Daniela Kramer
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View article: NOD2-Induced IκBζ Mediates a Protective Host Response against Epicutaneous Staphylococcus aureus Infection
NOD2-Induced IκBζ Mediates a Protective Host Response against Epicutaneous Staphylococcus aureus Infection Open
IκBζ, an atypical and largely unknown member of the IκB family, is a transcriptional coactivator of selective immune functions. In this study, we investigated the role of keratinocyte-derived IκBζ upon infection with a multidrug-resistant …
View article: Regulation and Function of the Atypical IκBs—Bcl‐3, IκB <sub>NS</sub> , and IκBζ—in Lymphocytes and Autoimmunity
Regulation and Function of the Atypical IκBs—Bcl‐3, IκB <sub>NS</sub> , and IκBζ—in Lymphocytes and Autoimmunity Open
Signaling pathways involving NF‐κB transcription factors have essential roles in inflammation, immunity, cell proliferation, differentiation, and survival. Classical IκB proteins, such as IκBα and IκBβ, bind to NF‐κB via ankyrin repeats to…
View article: Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma
Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma Open
Background IκBζ, a rather unknown co-regulator of NF-κB, is mostly inducibly expressed and can either activate or repress a specific subset of NF-κB target genes. While its role as a transcriptional regulator of various cytokines and chemo…
View article: LBA34 ENGOT-ov48/EUDARIO: European trial on enhanced DNA repair inhibition in ovarian cancer
LBA34 ENGOT-ov48/EUDARIO: European trial on enhanced DNA repair inhibition in ovarian cancer Open
sponsorship: The ENGOT-ov48/EUDARIO trial was fully funded by the seventh framework programme (FP7) project of the European Union (Grant agreement no 602602). Specific translational research received additional funded by Margaretha Hehberg…
View article: Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques
Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques Open
Background Eczema and psoriasis are common diseases. Despite both showing active epidermal contribution to the inflammatory process, their molecular aetiology and pathological mechanisms are different. Objective Further molecular insight i…
View article: LL37/self-DNA complexes mediate monocyte reprogramming
LL37/self-DNA complexes mediate monocyte reprogramming Open
LL37 alone and in complex with self-DNA triggers inflammatory responses in myeloid cells and plays a crucial role in the development of systemic autoimmune diseases, like psoriasis and systemic lupus erythematosus. We demonstrated that LL3…
View article: naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation
naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation Open
Neutrophil extracellular traps (NETs) are a key antimicrobial feature of cellular innate immunity mediated by polymorphonuclear neutrophils (PMNs). NETs counteract microbes but are also linked to inflammation in atherosclerosis, arthritis,…
View article: The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt+ regulatory T-cell subsets
The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt+ regulatory T-cell subsets Open
Peripherally-induced regulatory T cells (pTregs) expressing the retinoic acid receptor-related orphan-receptor gamma t (RORγt) are indispensable for intestinal immune homeostasis. Nuclear factor kappa family members regulate the differenti…
View article: IL-17A-driven psoriasis is critically dependent on IL-36 signaling
IL-17A-driven psoriasis is critically dependent on IL-36 signaling Open
Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the population worldwide. Previously, high levels of IL-36 family cytokines were found in psoriatic skin lesions, thereby contributing to keratinocyte h…
View article: Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors Open
Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, PD-L1 expression on cancer ce…
View article: Expression of E8^E2 Is Required for Wart Formation by Mouse Papillomavirus 1 <i>In Vivo</i>
Expression of E8^E2 Is Required for Wart Formation by Mouse Papillomavirus 1 <i>In Vivo</i> Open
HPV encodes an E8^E2 protein which acts as repressors of viral gene expression and genome replication. In cultured normal keratinocytes, E8^E2 is essential for long-term episomal maintenance of HPV 31 (HPV31) genomes, but not for that of H…
View article: Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions
Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions Open
Rationale: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important regulators of inflammation. The exact impact of ROS/RNS on cutaneous delayed-type hypersensitivity reaction (DTHR) is controversial. The aim of our …
View article: The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis Open
Psoriasis is a frequent, inflammatory skin disease characterized by keratinocyte hyperproliferation and a disease-related infiltration of immune cells. Here, we identified a novel proinflammatory signaling pathway driven by cyclin-dependen…
View article: MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53 Open
SummaryThe MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that MDM2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryon…
View article: Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma
Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma Open
Diffuse large B-cell lymphoma (DLBCL) represents the most common adult lymphoma and can be divided into 2 major molecular subtypes: the germinal center B-cell-like and the aggressive activated B-cell-like (ABC) DLBCL. Previous studies sugg…
View article: Globotriaosylceramide-induced reduction of KCa1.1 channel activity and activation of the Notch1 signaling pathway in skin fibroblasts of male Fabry patients with pain
Globotriaosylceramide-induced reduction of KCa1.1 channel activity and activation of the Notch1 signaling pathway in skin fibroblasts of male Fabry patients with pain Open
Gb3 deposition in skin fibroblasts may impair KCa1.1 activity and activate the Notch1 signaling pathway. The resulting increase in pro-inflammatory mediator expression may contribute to cutaneous nociceptor sensitization as a potential mec…
View article: Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation
Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation Open
The transcriptional activator IκBζ is a key regulator of psoriasis, but which cells mediate its pathogenic effect remains unknown. Here we found that IκBζ expression in keratinocytes triggers not only skin lesions but also systemic inflamm…
View article: Temporal Dynamics of Reactive Oxygen and Nitrogen Species and NF-κB Activation During Acute and Chronic T Cell–Driven Inflammation
Temporal Dynamics of Reactive Oxygen and Nitrogen Species and NF-κB Activation During Acute and Chronic T Cell–Driven Inflammation Open
Noninvasive in vivo imaging is capable of assessing the temporal dynamics of ROS/RNS production and NF-κB activation during progression from acute to chronic DTHR and enables monitoring of anti-inflammatory treatment responses.
View article: EUDARIO/ENGOTov-48: A European multicenter randomised phase II trial on the combination of the HSP90 inhibitor ganetespib with carboplatin followed by maintenance treatment with niraparib (+/- ganetespib) compared to platinum-based combination-chemotherapy followed by niraparib in relapsed platinum-sensitive ovarian cancer patients.
EUDARIO/ENGOTov-48: A European multicenter randomised phase II trial on the combination of the HSP90 inhibitor ganetespib with carboplatin followed by maintenance treatment with niraparib (+/- ganetespib) compared to platinum-based combination-chemotherapy followed by niraparib in relapsed platinum-sensitive ovarian cancer patients. Open
TPS5605 Background: Carboplatin (C) mainly acts by forming interstrand crosslinks (ICL) within the DNA double helix, which can only be removed by the Fanconi Anemia (FA) pathway. HSP90 inhibitors destabilise a number of HSP90 client protei…
View article: Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner
Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner Open
The Ebola virus glycoprotein (EBOV-GP) forms GP-containing microvesicles, so-called virosomes, which are secreted from GP-expressing cells. However, determinants of GP-virosome release and their functionality are poorly understood. We char…
View article: IκBζ is a key transcriptional regulator of IL-36–driven psoriasis-related gene expression in keratinocytes
IκBζ is a key transcriptional regulator of IL-36–driven psoriasis-related gene expression in keratinocytes Open
Proinflammatory cytokine signaling in keratinocytes plays a crucial role in the pathogenesis of psoriasis, a skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes and infiltration of inflammatory ce…
View article: Correction: Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells
Correction: Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells Open
Since publication of this article, the authors reported that the online version is missing the links to most of the Supplementary data, specifically, Supplementary Figures S1-S9; Supplementary Table S1; all legends to Supplementary Materia…
View article: Skin Globotriaosylceramide 3 Load Is Increased in Men with Advanced Fabry Disease
Skin Globotriaosylceramide 3 Load Is Increased in Men with Advanced Fabry Disease Open
Immunofluorescence on minimally invasive skin punch biopsies may be useful as a tool for assessment and follow-up in FD patients.