Daniela Gaebler
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View article: Methods for processing and analyzing images of vascularized micro-organ and tumor systems
Methods for processing and analyzing images of vascularized micro-organ and tumor systems Open
Our group has developed and validated an advanced microfluidic platform to improve preclinical modeling of healthy and disease states, enabling extended culture and detailed analysis of tissue-engineered miniaturized organ constructs, or “…
View article: Methods for Processing and Analyzing Images of Vascularized Micro-Organ and Tumor Systems
Methods for Processing and Analyzing Images of Vascularized Micro-Organ and Tumor Systems Open
Our group has developed and validated an advanced microfluidic platform to improve preclinical modeling of healthy and disease states, enabling extended culture and detailed analysis of tissue-engineered miniaturized organ constructs, or “…
View article: Improving tumor microenvironment assessment in chip systems through next-generation technology integration
Improving tumor microenvironment assessment in chip systems through next-generation technology integration Open
The tumor microenvironment (TME) comprises a diverse array of cells, both cancerous and non-cancerous, including stromal cells and immune cells. Complex interactions among these cells play a central role in driving cancer progression, impa…
View article: Microphysiological systems as models for immunologically ‘cold’ tumors
Microphysiological systems as models for immunologically ‘cold’ tumors Open
The tumor microenvironment (TME) is a diverse milieu of cells including cancerous and non-cancerous cells such as fibroblasts, pericytes, endothelial cells and immune cells. The intricate cellular interactions within the TME hold a central…
View article: Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model Open
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are crucial in TNBC progression; however, understanding the molecular basis of stromal cell acti…
View article: Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research
Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research Open
A lack of validated cancer models that recapitulate the tumor microenvironment of solid cancers in vitro remains a significant bottleneck for preclinical cancer research and therapeutic development. To overcome this problem, we have develo…
View article: Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model Open
Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are crucial in TNBC progression; however, understanding the molecular basis of stromal cell acti…