Daniela Hozbor
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View article: Global Incidence of Pertussis After the COVID-19 Pandemic
Global Incidence of Pertussis After the COVID-19 Pandemic Open
Importance Pertussis, or whooping cough, is caused by the Bordetella pertussis bacterium. It induces prolonged cough in all age groups and is a severe, life-threatening disease in young infants. Observations In an online workshop organized…
View article: Erratum for Carbonetti et al., “Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development”
Erratum for Carbonetti et al., “Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development” Open
Erratum for “Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development”
View article: Harnessing outer membrane vesicles derived from Bordetella pertussis to overcome key limitations of acellular pertussis vaccines
Harnessing outer membrane vesicles derived from Bordetella pertussis to overcome key limitations of acellular pertussis vaccines Open
Acellular pertussis (aP) vaccines have markedly reduced the global burden of severe pertussis. However, their limited ability to elicit mucosal and durable immunity has been linked to waning protection and sustained Bordetella pertussis ci…
View article: Defining the Scientist: A Consensus-Based Approach
Defining the Scientist: A Consensus-Based Approach Open
Introduction The term “scientist” lacks a universally accepted definition, reflecting the evolving, interdisciplinary nature of scientific work and posing challenges for recognition, communication, and policy. This study aims to develop co…
View article: Country-Specific Data and Priorities for Pertussis in Latin America: Recent Findings From the Global Pertussis Initiative
Country-Specific Data and Priorities for Pertussis in Latin America: Recent Findings From the Global Pertussis Initiative Open
In 2023, the Global Pertussis Initiative met to assess the burden of and vaccination policies against pertussis in 10 Latin American countries. Although pertussis is a notifiable disease in the represented countries, poor disease awareness…
View article: A Novel Vaccine for Bovine Diarrhea Complex Utilizing Recombinant Enterotoxigenic Escherichia coli and Salmonella Expressing Surface-Displayed Chimeric Antigens from Enterohemorrhagic Escherichia coli O157:H7
A Novel Vaccine for Bovine Diarrhea Complex Utilizing Recombinant Enterotoxigenic Escherichia coli and Salmonella Expressing Surface-Displayed Chimeric Antigens from Enterohemorrhagic Escherichia coli O157:H7 Open
Background/Objectives: Enterohemorrhagic Escherichia coli (EHEC) O157:H7, a zoonotic pathogen primarily found in cattle, causes Hemolytic Uremic Syndrome (HUS) in humans, often through contaminated food. Its Type Three Secretion System (T3…
View article: Pertussis in Southeast Asia: country-level burden and recommendations from the Global Pertussis Initiative
Pertussis in Southeast Asia: country-level burden and recommendations from the Global Pertussis Initiative Open
The Global Pertussis Initiative met in March 2024 to discuss the burden of pertussis and prevention efforts in six Southeast Asian countries: Cambodia, Indonesia, Malaysia, Singapore, Thailand, and Vietnam. Except for Cambodia, pertussis i…
View article: Mucosal vaccination with outer membrane vesicles derived from Bordetella pertussis reduces nasal bacterial colonization after experimental infection
Mucosal vaccination with outer membrane vesicles derived from Bordetella pertussis reduces nasal bacterial colonization after experimental infection Open
Introduction We previously identified Bordetella pertussis -derived outer membrane vesicles (OMVs) as a promising immunogen for improving pertussis vaccines. In this study, we evaluated the efficacy of our vaccine prototype in immunization…
View article: A Novel Vaccine for Bovine Diarrhea Complex Utilizing Recombinant enterotoxigenic Escherichia coli and Salmonella Expressing Surface-Displayed Chimeric Antigens from Enterohemorrhagic Escherichia coli O157:H7
A Novel Vaccine for Bovine Diarrhea Complex Utilizing Recombinant enterotoxigenic Escherichia coli and Salmonella Expressing Surface-Displayed Chimeric Antigens from Enterohemorrhagic Escherichia coli O157:H7 Open
Enterohemorrhagic Escherichia coli (EHEC) O157:H7, primarily found in cattle, is a zoonotic pathogen associated with Hemolytic Uremic Syndrome (HUS) in humans that is typically transmitted through contaminated food. Among its many virulenc…
View article: Outer membrane vesicles derived from Bordetella pertussis are potent adjuvant that drive Th1-biased response
Outer membrane vesicles derived from Bordetella pertussis are potent adjuvant that drive Th1-biased response Open
For several years, we have been committed to exploring the potential of Bordetella pertussis -derived outer membrane vesicles (OMV Bp ) as a promising third-generation vaccine against the reemerging pertussis disease. The results of our pr…
View article: Use of Mucosally Administered Outer Membrane Vesicles Derived from<i>Bordetella pertussis</i>to Diminish Nasal Bacterial Colonization
Use of Mucosally Administered Outer Membrane Vesicles Derived from<i>Bordetella pertussis</i>to Diminish Nasal Bacterial Colonization Open
Background We previously identified Bordetella pertussis -derived outer membrane vesicles (OMVs) as a promising immunogen for improving pertussis vaccines. In this study, we evaluated the efficacy of our vaccine prototype in immunization s…
View article: Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron
Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron Open
In this study, we evaluated the efficacy of a heterologous three-dose vaccination schedule against the Omicron BA.1 SARS-CoV-2 variant infection using a mouse intranasal challenge model. The vaccination schedules tested in this study consi…
View article: Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron
Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron Open
In this study, we evaluated the efficacy of a heterologous three-dose vaccination schedule against the Omicron BA.1 SARS-CoV-2 variant infection using a mouse intranasal challenge model. The vaccination schedules tested in this study consi…
View article: Impact of maternal whole-cell or acellular pertussis primary immunization on neonatal immune response
Impact of maternal whole-cell or acellular pertussis primary immunization on neonatal immune response Open
With the introduction of pertussis immunization for pregnant women in many countries, there has been renewed interest in the impact of whole-cell pertussis vaccine (wP) versus acellular vaccine (aP) on disease control, particularly regardi…
View article: Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity Open
After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination sch…
View article: Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative
Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative Open
Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first …
View article: Immunological study of COVID-19 vaccine candidate based on recombinant spike trimer protein from different SARS-CoV-2 variants of concern
Immunological study of COVID-19 vaccine candidate based on recombinant spike trimer protein from different SARS-CoV-2 variants of concern Open
The emergency of new SARS-CoV-2 variants that feature increased immune escape marks an urgent demand for better vaccines that will provide broader immunogenicity. Here, we evaluated the immunogenic capacity of vaccine candidates based on t…
View article: Immunogenicity and reactogenicity of heterologous immunization against SARS CoV-2 using Sputnik V, ChAdOx1-S, BBIBP-CorV, Ad5-nCoV, and mRNA-1273
Immunogenicity and reactogenicity of heterologous immunization against SARS CoV-2 using Sputnik V, ChAdOx1-S, BBIBP-CorV, Ad5-nCoV, and mRNA-1273 Open
Heterologous vaccination against coronavirus disease 2019 (COVID-19) provides a rational strategy to rapidly increase vaccination coverage in many regions of the world. Although data regarding messenger RNA (mRNA) and ChAdOx1 vaccine combi…
View article: Pertussis Vaccine Candidate Based on Outer Membrane Vesicles Derived From Biofilm Culture
Pertussis Vaccine Candidate Based on Outer Membrane Vesicles Derived From Biofilm Culture Open
Outer membrane vesicles (OMV) derived from Bordetella pertussis— the etiologic agent of the resurgent disease called pertussis—are safe and effective in preventing bacterial colonization in the lungs of immunized mice. Vaccine formulations…
View article: Pool Strategy for Surveillance Testing of SARS-CoV-2
Pool Strategy for Surveillance Testing of SARS-CoV-2 Open
Due to the great morbidity and mortality in the risk groups of the pandemic COVID-19 caused by the emerging coronavirus SARS-CoV-2 and in the absence of effective therapeutic or preventive measures, quarantines, social distancing and the u…
View article: Active Surveillance of Asymptomatic, Presymptomatic, and Oligosymptomatic SARS-CoV-2-Infected Individuals in Communities Inhabiting Closed or Semi-closed Institutions
Active Surveillance of Asymptomatic, Presymptomatic, and Oligosymptomatic SARS-CoV-2-Infected Individuals in Communities Inhabiting Closed or Semi-closed Institutions Open
Background: The high COVID-19 dissemination rate demands active surveillance to identify asymptomatic, presymptomatic, and oligosymptomatic (APO) SARS-CoV-2-infected individuals. This is of special importance in communities inhabiting clos…
View article: Canonical and Non-canonical Inflammasome Activation by Outer Membrane Vesicles Derived From Bordetella pertussis
Canonical and Non-canonical Inflammasome Activation by Outer Membrane Vesicles Derived From Bordetella pertussis Open
Outer Membrane Vesicles (OMVs) derived from different Gram-negative bacteria have been proposed as an attractive vaccine platform because of their own immunogenic adjuvant properties. Pertussis or whooping cough is a highly contagious vacc…
View article: Highlights of the 12th International<i>Bordetella</i>Symposium
Highlights of the 12th International<i>Bordetella</i>Symposium Open
To commemorate the 100th anniversary of the Nobel prize being awarded to Jules Bordet, the discoverer of Bordetella pertussis, the 12th International Bordetella Symposium was held from 9 to 12 April 2019 at the Université Libre de Bruxelle…
View article: Use of a Neonatal-Mouse Model to Characterize Vaccines and Strategies for Overcoming the High Susceptibility and Severity of Pertussis in Early Life
Use of a Neonatal-Mouse Model to Characterize Vaccines and Strategies for Overcoming the High Susceptibility and Severity of Pertussis in Early Life Open
Newborns and unvaccinated infants, compared to other age groups, are more susceptible to pertussis infection, manifesting severe symptoms leading to a higher mortality. The recent increase in pertussis cases demands more effective strategi…
View article: Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development
Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development Open
Pertussis is a severe respiratory disease caused by infection with the bacterial pathogen Bordetella pertussis . The disease affects individuals of all ages but is particularly severe and sometimes fatal in unvaccinated young infants. Othe…
View article: Rare Detection of<i>Bordetella pertussis</i>Pertactin-Deficient Strains in Argentina
Rare Detection of<i>Bordetella pertussis</i>Pertactin-Deficient Strains in Argentina Open
Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Per…
View article: <i>Bordetella bronchiseptica</i> Glycosyltransferase Core Mutants Trigger Changes in Lipid A Structure
<i>Bordetella bronchiseptica</i> Glycosyltransferase Core Mutants Trigger Changes in Lipid A Structure Open
Bordetella bronchiseptica, known to infect animals and rarely humans, expresses a lipopolysaccharide that plays an essential role in host interactions, being critical for early clearance of the bacteria. On a B. bronchiseptica 9.73 isolate…