucleus of the hypothala…

Hypothalamic bile acid-TGR5 signaling protects from obesity Open

Ashley Castellanos-Jankiewicz, Omar Guzmán‐Quevedo, Valérie S. Fénelon, Philippe Zizzari, Carmelo Quarta , et al. · 2021

Perinatal nutrition and metabolic disease Open

Gonzalo Cruz, Daniela Fernandois, Gonzalo Jorquera, Paola Llanos, Manuel Maliqueo , et al. · 2020

With the worldwide increase in overnutrition rates, maternal obesity during pregnancy has also increased. This condition is related to increasing incidence of pregnancy and delivery complications, and it is associated to long-term vulnerab…

Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty Open

Violeta Heras, Juan M. Castellano, Daniela Fernandois, Inmaculada Velasco, Elvira Rodríguez-Vázquez , et al. · 2020

Prenatal metformin treatment improves ovarian function in offspring of obese rats Open

Daniela Álvarez, Karina Ceballo, Sofía Olguín, Jonathan Martínez-Pinto, Manuel Maliqueo , et al. · 2018

Maternal obesity causes a wide range of impairment in offspring, such as metabolic and reproductive dysfunctions. We previously demonstrated that female offspring of obese rats have increased serum estradiol levels during early postnatal l…

Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways Open

Miguel A. Sánchez-Garrido, Francisco Ruíz-Pino, Inmaculada Velasco, Alexia Barroso, Daniela Fernandois , et al. · 2017

Obesity and its comorbidities are reaching epidemic proportions worldwide. Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance. This intergenerational transmission has also bee…

Effects of sympathectomy on ovarian follicular development and steroid secretion Open

Maritza P. Garrido, Daniela Fernandois, Mauricio Venegas, Alfonso Paredes · 2017

Recently, the influence of adrenergic activity over ovarian function, and thus fertility, has begun to gain importance. Previous studies have shown that adrenergic activity through norepinephrine (NE) participates in the control of follicu…

Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system Open

Daniela Fernandois, Gonzalo Cruz, Eun Kyung Na, Hernán E. Lara, Alfonso Paredes · 2016

Previous work has demonstrated that the increase in the activity of sympathetic nerves, which occurs during the subfertility period in female rats, causes an increase in follicular cyst development and impairs follicular development. In ad…

Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation Open

Gonzalo Cruz, Daniela Fernandois, Alfonso Paredes · 2016

Successful reproduction is the result of a myriad interactions in which the ovary and the ovarian follicular reserve play a fundamental role. At present, women who delay maternity until after 30 years of age have a decreased fertility rate…

Correction: Corrigendum: Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function Open

Silvia León, Daniela Fernandois, Alexandra Sull, Judith Sull, Michele D. Calder , et al. · 2016

Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function Open

Silvia León, Daniela Fernandois, Alexandra Sull, Judith Sull, Michele D. Calder , et al. · 2016

Prenatal metformin treatment prevents estradiol increase and partially improves ovarian function in offspring of obese mothers Open

Daniela Álvarez, Sofía Olguín, Karina Ceballo, Jonathan Martinez, Tania Cerda , et al. · 2016

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood Open

Valery Ambrosetti, Marcelo Guerra, Luisa Ramirez, Aldo Reyes, Daniela Álvarez , et al. · 2016

Maternal obesity during pregnancy has been related with several pathological states in offspring. However, the impact of maternal obesity on reproductive system on the progeny is beginning to be elucidated. In this work, we characterize th…

Kisspeptin is involved in ovarian follicular development during aging in rats Open

Daniela Fernandois, Erqian Na, Francisco Cuevas, Gonzalo Cruz, Hernán E. Lara , et al. · 2015

We have previously reported that kisspeptin (KP) may be under the control of the sympathetic innervation of the ovary. Considering that the sympathetic activity of the ovary increases with aging, it is possible that ovarian KP also increas…

Maternal obesity in pregnant rats is associated to increased levels of oestradiol during early postnatal life and altered ovarian follicular development in the offspring Open

Aldo Reyes, Luisa Ramirez, Valery Ambrosetti, Marcelo Guerra, Daniela Álvarez , et al. · 2015

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

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