Daniela Flück
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View article: Blood pressure response to exposure to moderate altitude in patients with COPD
Blood pressure response to exposure to moderate altitude in patients with COPD Open
Esther I Schwarz,1 Tsogyal D Latshang,1 Michael Furian,1 Deborah Flück,1 Sebastian Segitz,1 Severine Müller-Mottet,1 Silvia Ulrich,1 Konrad E Bloch,1,2 Malcolm Kohler1,2 1Department of Pulmonology and Sleep Disorders Centre, University Hos…
View article: Carotid chemoreceptor control of muscle sympathetic nerve activity in hypobaric hypoxia
Carotid chemoreceptor control of muscle sympathetic nerve activity in hypobaric hypoxia Open
New Findings What is the central question of this study? High‐altitude hypoxia increases muscle sympathetic nerve activity (MSNA), but whether intravenous infusion of dopamine, to blunt the responsiveness of the carotid chemoreceptors, red…
View article: Cerebrovascular and ventilatory responses to acute normobaric hypoxia in girls and women
Cerebrovascular and ventilatory responses to acute normobaric hypoxia in girls and women Open
Physiological responses to hypoxia in children are incompletely understood. We aimed to characterize cerebrovascular and ventilatory responses to normobaric hypoxia in girls and women. Ten healthy girls (9.9 ± 1.7 years; mean ± SD; Tanner …
View article: One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia
One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia Open
New Findings What is the central question of this study? It is suggested that remote ischemic preconditioning (RIPC) might offer protection against ischaemia–reperfusion injuries, but the utility of RIPC in high‐altitude settings remains u…
View article: Extra- and intracranial blood flow regulation during the cold pressor test: influence of age
Extra- and intracranial blood flow regulation during the cold pressor test: influence of age Open
We determined how the extra- and intracranial circulations respond to generalized sympathetic activation evoked by a cold pressor test (CPT) and whether this is affected by healthy aging. Ten young [23 ± 2 yr (means ± SD)] and nine older (…
View article: UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level
UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level Open
Developmental cerebral hemodynamic adaptations to chronic high-altitude exposure, such as in the Sherpa population, are largely unknown. To examine hemodynamic adaptations in the developing human brain, we assessed common carotid (CCA), in…
View article: Passive heat stress reduces circulating endothelial and platelet microparticles
Passive heat stress reduces circulating endothelial and platelet microparticles Open
New Findings What is the central question of this study? Does passive heat stress of +2°C oesophageal temperature change concentrations of circulating arterial endothelial‐ and platelet‐derived microparticles in healthy adults? What is the…
View article: Adenosine receptor-dependent signaling is not obligatory for normobaric and hypobaric hypoxia-induced cerebral vasodilation in humans
Adenosine receptor-dependent signaling is not obligatory for normobaric and hypobaric hypoxia-induced cerebral vasodilation in humans Open
Hypoxia increases cerebral blood flow (CBF) with the underlying signaling processes potentially including adenosine. A randomized, double-blinded, and placebo-controlled design, was implemented to determine if adenosine receptor antagonism…
View article: Parasympathetic withdrawal increases heart rate after 2 weeks at 3454 m altitude
Parasympathetic withdrawal increases heart rate after 2 weeks at 3454 m altitude Open
Key points Heart rate is increased in chronic hypoxia and we tested whether this is the result of increased sympathetic nervous activity, reduced parasympathetic nervous activity, or a non‐autonomic mechanism. In seven lowlanders, heart ra…
View article: Cerebrovascular reactivity in the developing brain: influence of sex and maturation
Cerebrovascular reactivity in the developing brain: influence of sex and maturation Open
The brain is energetically expensive and maintenance of normal cerebral metabolism is critically dependent on the regulation of cerebral blood flow (CBF). In addition to buffering changes in blood pressure and meeting local metabolic needs…