Daniela M. Vogt Weisenhorn

PINK1 regulates cholesterol homeostasis via SCAP phosphorylation in human dopaminergic neurons Open

Karan Sharma, Claudia Cavarischia-Rega, Д. И. Иванюк, Christine Fröhlich, Jos F. Brouwers , et al. · 2025

Cholesterol is a key lipid enriched in neuronal membranes and essential for signaling and synaptic transmission. An imbalance in cholesterol levels may affect synaptic plasticity and contribute to neurodegeneration. Here, we identify in hu…

Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease Open

Natália Prudente de Mello, Michael Berger, Kim A. Lagerborg, Yingfei Yan, Jennifer Wettmarshausen , et al. · 2025

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies Open

Wolfgang Wurst, Maren Kirstin Schuhmacher, Christoph Gruber, Christopher M. Lang, Ricardo Ruijpers , et al. · 2024

Evolution guides biological systems to populate ecological niches, with viruses being one of the most successful examples of that principle. Viruses evolved over billions of years for the efficient transfer of nucleic acids. Although highl…

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation Open

Frida Lind‐Holm Mogensen, Carole Sousa, Corrado Ameli, Katja Badanjak, Sandro L. Pereira , et al. · 2024

Background Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role …

A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli Open

Sebastián A. Giusti, Natalia S. Pino, Camila Pannunzio, Mora B. Ogando, Natalia G. Armando , et al. · 2024

Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains unexplored, partly because of the lack of effective methods …

Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation Open

Sina Hembach, Sebastian Schmidt, Tanja Orschmann, Ingo Burtscher, Heiko Lickert , et al. · 2024

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation Open

Frida Lind‐Holm Mogensen, Carole Sousa, Corrado Ameli, Katja Badanjak, Arnaud Muller , et al. · 2024

Background Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role …

Molecular mechanisms underlying the onset of metabolic deficits in sporadic Parkinson’s disease Open

Sebastian Schmidt, Malte D. Luecken, Fabian J. Theis, Daniela M. Vogt Weisenhorn, Wolfgang Wurst · 2024

A reversible state of hypometabolism in a human cellular model of sporadic Parkinson’s disease Open

Sebastian Schmidt, Constantin Stautner, Duc Tung Vu, Alexander Heinz, Martin Regensburger , et al. · 2023

Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progress…

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein Open

Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian , et al. · 2022

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease Open

Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier , et al. · 2022

Source Data files for: Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease Open

Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier , et al. · 2022

Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomic…

Source Data files for: Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease Open

Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier , et al. · 2022

Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomic…

Source Data files for: Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease Open

Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier , et al. · 2022

Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomic…

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing Open

Egle Danileviciute, Ni Zeng, Christophe Capelle, Nicole Paczia, Mark A. Gillespie , et al. · 2022

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein Open

Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian , et al. · 2022

Parkinson′s disease (PD) pathology progresses throughout the nervous system affecting numerous neuronal structures. It has been postulated that the progression of the pathology is based on a prion-like disease mechanism partly due to the s…

Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons Open

Jessica Giehrl‐Schwab, Florian Giesert, Benedict Rauser, Chu Lan Lao, Sina Hembach , et al. · 2022

Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a knock-in mouse line carrying a dual dCas9 transactivator syst…

Chapter 5 – “Parkinson's disease – A role of non-enzymatic posttranslational modifications in disease onset and progression?” Open

Sebastian Schmidt, Daniela M. Vogt Weisenhorn, Wolfgang Wurst · 2022

Parkinson's disease (PD) is a still incurable neurodegenerative disorder with a highly complex etiology. While about 10% of cases are associated with single-gene mutations, the majority of PD is thought to originate from a combination of f…

Dose-dependent long-term effects of a single radiation event on behaviour and glial cells Open

Marie‐Claire Ung, Lillian Garrett, Claudia Dalke, Valentin Leitner, Daniel Dragosa , et al. · 2020

This is one of the first studies demonstrating such long-term and late-onset effects on brain and behaviour after a single radiation event in adulthood.

Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors Open

Christine Bus, Laimdota Zizmare, Marita Feldkaemper, Sven Geisler, Maria Zarani , et al. · 2020

β‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons Open

Jana Heppt, Marie‐Theres Wittmann, Iris Schäffner, Charlotte Billmann, Jingzhong Zhang , et al. · 2020

In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional integration of…

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease Open

Ibrahim Boussaad, Carolin D. Obermaier, Zoé Hanss, Dheeraj Reddy Bobbili, Silvia Bolognin , et al. · 2020

The genetic and pharmacological rescue of pathogenic U1-dependent exon skipping in c.192G>C PARK7 restores PD-associated cellular abnormalities in vitro.

Canonical Wnt-signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons Open

Jana Heppt, Marie‐Theres Wittmann, Jingzhong Zhang, Daniela M. Vogt Weisenhorn, Nilima Prakash , et al. · 2020

In adult hippocampal neurogenesis neural stem/progenitor cells generate new dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional inte…

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis Open

Egle Danileviciute, Ni Zeng, Christophe Capelle, Nicole Paczia, Mark A. Gillespie , et al. · 2019

Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme into the tricarboxylic acid (TCA) cycle. Here we show that PARK7/DJ-1, a key familial Parkinson’s disease (PD) gene, is a pacemaker controlling PDH activity in CD4 regulatory T cells (T…

PINK1 Regulates Dopamine and Lipids at Mitochondria to Maintain Synapses and Neuronal Function Open

Christine Bus, Sven Geisler, Marita Feldkaemper, Hector Flores‐Romero, Anna Schaedler , et al. · 2019

Mitochondrial dysfunction contributes to the pathogenesis of Parkinson’s disease but it is not clear why inherent mitochondrial defects lead specifically to the death of dopaminergic neurons of the mid brain. PINK1 is mitochondrial kinase …

The Parkinson’s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 Open

Natalja Funk, Marita Munz, Thomas Ott, Kathrin Brockmann, Andrea Wenninger-Weinzierl , et al. · 2019

Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1 Open

Axel Weber, Sigrid C. Schwarz, Jörg Tost, Dietrich Trümbach, Pia Winter , et al. · 2018

The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse Open

Florian Giesert, Lisa Glasl, Annemarie Zimprich, Luise Ernst, Giovanni Piccoli , et al. · 2017

Analysis of locomotor behavior in the German Mouse Clinic Open

Annemarie Zimprich, Manuela A. Östereicher, Lore Becker, Petra Dirscherl, Luise Ernst , et al. · 2017

Diversity matters – heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease Open

Daniela M. Vogt Weisenhorn, Florian Giesert, Wolfgang Wurst · 2016

Dopaminergic neurons in the ventral mesencephalon (the ventral mesencephalic dopaminergic complex) are known for their role in a multitude of behaviors, including cognition, reward, addiction and voluntary movement. Dysfunctions of these n…

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