Daniela Foti
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View article: Gestational Diabetes Risk May Vary Depending on Birth Month
Gestational Diabetes Risk May Vary Depending on Birth Month Open
Background/Objectives: Prenatal environmental exposure may influence disease risk later in life. Previous studies suggest that season or month of birth affects susceptibility to various conditions, including type 2 diabetes. We aimed to ev…
View article: Obesity Is Associated with Larger Thyroid Nodules but Not with Malignant Cytology
Obesity Is Associated with Larger Thyroid Nodules but Not with Malignant Cytology Open
Background: Obesity has been proposed as a risk factor for differentiated thyroid carcinoma (DTC), though findings in the literature remain conflicting. While some studies suggest an association between elevated body mass index (BMI) and t…
View article: #2747 MOTS-c Levels and sarcopenia risk in patients on chronic peritoneal dialysis: a pilot study
#2747 MOTS-c Levels and sarcopenia risk in patients on chronic peritoneal dialysis: a pilot study Open
Background and Aims Sarcopenia is a common and debilitating condition in patients with end-stage kidney disease (ESKD) undergoing peritoneal dialysis (PD). Its development is influenced by multiple factors, including mitochondrial dysfunct…
View article: SUN-696 Thrombospondin-1 in Severe Obesity: a Hypoxia-Suppressed Cardiometabolic Biomarker Interacting with Endothelin-1
SUN-696 Thrombospondin-1 in Severe Obesity: a Hypoxia-Suppressed Cardiometabolic Biomarker Interacting with Endothelin-1 Open
Disclosure: M. Mirabelli: None. M. Greco: None. F.S. Brunetti: None. E. Chiefari: None. D.P. Foti: None. A. Brunetti: None. Background: Thrombospondin-1 (TSP1) is a multimeric glycoprotein mainly stored in platelet (PLT) granules but also …
View article: MON-568 HMGA1 Deficiency Ties Insulin Resistance to Tau-Related Neurodegeneration
MON-568 HMGA1 Deficiency Ties Insulin Resistance to Tau-Related Neurodegeneration Open
Disclosure: M. Mirabelli: None. F.S. Brunetti: None. E. Chiefari: None. D.P. Foti: None. A. Brunetti: None. Background: Growing evidence links tau-related neurodegeneration, a hallmark of Alzheimer's disease (AD) and other tauopathies, to …
View article: Predicting accelerated fetal growth in pregnancy: beyond maternal hyperglycemia – The role of prothymosin-α, inflammatory cytokines, and angiogenic factors
Predicting accelerated fetal growth in pregnancy: beyond maternal hyperglycemia – The role of prothymosin-α, inflammatory cytokines, and angiogenic factors Open
View article: HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance
HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance Open
View article: Circulating Thrombospondin-1 and Endothelin-1 Levels Tend to Decline with Increasing Obesity Severity in Women: Evidence from a Pilot, Cross-Sectional Study
Circulating Thrombospondin-1 and Endothelin-1 Levels Tend to Decline with Increasing Obesity Severity in Women: Evidence from a Pilot, Cross-Sectional Study Open
Background: Thrombospondin-1 (TSP1) is a multimeric glycoprotein that is increasingly recognized as a mediator of metabolic, thrombotic, and inflammatory processes. Although TSP1 expression has been associated with adipose tissue dysfuncti…
View article: MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study
MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study Open
Background and Objectives: Sarcopenia is exceedingly frequent in end-stage kidney disease (ESKD) patients on dialysis, including those undergoing peritoneal dialysis (PD), and is of multifactorial origin. MOTS-c is a mitochondrial-derived …
View article: Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD
Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD Open
Background Chronic kidney disease (CKD) has now reached pandemic proportions but risk prediction towards end-stage kidney disease (ESKD) remains challenging. Kidney fibrosis is a key determinant in the transition from CKD to ESKD. In this …
View article: Circulating Autoantibodies in Adults with Hashimoto’s Thyroiditis: New Insights from a Single-Center, Cross-Sectional Study
Circulating Autoantibodies in Adults with Hashimoto’s Thyroiditis: New Insights from a Single-Center, Cross-Sectional Study Open
Background: Hashimoto’s thyroiditis (HT) is a common autoimmune thyroid disorder characterized by elevated anti-thyroid peroxidase (A-TPO) antibodies. HT frequently coexists with other autoimmune conditions, which are marked by organ-speci…
View article: Hypoxia in Human Obesity: New Insights from Inflammation towards Insulin Resistance—A Narrative Review
Hypoxia in Human Obesity: New Insights from Inflammation towards Insulin Resistance—A Narrative Review Open
Insulin resistance (IR), marked by reduced cellular responsiveness to insulin, and obesity, defined by the excessive accumulation of adipose tissue, are two intertwined conditions that significantly contribute to the global burden of cardi…
View article: Clinical Risk Factors and First Gestational 75 g OGTT May Predict Recurrent and New-Onset Gestational Diabetes in Multiparous Women
Clinical Risk Factors and First Gestational 75 g OGTT May Predict Recurrent and New-Onset Gestational Diabetes in Multiparous Women Open
Background: Women who experience gestational diabetes mellitus (GDM) during their first pregnancy are at a high risk of developing GDM again in subsequent pregnancies. Even mothers with no previous history of GDM may develop the condition …
View article: Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study
Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study Open
Background Mortality and cardiovascular (CV) risk prediction in individuals with end-stage kidney disease (ESKD) on chronic hemodialysis (HD) remains challenging due to the multitude of implicated factors. In a multicenter ESKD-HD cohort, …
View article: Editorial: Transcriptional regulation of glucose metabolism: gaps and controversies, volume II
Editorial: Transcriptional regulation of glucose metabolism: gaps and controversies, volume II Open
Keywords: glucose homeostasis, gene transcription, insulin resistance, insulin signaling, transcription factors
View article: Urinary Post-Translationally Modified Fetuin-A (uPTM-FetA) in Chronic Kidney Disease Patients with and without Diabetic Kidney Disease
Urinary Post-Translationally Modified Fetuin-A (uPTM-FetA) in Chronic Kidney Disease Patients with and without Diabetic Kidney Disease Open
Background and Objectives: A novel post-translational modification (PTM) fragment derived from the cleavage of Fetuin-A (PTM-FetA) has recently emerged as a sensitive biomarker for kidney damage in diabetic patients, but evidence in other …
View article: Incidental thyroid carcinoma in an endemic goiter area in Italy: histopathological features and predictors of a common finding
Incidental thyroid carcinoma in an endemic goiter area in Italy: histopathological features and predictors of a common finding Open
Purpose The occurrence and histopathological features of incidental thyroid carcinoma (ITC) vary considerably among populations from different geographical regions. The aim of this study is to assess the prevalence and histopathological ch…
View article: Coexistence of Hashimoto’s Thyroiditis in Differentiated Thyroid Cancer: Post-Operative Monitoring of Anti-Thyroglobulin Antibodies and Assessment of Treatment Response
Coexistence of Hashimoto’s Thyroiditis in Differentiated Thyroid Cancer: Post-Operative Monitoring of Anti-Thyroglobulin Antibodies and Assessment of Treatment Response Open
Introduction: Differentiated thyroid carcinoma (DTC) is frequently found in conjunction with autoimmune thyroid disorders, particularly Hashimoto’s thyroiditis (HT). This study investigates the impact of coexisting HT on the persistence of…
View article: Circulating miRNA 122-5p Expression Predicts Mortality and Cardiovascular Events in Chronic Hemodialysis Patients: A Multicentric, Pilot, Prospective Study
Circulating miRNA 122-5p Expression Predicts Mortality and Cardiovascular Events in Chronic Hemodialysis Patients: A Multicentric, Pilot, Prospective Study Open
Background: Despite patients undergoing chronic hemodialysis (HD) being notoriously prone to adverse cardiovascular (CV) events, risk prediction in this population remains challenging. miRNA 122-5p, a short, non-coding RNA predominantly in…
View article: Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series
Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has generated an unprecedented challenge for healthcare systems worldwide. Currently, the scientific community wonders if liver injury in patients suffering from sev…
View article: Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question
Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question Open
In recent years, there has been a dramatic increase in the number of pregnancies complicated by gestational diabetes mellitus (GDM). GDM occurs when maternal insulin resistance develops and/or progresses during gestation, and it is not com…
View article: In Vitro Evaluation of Ferutinin Rich-Ferula communis L., ssp. glauca, Root Extract on Doxorubicin-Induced Cardiotoxicity: Antioxidant Properties and Cell Cycle Modulation
In Vitro Evaluation of Ferutinin Rich-Ferula communis L., ssp. glauca, Root Extract on Doxorubicin-Induced Cardiotoxicity: Antioxidant Properties and Cell Cycle Modulation Open
The clinical use of anthracycline Doxorubicin as an antineoplastic drug in cancer therapy is limited by cardiotoxic effects that can lead to congestive heart failure. Recent studies have shown several promising activities of different spec…
View article: Urinary Marinobufagenin in Patients with Non-Advanced Chronic Kidney Disease: A Cross-Sectional Study
Urinary Marinobufagenin in Patients with Non-Advanced Chronic Kidney Disease: A Cross-Sectional Study Open
Background and Objectives: The global prevalence of chronic kidney disease (CKD) is on the rise, posing important challenges for healthcare systems. Thus, the search for new factors potentially involved in the pathogenesis, progression and…
View article: From Euglycemia to Recent Onset of Type 2 Diabetes Mellitus: A Proof-of-Concept Study on Circulating microRNA Profiling Reveals Distinct, and Early microRNA Signatures
From Euglycemia to Recent Onset of Type 2 Diabetes Mellitus: A Proof-of-Concept Study on Circulating microRNA Profiling Reveals Distinct, and Early microRNA Signatures Open
Background and aim—Alterations in circulating microRNA (miRNA) expression patterns are thought to be involved in the early stages of prediabetes, as well as in the progression to overt type 2 diabetes mellitus (T2D) and its vascular compli…
View article: Prothymosin-Alpha, a Novel and Sensitive Biomarker of the Inflammatory and Insulin-Resistant Statuses of Obese Individuals: A Pilot Study Involving Humans
Prothymosin-Alpha, a Novel and Sensitive Biomarker of the Inflammatory and Insulin-Resistant Statuses of Obese Individuals: A Pilot Study Involving Humans Open
Background: Obesity constitutes a chronic, low-grade inflammatory status that predisposes people to the development of insulin resistance and cardiometabolic complications. Hypoxia, a main pathological feature of visceral fat in obese indi…
View article: #3101 LOW CIRCULATING LEVELS OF CARDIO-REGULATORY MIRNAS PREDICT WORSE OUTCOMES IN HEMODIALYSIS PATIENTS
#3101 LOW CIRCULATING LEVELS OF CARDIO-REGULATORY MIRNAS PREDICT WORSE OUTCOMES IN HEMODIALYSIS PATIENTS Open
Background and Aims Patients with end stage renal disease (ESKD) on hemodialysis (HD) have a high risk of cardiovascular (CV) events, this being mostly related to the presence of uraemic cardiomyopathy. A deregulation in the expression of …
View article: #3103 OMENTIN-1 AND SUBCLINICAL ATHEROSCLEROSIS IN ESKD PATIENTS UNDERGOING HEMODIALYSIS AND IN KIDNEY TRANSPLANT RECIPIENTS
#3103 OMENTIN-1 AND SUBCLINICAL ATHEROSCLEROSIS IN ESKD PATIENTS UNDERGOING HEMODIALYSIS AND IN KIDNEY TRANSPLANT RECIPIENTS Open
Background and Aims In end-stage kidney disease (ESKD) patients, atherosclerosis is a key-player for cardiovascular risk, being influenced by endothelial dysfunction, inflammation and mineral dysmetabolism. Omentin-1 is an adipokine involv…
View article: Interleukin-62/lymphocyte as a proposed predictive index for COVID-19 patients treated with monoclonal antibodies
Interleukin-62/lymphocyte as a proposed predictive index for COVID-19 patients treated with monoclonal antibodies Open
In a convenience sample of 93 patients treated with monoclonal antibodies (moAbs) against SARS-CoV-2, the interleukin-6 2 /lymphocyte count ratio (IL-6 2 /LC) was able to predict clinical worsening both in early stages of COVID-19 and in o…
View article: Marinobufagenin, Left Ventricular Hypertrophy and Residual Renal Function in Kidney Transplant Recipients
Marinobufagenin, Left Ventricular Hypertrophy and Residual Renal Function in Kidney Transplant Recipients Open
Background: Left ventricular hypertrophy (LVH), which is a pervasive complication of end-stage kidney disease (ESKD), persists in some uremic individuals even after kidney transplantation (Ktx), contributing to worsening CV outcomes. Marin…
View article: Maternal Preconception Body Mass Index Overtakes Age as a Risk Factor for Gestational Diabetes Mellitus
Maternal Preconception Body Mass Index Overtakes Age as a Risk Factor for Gestational Diabetes Mellitus Open
Introduction—The purpose of this study was to determine the relative impact of modifiable and non-modifiable risk factors in the development of gestational diabetes mellitus (GDM), with a particular focus on maternal preconception body mas…